I start this thread to avoid polluting the fisetin thread with posts about information about green tea (alone or in combination with other substances). There is plenty of research supporting that combination of green tea and quercetin. I throw in some links to research that I find convincing.
Quercetin increased bioavailability and decreased methylation of green tea polyphenols in vitro and in vivo.
Quercetin increased the antiproliferative activity of green tea polyphenol (-)-epigallocatechin gallate in prostate cancer cells.
Primary Cancer Prevention by Green Tea, and Tertiary Cancer Prevention by the Combination of Green Tea Catechins and Anticancer Compounds. (Table 1)
There are also a body of research that support the use of of Sulforaphane and 3,3′-Diindolylmethane alone or in a combination with green tea.
Effects of Sulforaphane and 3,3′-Diindolylmethane on Genome-Wide Promoter Methylation in Normal Prostate Epithelial Cells and Prostate Cancer Cells. - Wong et al. aimed to evaluate the genome-wide effects of sulforaphane (SFN) and 3,3′-diindolylmethane (DIM) on DNMT1, DNMT3A, and DNMT3B activity and promoter methylation status in normal prostate epithelial cells and LnCAP and PC3 prostate cancer cell lines. For all three prostate cell lines, the authors revealed widespread changes in promoter methylation patterns in response to SFN or DIM interventions. Importantly, SFN and DIM reversed many of the cancer-associated methylation alterations, including aberrantly methylated genes that are dysregulated or are highly involved in cancer progression, such as C–C chemokine receptor type 4 (CCR4), transforming growth factor-β1 receptor type I (TGFBR1), cysteine-rich angiogenic inducer 61 (CYR61), and C-X-C chemokine receptor type 4 (CXCR4).
I have previously used life extensions Triple Action Cruciferous Vegetable Extract but will change to their new optimized cruciferious blend. The combination Green tea, quercetin and sulforaphanee+DIM is a very promising combination for health promotion and disease prevention.Reply
I started drinking green tea decades ago after living in Japan. Better than coffee for me, it does wake me up and calm me down. And yes we've since come to find out the tremendous health benefits.
Tea is the second most drunk liquid on the planet, after water. I wouldn't touch pills, straight from the source gives more benefits, health is body body and spirit.Reply
I'm not sure why this study isn't getting more attention but I think it's very important. It's from the Conboys at UC Berkley:
Recalibrating old blood to be young again
The new study suggests that the majority of aging is driven by changes to a limited number of regulatory signals present in blood. This is a reasonable hypothesis given that the bloodstream is the uniting communication network in the body and that the signals traveling through it do indeed have the potential to influence every cell within the body.
The study focuses on two of the key molecules that influence the ability of stem cells to function and regenerate tissues: TGF-β1, which increases during aging, and oxytocin, which falls during aging. Using a pharmacological approach, they were able to reduce TGF-β1 levels and increase oxytocin, spurring rejuvenation and leading to significantly increased neurogenesis, a reduction of neuro-inflammation, increased cognitive performance, and rejuvenation of the liver and muscle in aged mice.
How do you reduce TGF-b1 levels? How about EGCG and myricetin? See this study:
I'm not sure how you would increase oxytocin. Nasal spray?Reply
The concept of combinations is powerful. As in basic chemistry.
Also as powerful are cycles in the body. Like wash THEN dry. Not at the same time.
I think we need to test some of these combinations in cycles. Like D for two days followed by Q for two. Or D+Q, followed in some time ( 3 days?) by large doses of Fisetin or equivalent.
Thoughts by all on cycles?Reply
If you decide to try Ferulic acid then I am very interested to learn about your experience. I will try Ferulic acid + EGCG myself, but not right now. I have quite a few potentially health promoting and anti-aging interventions that I want to add to my regime before I try Ferulic acid. To find out what works on an individual basis means adding one intervention at the time so Ferulic acid will have to wait for a while. For me to learn if ferulic acid really can assist EGCG with ameliorating the symptoms of AD would be very relevant knowledge. Even if it is only done by one person that’s how pioneering is done. And that is were we are right now. Whatever you decide to do, Good luck. And yet again thank you for sharing your EGCG dosing.Reply