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Re: Gingernone A is a Better-than-D+Q Senolytic I should add that in Figure 1 of the paper describing the identification of Gingerenone A (note spelling, which was incorrect above) as a senolytic, the authors tried two concentration levels,…
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Any results from D & Q course? @Fred Cloud I have on occasion spaced senolytic sessions 3 months apart, when I had some indication of persistent muscle pain, etc. However, the unresolved question is how fast the body burden of…
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- Self-Experimentation
- Reported - view
Re: Any results from D & Q course? I am 87 years old. I have been doing some form of 3-day D+Q senolytic sessions about every 6 months for the past several years. Before starting, I had several colonoscopies in which 5-10…
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Gingernone A is a Better-than-D+Q Senolytic @John Hemming I disagree. It's like trying to repurpose the garbage in your house instead of getting rid of it. Cells go senescent because they are damaged in some way and can't perform their…
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- 3
- Self-Experimentation
- Reported - view
Gingernone A is a Better-than-D+Q Senolytic
A post in Lifespan.io discusses a recent paper published last month in PLoS One in which the polyphenol Gingernone A, a strong component of Ginger Root Extract,…
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- 8replies
- 385
- 3
- Self-Experimentation
Re: Anyone actually experience marked increased energy from NMN? @John Hemming In that context, you might list the suppliers of Melatonin you know of that DO provide 3rd party lab tests of their product.
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN? Have a look at the discussion of Melatonin by CNN at this LINK. It says that because of the lack of regulation, over-the-counter Melatonin pills may contain up to 478% of the dosage stated on the…
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- Self-Experimentation
- Reported - view
Re: Variability Among Horvath-type DNA Methylation Age Tests @isaac JOSEPH I posted the diagram, which shows your chart of general average test results vs chorological age, to which my individual score and age have been added.…
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- Assessing Biological Age
- Reported - view
Re: Anyone actually experience marked increased energy from NMN? @John Hemming My conclusion (which is really a conjecture) was based on my attempt to understand the mechanism behind the sleep-inducing properties on Melatonin.…
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN? @John Hemming Interesting. I note the NIH says that the biovailability of Melatonin is about 15%, and it's solubility in water is about 0.1 mg/ml. Therefore,…
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN? @Paul Beauchemin Are there any published studies indicating that taking Melatonin at the dose level of 120 mg or more is a good idea? I thought that it was a hormone that was most effective at the…
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now I decided to pass on Kiprov's procedure. The deciding factor for me was that treated subjects have reported some benefits that disappear in a few months,…
- JGC
- Retired Professor of Physics
- JGC
- 3 yrs ago
- 2
- General Discussion
- Reported - view
Re: Does anyone know what the status of RapaPro Is? A couple of years ago, I had already ordered some RapaPro from the AntiAging Store when the controversy about its strength arose. I contacted them, threatening to cancel my order.…
- JGC
- Retired Professor of Physics
- JGC
- 3 yrs ago
- 2
- Rapamycin Discussion
- Reported - view
Re: Making sirolimus cream---Tried to grind a 2mg rapamune pill with a grinder and then dissolve in DMSO to put in cream. I purchased 10 grams of 99% pure Rapamycin powder for $200 from rainbow@multin.cn , who is a rep for Zhejiang Multinpharma Ltd. That's easier than trying to grind up pills.…
- JGC
- Retired Professor of Physics
- JGC
- 3 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Apigenin: An Alternative Way of Boosting NAD+ @Fred Cloud NMN and Apigenin are certainly not mutually exclusive. In fact, taking both is probably a good idea. I just wish there was a good way of monitoring the NAD+ level,…
- JGC
- Retired Professor of Physics
- JGC
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Apigenin: An Alternative Way of Boosting NAD+ @Staffan Olsson I think piperine enhancement should work for Apigenin, since it suppresses digestive enzymes that break down flavonoids. I found a paper that makes this statement about its…
- JGC
- Retired Professor of Physics
- JGC
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Apigenin: An Alternative Way of Boosting NAD+ @Staffan Olsson All flavonoids have bioavailability problems because they are not very soluble in water and are broken down by digestion before they can be absorbed.…
- JGC
- Retired Professor of Physics
- JGC
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Apigenin: An Alternative Way of Boosting NAD+ @Fred Cloud Dr. Verdin did mention senolytics as a suppressor of CD38, but it isn't clear if accumulation of senescent cells is the only reason that CD38 increases with age.…
- JGC
- Retired Professor of Physics
- JGC
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Apigenin: An Alternative Way of Boosting NAD+ @Kaptain Asia I take 50 mg/day, i.e, one capsule of Apigenin. However, that's just the Swanson "serving size". There's no data that I know of on how much Apigenin it takes to effectively suppress…
- JGC
- Retired Professor of Physics
- JGC
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Apigenin: An Alternative Way of Boosting NAD+ Yes, Verdin made the point that senescent cells produce CD38 as a part of SASP. One other point: apparently Resveratrol 2 enhances the anti-CD38 effects of Apigenin.
- JGC
- Retired Professor of Physics
- JGC
- 3 yrs ago
- Self-Experimentation
- Reported - view
Apigenin: An Alternative Way of Boosting NAD+
At the recent Ending Age-Related Diseases 2021 online conference, Dr. Eric Verdin of the Buck Institute gave a talk in which he described the mechanism behind the well-known drop in NAD+ with age,…
- JGC
- Retired Professor of Physics
- JGC
- 3 yrs ago
- 22replies
- 667
- 5
- Self-Experimentation
Re: IVERMECTIN/PROPHYLACTIC DOCTOR FLORIDA @Jimmy2 Here's a .pdf of the article:
Attachment
- JGC
- Retired Professor of Physics
- JGC
- 3 yrs ago
- General Discussion
- Reported - view
Re: IVERMECTIN/PROPHYLACTIC DOCTOR FLORIDA Read the WP Article, which contains a link to the Brazilian study.
- JGC
- Retired Professor of Physics
- JGC
- 3 yrs ago
- General Discussion
- Reported - view
Re: IVERMECTIN/PROPHYLACTIC DOCTOR FLORIDA @Jimmy2 This LINK is what the Washington Post has to say about the misguided use of Ivermectin. The best work, done in Brazil, indicates that it works about as well as a placeo.
- JGC
- Retired Professor of Physics
- JGC
- 3 yrs ago
- General Discussion
- Reported - view
Re: IVERMECTIN/PROPHYLACTIC DOCTOR FLORIDA Which do you have: worms or head lice?
- JGC
- Retired Professor of Physics
- JGC
- 3 yrs ago
- 1
- General Discussion
- Reported - view

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JGC

Retired Professor of Physics

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Joined: Mon Aug 13 01:22:01 UTC 2018

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http://faculty.washington.edu/jcramer/