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Re: Senolytic Effects of FOXO4-DRI
What Happened to Senolytics with FOXO4-DRI? This topic discussion was started several years ago, when the big news in senolytics was that a new treatment, FOXO4-DRI,…
- Retired Professor of Physics
- JGC
- 3 yrs ago
- 4
- Senolytics Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@Fred Cloud Actually, it's $0.06 per mg, because the caps only contain 5 mg of spermidine hydrochloride, with a "serving size" of two caps. I really object to the serving-size games these supplement…
- Retired Professor of Physics
- JGC
- 3 yrs ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@Fred Cloud Good suggestion! The price comes to $0.03/mg of spermidine trihydrochloride. This was not available when I made the table that is on this thread. Anyhow, I just ordered two bottles.
- Retired Professor of Physics
- JGC
- 3 yrs ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@Jay Orman You may be right, and it's a question that can only be really answered by a chemical analysis. My model is that in cold pressing, whatever liquid is in the wheat germ, mostly oil,…
- Retired Professor of Physics
- JGC
- 3 yrs ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@Jay Orman Oops! I just looked at the bottle label, and Swanson's Wheat Germ Oil contains 1,130 mg of wheat germ oil (not 1,310 mg). That calculates to 2.83 mg of Spermidine per capsule.…
- Retired Professor of Physics
- JGC
- 3 yrs ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@Jay Orman OK, here's where my number of about 3 mg /cap came from. In June 2021 I corresponded by email with one Mary L. , who is a Product Specialist for Swanson.…
- Retired Professor of Physics
- JGC
- 3 yrs ago
- General Discussion
- Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@John Hemming Yes, CRP tests are cheap. At the moment, Life Extension does their CRP tests for $31.50. I have tested and noticed some decrease in the CRP level following a senolytic session.…
- Retired Professor of Physics
- JGC
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@Chris M There are methods of measuring senescent cells, but no really cheap and satisfactory way: (1) The senescent cells in a tissue sample can be stained to indicate the presence of…
- Retired Professor of Physics
- JGC
- 3 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@UB I was taking RapaPro once a week obtained from The Antiaging Store until I ran out and encountered supply problems and Chinese scam artists. Do you know of a reliable supplier?
- Retired Professor of Physics
- JGC
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Dasatinib update
@Jared How do you know that you aren't suppressing the senolytic effect? I take the flu-like symptoms of D+Q as an indication that senescent cells are being disassembled and the debris in the…
- Retired Professor of Physics
- JGC
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@UB You said: "once a month?...roughly the amount of time it takes for a senescent cell to start secreting SASP, ..." Where does that time estimate come from?…
- Retired Professor of Physics
- JGC
- 3 yrs ago
- 4
- Self-Experimentation
- Reported - view
Re: Yeast-Displayed GDF11 and Oral Delivery
@Fred Cloud NOTE: The permissions on my link to the paper above were set wrong, but I think that is now fixed. Yes, dosing is a problem, but all that means is that one has to be careful not to take…
- Retired Professor of Physics
- JGC
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Yeast-Displayed GDF11 and Oral Delivery

Through the work of Steve Perry, it appears that taking growth differentiation factor 11 (GDF11) provides definite health benefits and some evidence of rejuvenation.…
- Retired Professor of Physics
- JGC
- 3 yrs ago
- 4replies
- 138
- 1
- Self-Experimentation
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@Staffan Olsson Fortunately, my prostate is normal size and has not yet been a problem.
- Retired Professor of Physics
- JGC
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@UB As I understand it, Dasatinib and the flavonoids induce senescent cells to finish the job started by halting cell division by going into apoptosis.…
- Retired Professor of Physics
- JGC
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@chuck stanley On the basis of your references, piperine probably does boost the bioavailability of Dasatinib, which like flavonoids does have low solubility in water.…
- Retired Professor of Physics
- JGC
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@Staffan Olsson I'm bit vague about the difference between piperine and piperlongumine. I took 10 mg of the former and 80 mg of the latter in my three senolytic sessions.…
- Retired Professor of Physics
- JGC
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@Fred Cloud You may be right, Fred, but until we can do real senolytic-effectiveness tests (maybe by using Judy Campisi's killed-senescent-cell detection technique) there is no way of really knowing.…
- Retired Professor of Physics
- JGC
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@Michael See my reply to Karl above. Yes, I think the flu-like symptoms are the body's response to having the debris resulting from cell disassembly (apoptosis) dumped into the bloodstream.…
- Retired Professor of Physics
- JGC
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@Karl All of the individual supplements (except the anti-cancer drug Dasatinib) are considered safe and are not known to produce intestinal cramps or mild fever).…
- Retired Professor of Physics
- JGC
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
I think piperine only effects flavonoid input.
- Retired Professor of Physics
- JGC
- 3 yrs ago
- Self-Experimentation
- Reported - view
D+Q+F+P+L+G+GLA: A New Senolytic Cocktail

For my May 15-18 senolytic session I tried something new. In a recent Foresight Institute talk available on YouTube, James Kirkland identified the flavonoid Luteolin as a senolytic.…
- Retired Professor of Physics
- JGC
- updated 3 yrs ago
- 40replies
- 901
- 4
- Self-Experimentation
Re: Fisetin to Clear Senescent Cells
@Jimmy2 Addressing the issue of whether Miller is using a large enough senolytic dose, I did the following calculation: When I do a 3-day senolytic session (like yesterday through tomorrow),…
- Retired Professor of Physics
- JGC
- 3 yrs ago
- 4
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Jimmy2 OK, I went to the Interventions Testing Program (ITP) web site looking for more information on just how they tested Fisetin. They list a large number of ITP publications,…
- Retired Professor of Physics
- JGC
- 3 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Sea squirts, mussels and longevity
@Fred Cloud Yes, and Prodrome's high plasmologen supplement costs $199/month. Of course, for that they give you 900 mg/capsule. The question is, for good brain health, do you need that much?
- Retired Professor of Physics
- JGC
- 3 yrs ago
- 2
- Self-Experimentation
- Reported - view

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