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Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Andrew Whitfield I am doubtful if the Fisetin powder actually dissolved in buttermilk, as opposed to going into suspension. The distinction makes a big difference in whether it was present in good…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@JGC
- Retired Professor of Physics
- JGC
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Andrew Whitfield Did I
- Retired Professor of Physics
- JGC
- 4 yrs ago
- Senolytics Discussion
- Reported - view
CD38, NAD+ Deficiency, and Senescent Cells

There is a very interesting paper by Judy Campisi and the Buck Institute gang published in the journal Nature Metabolism. The authors tie the enzyme CD38 to the destruction of NAD+,…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 3replies
- 180
- 3
- General Discussion
Re: Fisetin to Clear Senescent Cells
@Endless Last week my wife and I did a 3-day session with 10 caps/day of LE's Bio Fisetin, which should be the equivalent of about 2 grams of Fisetin powder.…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Iðunn I don't think LifeExtension is just guessing based or rodent studies. As I recall the account I read somewhere, they used the same bio-enhancement coating trick that had been used on curcumin,…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
New Senolytics Targeting ß-Galactosidase

The standard way of identifying senescent cells in vitro is to stain a tissue biopsy with a dye that turns the enzyme ß-galactosidase a dark blue, and then counting the population of blue cells as…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 58
- 2
- General Discussion
Re: Fisetin to Clear Senescent Cells
@Dan Nave I ran down the published paper by researchers in India on which the Life Extension technique for increased bio-availability of flavenoids (curcumin, fisetin, quercetin, ...…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@LCM Good question without a good answer. The published research on Fisetin senolytics is on mice, with the Fisetin added to their mouse-chow, and on human cells,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: DNA methylation test
A Few Answers to my DNAm Age Questions I've read further and have found tentative answers to some of my questions listed above. (1) About 2/3 of the CpG sites used by Horvath have methylation that…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 4
- Assessing Biological Age
- Reported - view
Re: Bio-Fisetin, a x25 Boost in Bioavailability?
@David H That sounds great, but it has the ring of emptiness. There is already much research on the senolytic effects of fisetin on aging mice and on human tissue cultures that demonstrates its high…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Bio-Fisetin, a x25 Boost in Bioavailability?
@David H I think to get the equivalent of 3 g, you would take 15 caps.
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Bio-Fisetin, a x25 Boost in Bioavailability?
@David H You are correct, David. LE's Bio-Fisetin page references their Curcumin Elite page (which uses the same bio-boost trick), which in turn gives journal references.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Bio-Fisetin, a x25 Boost in Bioavailability?
@T F Yes, BF did say that. However, there seems to be a threshold effect in the mouse study. I seriously doubt if you can just take 10% of the dose and clear 10% of the senescent cells that you…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Bio-Fisetin, a x25 Boost in Bioavailability?

One of the big problems with senolytic flavenoids like Fisetin and Quercetin is that they have a very low solubility in water and poor survival in the digestive tract,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 13replies
- 1099
- 4
- Self-Experimentation
Re: Senolytics
@JOHN ' I think that it is highly desirable to do something to replace the cleared cells if you want to get the maximum effect of senolytics. However, as yet I have not done anything in that…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Senolytics
@JGC said: I wonder what the water solubility of SSK1 is. I found HERE that the solubility in warm water of Gemcitabine, the principal molecular component of SSK1, is 25 mg/ml. That isn't bad.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Senolytics
@JOHN said: In your opinion do you think Unity Bio has a shot with their next trial on vision? I wouldn't put any money on it. Essentially, the flawed approach of Unity Bio involves repurposing a…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Senolytics
@Paul Beauchemin said: attacking senescent cells is evolving as the #1 treatment for aging In my view, clearing senescent cells is the first step (but by no means the last) in treating aging.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 4
- Self-Experimentation
- Reported - view
Re: Man stopped aging !!!
@Peter North These people had a head injury that destroyed their pituitary gland and stopped their normal growth process. I doubt if you would like that,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- General Discussion
- Reported - view
Re: Senolytics
@Dan Nave On the other hand, the Chinese paper gives explicit instructions for how to synthesize SSK1, and it's simple enough that most organic chemists in well-equipped labs could do the job.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Dr. Sinclair claims he reversed his Horvath clock by 29 years!
@Fred Cloud It's possible that you might have had a DNAm age in excess of your calendar age, but considering that you are on this list and have done various interventions,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- General Discussion
- Reported - view
Re: Senolytics
@Dan Nave I don't think SSK1 could be made available here in the USA without having first a trial on humans. It would be very hard to get the FDA to approve such a trial on a drug that treats aging…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Senolytics
@Joe smith You said "big-time researchers like Judith Campisi and Dimitry Bulavin clearly state and demonstrate through their research that senolitics don’t extend the lifespan.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 4
- Self-Experimentation
- Reported - view
Re: Dr. Sinclair claims he reversed his Horvath clock by 29 years!
@Fred Cloud That is dismaying news, Fred. Steve Perry has made such a big deal about how GDF11 is one of the few interventions that lowers the Horvath DNAm age.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- General Discussion
- Reported - view

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