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Re: Fisetin to Clear Senescent Cells
@Jimmy2 Addressing the issue of whether Miller is using a large enough senolytic dose, I did the following calculation: When I do a 3-day senolytic session (like yesterday through tomorrow), I take 2,…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 4
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Jimmy2 OK, I went to the Interventions Testing Program (ITP) web site looking for more information on just how they tested Fisetin. They list a large number of ITP publications,…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Sea squirts, mussels and longevity
@Fred Cloud Yes, and Prodrome's high plasmologen supplement costs $199/month. Of course, for that they give you 900 mg/capsule. The question is, for good brain health, do you need that much?
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Jimmy2 I just watched Miller's presentation. His mention of Fisetin was very brief and dismissive, and he did not say specifically how it was given to his test mice.…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Sea squirts, mussels and longevity
It would appear that daily doses of supplements containing plasmalogens are beneficial to brain health and anti-aging. The imported Japanese sea scallop products seem to cost around $90 for a…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Gingernone A is a Better-than-D+Q Senolytic
I should add that in Figure 1 of the paper describing the identification of Gingerenone A (note spelling, which was incorrect above) as a senolytic, the authors tried two concentration levels,…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Any results from D & Q course?
@Fred Cloud I have on occasion spaced senolytic sessions 3 months apart, when I had some indication of persistent muscle pain, etc. However, the unresolved question is how fast the body burden of…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Any results from D & Q course?
I am 87 years old. I have been doing some form of 3-day D+Q senolytic sessions about every 6 months for the past several years. Before starting, I had several colonoscopies in which 5-10…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Gingernone A is a Better-than-D+Q Senolytic
@John Hemming I disagree. It's like trying to repurpose the garbage in your house instead of getting rid of it. Cells go senescent because they are damaged in some way and can't perform their…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 3
- Self-Experimentation
- Reported - view
Gingernone A is a Better-than-D+Q Senolytic

A post in Lifespan.io discusses a recent paper published last month in PLoS One in which the polyphenol Gingernone A, a strong component of Ginger Root Extract,…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 8replies
- 426
- 3
- Self-Experimentation
Re: Anyone actually experience marked increased energy from NMN?
@John Hemming In that context, you might list the suppliers of Melatonin you know of that DO provide 3rd party lab tests of their product.
- Retired Professor of Physics
- JGC
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
Have a look at the discussion of Melatonin by CNN at this LINK. It says that because of the lack of regulation, over-the-counter Melatonin pills may contain up to 478% of the dosage stated on the…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Variability Among Horvath-type DNA Methylation Age Tests
@isaac JOSEPH I posted the diagram, which shows your chart of general average test results vs chorological age, to which my individual score and age have been added.…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- Assessing Biological Age
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@John Hemming My conclusion (which is really a conjecture) was based on my attempt to understand the mechanism behind the sleep-inducing properties on Melatonin.…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@John Hemming Interesting. I note the NIH says that the biovailability of Melatonin is about 15%, and it's solubility in water is about 0.1 mg/ml. Therefore,…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@Paul Beauchemin Are there any published studies indicating that taking Melatonin at the dose level of 120 mg or more is a good idea? I thought that it was a hormone that was most effective at the ~1…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now
I decided to pass on Kiprov's procedure. The deciding factor for me was that treated subjects have reported some benefits that disappear in a few months,…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 2
- General Discussion
- Reported - view
Re: Does anyone know what the status of RapaPro Is?
A couple of years ago, I had already ordered some RapaPro from the AntiAging Store when the controversy about its strength arose. I contacted them, threatening to cancel my order.…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 2
- Rapamycin Discussion
- Reported - view
Re: Making sirolimus cream---Tried to grind a 2mg rapamune pill with a grinder and then dissolve in DMSO to put in cream.
I purchased 10 grams of 99% pure Rapamycin powder for $200 from rainbow@multin.cn , who is a rep for Zhejiang Multinpharma Ltd. That's easier than trying to grind up pills.…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Apigenin: An Alternative Way of Boosting NAD+
@Fred Cloud NMN and Apigenin are certainly not mutually exclusive. In fact, taking both is probably a good idea. I just wish there was a good way of monitoring the NAD+ level,…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Apigenin: An Alternative Way of Boosting NAD+
@Staffan Olsson I think piperine enhancement should work for Apigenin, since it suppresses digestive enzymes that break down flavonoids. I found a paper that makes this statement about its…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Apigenin: An Alternative Way of Boosting NAD+
@Staffan Olsson All flavonoids have bioavailability problems because they are not very soluble in water and are broken down by digestion before they can be absorbed.…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Apigenin: An Alternative Way of Boosting NAD+
@Fred Cloud Dr. Verdin did mention senolytics as a suppressor of CD38, but it isn't clear if accumulation of senescent cells is the only reason that CD38 increases with age.…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Apigenin: An Alternative Way of Boosting NAD+
@Kaptain Asia I take 50 mg/day, i.e, one capsule of Apigenin. However, that's just the Swanson "serving size". There's no data that I know of on how much Apigenin it takes to effectively suppress…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Apigenin: An Alternative Way of Boosting NAD+
Yes, Verdin made the point that senescent cells produce CD38 as a part of SASP. One other point: apparently Resveratrol 2 enhances the anti-CD38 effects of Apigenin.
- Retired Professor of Physics
- JGC
- 4 yrs ago
- Self-Experimentation
- Reported - view

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