The Conboy Plasma-Dilution Treatment is Available Now
Recently, watching a video interview of Irina Conboy, I became aware that Conboy plasma-dilution for humans is available in San Francisco and Miami from the medical practice of Dobri Kiprov, MD, who works with and has published with Profs. Irina and Michael Conboy of UC Berkeley. Here are links to videos and writeups about Dr. Kiprov's work on plasma dilution:
https://youtu.be/5gGFJtKIUN0
https://neo.life/2021/06/perspective-therapeutic-plasma-exchange-the-future-of-aging/
https://www.TPEplus.com
I contacted Dr. Kiprov and had a Zoom call with him this morning. Here's what I learned:
- Kiprov's plasma-dilution protocol is slightly different from that described in the Conboy papers. He adds some proprietary ingredients to the saline + albumin to suppress negative immune reactions. I suspect that said reactions are caused by a stabilizer component that is in the albumin.
- Treatment for one person involving two sessions of plasma dilution spaced 2 days apart costs $6,000. There is a discount if a couple both have treatments at the same time.
- Several patients have had Horvath-type DNAm bio-age tests before and after treatment. The apparent epigenetic reset from the treatment is about 3-4 years. Kiprov does not think the epigenetic reprogramming is "permanent".
- The effects of the plasma dilution sessions are cumulative, and Kiprov recommends that they be done monthly for about 6 months, with semi-yearly or yearly treatments after that.
- The observations of recipients are that there are immediate benefits from a plasma dilution session, but they are observed to diminish in a few weeks. This motivates the repeated sessions.
- There are plans to set up more centers to perform plasma-dilution treatments at other population centers around the USA. No decisions yet about where.
I am considering arranging one set of plasma-dilution sessions for my wife and me next December (for ~$10k), but I don't think we can afford a full 6-month series of them (~$60k). Also, I am disappointed to learn that the apparent epigenetic reset of the Conboy treatment is only a few years. According to the paper published with Steve Horvath, Harold Katcher's E-5 treatment on rats produced an epigenetic reset by about a factor of 2.
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I and a friend are part of the Conboy/Kiprov - Alzheimer/Fraility study. We have had six treatments each. We each had a methylation age reduction. Each of our treatments was 2.5l replacement with saline/albumin. We both felt better for a while.
My significant improvements are known "side effects", lower blood pressure, liver regeneration. While I did achieve my lowest methylation age reduction of all experimental treatments tried, the Conboys and Kiprov discount this measurement.
I am considering additional treatments, based on measurements and am adding GrimAge measurements to the mix.
In my discussion with the Conboy's, they confirmed that blood donation would be a "cheap and dirty" effective approach. I am supporting a nanotechnology approach to removing "bad stuff" that may come to clinical trial in 1-2 years. I am investigating "affinity column" filtration approach to removing "unwanted materials". I do not want to continue discarding half my plasma long term.
Now that Ambrosia has been bought by Grifols, watch for products derived from "young blood factors".
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Winslow James Foster said:
Ambrosia has been bought by GrifolsAlkahest, not Ambrosia. Very different.
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Dobri's latest interview:
https://daniellelin.com/2021- 06-23-changing-the-landscape- about-alzheimers-dr-dobri- kiprov-private/
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Fred Cloud said:
a topical blue gel product that although he hasnt released any details yet, I will go on the record and predict that it is GHKYou meant GHK-Cu. It is the Copper adduct that causes the signature blue colour of GHK-Cu. GHK(sans Cu) is a white powder.
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You have to search them out, but there are plasma donation centers here in Florida (as opposed to blood donation centers) where you can make two donations a week of 600 yo 800 mls. Simple donation - no saline and albumin replacement. Irina Conboys gene expression data was done on tissues 1 week to a month out from a single 50% dilution and still showed positive changes, so I'm guessing that substantial loss of old plasma in two weeks should show benefit. I am going the route of plasma and platelet donation at my blood bank which I can do every two weeks (they use the donations for cancer patients). Over course of 6 weeks early this year I turned over most of plasma volume. Like most interventions, I am flying blind, but hoping for best. I think Kiprov needs to provide a helluva lot more data (i.e good science) before charging $6,000 for something that should costs him a few hundred in supplies.