How to increase the bioavailability of Fisetin
I'm preparing to do a Fisetin senolytic experiment, but I've read on the article from Mayo Clinic ( https://linkinghub.elsevier.com/retrieve/pii/S2352396418303736 ) that the administration mode was done through a mix of phosal and other stuff :
100 mg/kg of fisetin in 60% Phosal 50 PG:30% PEG400:10% ethanol
So the bioavailability of the Fisetin should be a key step for the treatment. I am looking for some information on how to increase the Fisetin bioavailability. Does anyone know of some methods to do this ?
110 replies
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Ajax Regarding the taste of fisetin when placed sublingually, if you take a miracle fruit tablet first and let it dissolve under the tongue, it seems to dial down the fisetin taste. I tried it just now and plan to continue it daily (500 mg/day) for the next few months to see if there's any effect.
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Now that I think about it, since fisetin is fat soluble, it would make sense to dissolve it in, say, some olive oil and put that under the tongue. It would absorb faster than just using the dry powder. It took over an hour for the stuff to get absorbed when I tried it.
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Maximum absorption can be had by mixing it with oil, placing it in a capsule and inserting it into the rectum.
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@jgc I've been taking/experiencing a fisetin combo for a few months now : doctor's best(3to4)+revgenetics(2to3) and noticed much better effect or absorption(?) than any of them alone then that is on a weekly basis 3 to 4 days out of 5!
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Anybody taking the fisetin with olive oil feels any good effect?