Dihomo-15d-PGJ2: A New Test for Senolytic Effectiveness

    The Campisi Group at the Buck Institute has published a paper in the journal Cell Metabolism  showing that the presence of the molecule dihomo-15d-PGJ2  in blood or urine samples definitively indicates that senescent cells have been destroyed.  In other words, the presence of dihomo-15d-PGJ2 is a definite indication that a senolytic drug treatment is actually working.

    In principle, this would be very valuable for those of us doing senolytic self-experiments with D+Q and/or Fisetin.  However, it raises a practical question:  How does one arrange for a quantitative test of blood or urine for the presence and quantity of dihomo-15d-PGJ2?  High Precision Liquid Chromatography + Mass Spectrometry to look for a molecule with the right molecular weight (344.5 g/mol)?  BioChip detection in a pixel-well containing an antibody that specifically grabs dihomo-15d-PGJ2?

    Does anyone have any experie4nce or expertise in arranging for such testing?

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  • Is there any current test strategies for measuring the progress of one's senolytic efforts?   For me, there's no way to now do a before test...  So it needs to be an absolute value indication, like a CRP test number...  ;)

    Or direct me to the thread, search did not find much.  Tnx to all.

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