"Senolytic Activator" and Extended Fasting …
Our fine friends at Life Extension have released a new product, Senolytic Activator. It is a combination of Quercertin and Theaflavins. They intend us to use it weekly as a non-prescription version of the Dasatanib + Quercertin senolytic therapy. To fix multiple metabolic issues, I fast. Weekly I have a 24-40 hour fast and monthly I implement a 5 day extended fast. I also implement a 16:8/2MAD time restricted feeding pattern.
My fasting patterns are intended to induce aggressive activation of SIRTuin repair pathways and apoptotic reactions. To that end I supplement with NR. In this context, when should I take the Senolytic Activator? The Life Extension folks formally have no opinion on this question.
This question devolves down to phasing. For example, your body enters a different metabolic regime when your liver depletes its local store of glycogen, between 18 and 24 hours from your last meal. Autophagy rates are postulated to increase; growth hormone starts increasing; a whole panoply of other endocrine systems start shifting. That seems to me to be the likely best time to introduce the Senolytic Activator. SA would provide just the slightest nudge to push senescent cells over into apoptosis. Unless, of course, it is the worst time to introduce SA.
When does this august group think I should take the Senolytic Activator? In phase or out of phase with my fasts?
I also engage in 5 day fasts twice a year, with overnight 12++ hour fasts. I also have the LE Senolytic Activator you mention. Personally I wouldn't take a senolytic activator during a fast, for one reason it would likely kick you out of the fast! Or something to that degree, the activator is not zero calories I assume. Plus your digestive system shuts down and takes a rest, I doubt it would either feel good or effectively digest if you took some supplements. So I recommend using it while not fasting, as I'm doing now.
I'm not overly convinced of the value of the SA product, so I'm testing. At least it's cheap and easy.Reply