The Conboy Plasma-Dilution Treatment is Available Now

    Recently, watching a video interview of Irina Conboy, I became aware that Conboy plasma-dilution for humans is available in San Francisco and Miami from the medical practice of Dobri Kiprov, MD, who works with and has published with Profs. Irina and Michael Conboy of UC Berkeley.  Here are links to videos and writeups about Dr. Kiprov's work on plasma dilution:
https://youtu.be/5gGFJtKIUN0
https://neo.life/2021/06/perspective-therapeutic-plasma-exchange-the-future-of-aging/
https://www.TPEplus.com

    I contacted Dr. Kiprov and had a Zoom call with him this morning.  Here's what I learned:

  • Kiprov's plasma-dilution protocol is slightly different from that described in the Conboy papers.  He adds some proprietary ingredients to the saline + albumin to suppress negative immune reactions.  I suspect that said reactions are caused by a stabilizer component that is in the albumin.
  • Treatment for one person involving two sessions of plasma dilution spaced 2 days apart costs $6,000.  There is a discount if a couple both have treatments at the same time.
  • Several patients have had Horvath-type DNAm bio-age tests before and after treatment.  The apparent epigenetic reset from the treatment is about 3-4 years.  Kiprov does not think the epigenetic reprogramming is "permanent".
  • The effects of the plasma dilution sessions are cumulative, and Kiprov recommends that they be done monthly for about 6 months, with semi-yearly or yearly treatments after that.
  • The observations of recipients are that there are immediate benefits from a plasma dilution session, but they are observed to diminish in a few weeks.  This motivates the repeated sessions.
  • There are plans to set up more centers to perform plasma-dilution treatments at other population centers around the USA.  No decisions yet about where.

    I am considering arranging one set of plasma-dilution sessions for my wife and me next December (for ~$10k), but I don't think we can afford a full 6-month series of them (~$60k).  Also, I am disappointed to learn that the apparent epigenetic reset of the Conboy treatment is only a few years.  According to the paper published with Steve Horvath, Harold Katcher's E-5 treatment on rats produced an epigenetic reset by about a factor of 2.

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  • I and a friend are part of the Conboy/Kiprov - Alzheimer/Fraility study.  We have had six treatments each.  We each had a methylation age reduction.  Each of our treatments was 2.5l replacement with saline/albumin.  We both felt better for a while.

    My significant improvements are known "side effects", lower blood pressure, liver regeneration.  While I did achieve my lowest methylation age reduction of all experimental treatments tried, the Conboys and Kiprov discount this measurement.

    I am considering additional treatments, based on measurements and am adding GrimAge measurements to the mix.

    In my discussion with the Conboy's, they confirmed that blood donation would be a "cheap and dirty" effective approach.  I am supporting a nanotechnology approach to removing "bad stuff" that may come to clinical trial in 1-2 years.  I am investigating "affinity column" filtration approach to removing "unwanted materials".  I do not want to continue discarding half my plasma long term.

    Now that Ambrosia has been bought by Grifols, watch for products  derived from "young blood factors".

    Like 1
    • Lou Hawthorne not now when we were kids, mercery have a 30-60 year half life. wich is intresting due to we see a push in aging at 30 and 60 .... when the half life of the metals are going out and ages us ..... 

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    • Burgundy Summer - Very interesting. I'm looking forward to going down that rabbit hole. It makes sense. I had all the mercury-based fillings removed from my teeth about 10 years back, replaced with composites, and noted an immediate improvement in health, though of course very difficult to attribute to anything specific.

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    • Winslow James Foster Are you taking GDF11 too? It should boost the effect of TPE and fully replicate both arms of parabiosis. 

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    • Fred Cloud I am going to start GDF-11 soon.  Thanks for the suggestion.

      Like 1
  • Winslow James Foster said:
    Ambrosia has been bought by Grifols

     Alkahest, not Ambrosia. Very different.

    Like 1
  • Thanks for the correction.   Grifols also bought an advanced analysis company about the same time.  They are searching for "good factors".

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    • Allen
    • Allen_Rosenberg
    • 3 yrs ago
    • Reported - view

    $6000? It's outrageously expensive. 

    Like 1
    • Allen It is crazy prices - but that's the $ range what the companies are charging in this space:

      Ambrosia was $8,000 for 1 liter, $12000 for 2 liters.

      https://www.businessinsider.com/young-blood-transfusions-ambrosia-shut-down-2019-6

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    • Brin Chikovski Ah - I see they've lowered their prices... such a deal!

      https://www.ambrosiaplasma.com

      Like 1
    • Brin Chikovski Considering they pay the donor only a few hundred dollars, they have a pretty big profit margin. My antiaging doc offered me ambrosia plasma and I told him I was taking gdf11 instead and it totally blew his mind.

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    • Brin Chikovski Ambrosia is shut down by FDA already. That info is obsolete.

