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Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@Jay Orman Oops! I just looked at the bottle label, and Swanson's Wheat Germ Oil contains 1,130 mg of wheat germ oil (not 1,310 mg). That calculates to 2.83 mg of Spermidine per capsule.…
JGC
Retired Professor of Physics
JGC
1 yr ago
General Discussion
Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@Jay Orman OK, here's where my number of about 3 mg /cap came from. In June 2021 I corresponded by email with one Mary L. , who is a Product Specialist for Swanson.…
JGC
Retired Professor of Physics
JGC
1 yr ago
General Discussion
Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@John Hemming Yes, CRP tests are cheap. At the moment, Life Extension does their CRP tests for $31.50. I have tested and noticed some decrease in the CRP level following a senolytic session.…
JGC
Retired Professor of Physics
JGC
1 yr ago
Self-Experimentation
Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@Chris M There are methods of measuring senescent cells, but no really cheap and satisfactory way: (1) The senescent cells in a tissue sample can be stained to indicate the presence of…
JGC
Retired Professor of Physics
JGC
1 yr ago
1
Self-Experimentation
Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@UB I was taking RapaPro once a week obtained from The Antiaging Store until I ran out and encountered supply problems and Chinese scam artists. Do you know of a reliable supplier?
JGC
Retired Professor of Physics
JGC
1 yr ago
Self-Experimentation
Reported - view
Re: Dasatinib update
@Jared How do you know that you aren't suppressing the senolytic effect? I take the flu-like symptoms of D+Q as an indication that senescent cells are being disassembled and the debris in the…
JGC
Retired Professor of Physics
JGC
1 yr ago
1
Self-Experimentation
Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@UB You said: "once a month?...roughly the amount of time it takes for a senescent cell to start secreting SASP, ..." Where does that time estimate come from?…
JGC
Retired Professor of Physics
JGC
1 yr ago
4
Self-Experimentation
Reported - view
Re: Yeast-Displayed GDF11 and Oral Delivery
@Fred Cloud NOTE: The permissions on my link to the paper above were set wrong, but I think that is now fixed. Yes, dosing is a problem, but all that means is that one has to be careful not to take…
JGC
Retired Professor of Physics
JGC
1 yr ago
1
Self-Experimentation
Reported - view
Yeast-Displayed GDF11 and Oral Delivery
Through the work of Steve Perry, it appears that taking growth differentiation factor 11 (GDF11) provides definite health benefits and some evidence of rejuvenation.…
JGC
Retired Professor of Physics
JGC
1 yr ago
4
replies
127
1
Self-Experimentation
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@Staffan Olsson Fortunately, my prostate is normal size and has not yet been a problem.
JGC
Retired Professor of Physics
JGC
1 yr ago
Self-Experimentation
Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@UB As I understand it, Dasatinib and the flavonoids induce senescent cells to finish the job started by halting cell division by going into apoptosis.…
JGC
Retired Professor of Physics
JGC
1 yr ago
1
Self-Experimentation
Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@chuck stanley On the basis of your references, piperine probably does boost the bioavailability of Dasatinib, which like flavonoids does have low solubility in water.…
JGC
Retired Professor of Physics
JGC
1 yr ago
1
Self-Experimentation
Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@Staffan Olsson I'm bit vague about the difference between piperine and piperlongumine. I took 10 mg of the former and 80 mg of the latter in my three senolytic sessions.…
JGC
Retired Professor of Physics
JGC
1 yr ago
Self-Experimentation
Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@Fred Cloud You may be right, Fred, but until we can do real senolytic-effectiveness tests (maybe by using Judy Campisi's killed-senescent-cell detection technique) there is no way of really knowing.…
JGC
Retired Professor of Physics
JGC
1 yr ago
Self-Experimentation
Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@Michael See my reply to Karl above. Yes, I think the flu-like symptoms are the body's response to having the debris resulting from cell disassembly (apoptosis) dumped into the bloodstream.…
JGC
Retired Professor of Physics
JGC
1 yr ago
Self-Experimentation
Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
@Karl All of the individual supplements (except the anti-cancer drug Dasatinib) are considered safe and are not known to produce intestinal cramps or mild fever).…
JGC
Retired Professor of Physics
JGC
1 yr ago
Self-Experimentation
Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
I think piperine only effects flavonoid input.
JGC
Retired Professor of Physics
JGC
1 yr ago
Self-Experimentation
Reported - view
D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
For my May 15-18 senolytic session I tried something new. In a recent Foresight Institute talk available on YouTube, James Kirkland identified the flavonoid Luteolin as a senolytic.…
JGC
Retired Professor of Physics
JGC
updated
1 yr ago
33
replies
709
4
Self-Experimentation
Re: Fisetin to Clear Senescent Cells
@Jimmy2 Addressing the issue of whether Miller is using a large enough senolytic dose, I did the following calculation: When I do a 3-day senolytic session (like yesterday through tomorrow),…
JGC
Retired Professor of Physics
JGC
1 yr ago
4
Self-Experimentation
Reported - view
Re: Fisetin to Clear Senescent Cells
@Jimmy2 OK, I went to the Interventions Testing Program (ITP) web site looking for more information on just how they tested Fisetin. They list a large number of ITP publications,…
JGC
Retired Professor of Physics
JGC
1 yr ago
2
Self-Experimentation
Reported - view
Re: Sea squirts, mussels and longevity
@Fred Cloud Yes, and Prodrome's high plasmologen supplement costs $199/month. Of course, for that they give you 900 mg/capsule. The question is, for good brain health, do you need that much?
JGC
Retired Professor of Physics
JGC
1 yr ago
2
Self-Experimentation
Reported - view
Re: Fisetin to Clear Senescent Cells
@Jimmy2 I just watched Miller's presentation. His mention of Fisetin was very brief and dismissive, and he did not say specifically how it was given to his test mice.…
JGC
Retired Professor of Physics
JGC
1 yr ago
3
Self-Experimentation
Reported - view
Re: Sea squirts, mussels and longevity
It would appear that daily doses of supplements containing plasmalogens are beneficial to brain health and anti-aging. The imported Japanese sea scallop products seem to cost around $90 for a…
JGC
Retired Professor of Physics
JGC
1 yr ago
Self-Experimentation
Reported - view
Re: Gingernone A is a Better-than-D+Q Senolytic
I should add that in Figure 1 of the paper describing the identification of Gingerenone A (note spelling, which was incorrect above) as a senolytic, the authors tried two concentration levels,…
JGC
Retired Professor of Physics
JGC
2 yrs ago
2
Self-Experimentation
Reported - view
Re: Any results from D & Q course?
@Fred Cloud I have on occasion spaced senolytic sessions 3 months apart, when I had some indication of persistent muscle pain, etc. However, the unresolved question is how fast the body burden of…
JGC
Retired Professor of Physics
JGC
2 yrs ago
Self-Experimentation
Reported - view
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JGC
Retired Professor of Physics
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