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  • Dobri's latest interview:

    https://daniellelin.com/2021- 06-23-changing-the-landscape- about-alzheimers-dr-dobri- kiprov-private/

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    • Jimmy2
    • Jimmy2
    • 3 yrs ago
    • Reported - view

    Can whey protein be a cheap substitute for albumin?  Just give blood and then drink whey protein for amino acids.  Albumin should come back shortly?

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  • Kiprov/Conboy latest publication.

  • Fred Cloud said:
    a topical blue gel product that although he hasnt released any details yet, I will go on the record and predict that it is GHK

     You meant GHK-Cu. It is the Copper adduct that causes the signature blue colour of GHK-Cu. GHK(sans Cu) is a white powder.

    Like 1
  • JGC Hey John, just following up with you on this.

    Did you decide if you are going to do Kiprov plasma dilution or not?

    I am considering it also.

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    • JGC
    • Retired Professor of Physics
    • JGC
    • 2 yrs ago
    • Reported - view

        I decided to pass on Kiprov's procedure.  The deciding factor for me was that treated subjects have reported some benefits that disappear in a few months, but no significant improvement in their DNA methylation epigenetic age.

    Like 2
    • JGC I see. Have you tried the Rejuvant or generic AKG yet?

      Like
    • Peter
    • Peter.2
    • 2 yrs ago
    • Reported - view

    You have to search them out, but there are plasma donation centers here in Florida (as opposed to blood donation centers) where you can make two donations a week of 600 yo 800 mls.  Simple donation - no saline and albumin replacement.  Irina Conboys gene expression data was done on tissues 1 week to a month out from a single 50% dilution and still showed positive changes, so I'm guessing that substantial loss of old plasma in two weeks should show benefit.   I am going the route of plasma and platelet donation at my blood bank which I can do every two weeks (they use the donations for cancer patients).   Over course of 6 weeks early this year I turned over most of plasma volume.  Like most interventions, I am flying blind, but hoping for best.   I think Kiprov needs to provide a helluva lot more data (i.e good science) before charging  $6,000 for something that should costs him a few hundred in supplies. 

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    • Peter I am thinking about doing the same thing. Impressive that you took action and did this, not many people have stepped up and done it. You said you are flying blind, does that mean you arent tracking bloodwork for changes?

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      • Peter
      • Peter.2
      • 2 yrs ago
      • Reported - view

      Fred Cloud  I'm not sure how to check for blood changes which are atributable solely to plasma loss.  I get the standard CBC panel plus hsCRP and plug into Morgan Levines DNAPhenoage.   I show 14 years younger than my age of 67, but am skeptical.  I do other things as well (exercise, TRE, eat well).  I can't say I have a marker that will tell me anything conclusive although several were a bit better (AST and ALT for examle).  I am trying to discipline myself to cycle through a number of things in a systematic way.  I had to dog off donations last 2 months so will start up again soon, and will get blood panel right before and another about 2 weeks after I offload another 3,000 mls.   BTW, for my weight, under 175, my plasma loss is about 440 mls every two weeks.  Irina C did say that tissue changes with routine plasma removal may take a while as it requires turnove of old cells whch occurs at different rates in different tissues.  I'll be looking for change in grey hair and skin over time, hopefully. She also said she doesn't know how long one treatement will last, but as noted in my last post it seems like at least one month.   I intend to go through another intense donation period then settle down with maintenance plasma removal, maybe ~ 600 mls monthly, and I intend to drive to Orlando and try donating at one of the plasma only centers where I can offload half of my plasma in 3 days and see how that works out.  Finally, and this is even more speculative, there is literature which says that plasma proteins are excreted with the water in sweat, along with environmental toxins. The amount of sweat loss is all over the place, but depending on physical exercise and ambient heat coud be as high a couple of liters a day. I intend to take up the plasma protein sweat transfer question with the right kind scientist as well as sweat volume.  Could be that two or three days of intense sauna and exercise might be another good way way to off load old plasma and might be something good to do in the days following a donation, or between donations   I think this would be a great experiment for a lab equipped to assess changes in DNA expression and proteomics.

      Like 1
    • Peter Here are the markers that dropped for the Russian biohackers that donated plasma for dilution. There are duplicates of each marker because there were two subjects, so N=2. Big drops in ALT liver, insulin, inflammation like crp and IL-6, very interesting.

       

       

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      • Peter
      • Peter.2
      • 2 yrs ago
      • Reported - view

      Fred Cloud Thanks.   I do need o be systematic.    I track most of these except for IL-6, oxLDL, and IGF-1.  My hsCRP tends to be low already, always <0.5 as does oxLDL and insulin (about 5).  And AST and ALT were fairly good, upper 20s, etc. so reductions weren't so large.   However, liver improvement is expected as Irina said fibrosis was improved.   

      Like 1
    • Peter By the way, any issues or side effects with the procedure itself? How would you compare it versus donating blood? Just wondering how safe you feel it is.

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