Paul's self experimentation
I inadvertently started on this 5 years ago when I started taking Metformin. Was diagnosed with a Gleason 6 prostate cancer. Docs didn't want to treat just monitor. Found that diabetics taking Metformin had a very low chance of dying from PC.
Just found this site after reading David Sinclairs book LifeSpan and put blood test results into Aging.AI and result was predicted age of 49. I'm 67.
I've suffered from TMJ for years and as a result don't eat a lot - kind of a caloric restriction, so I think that may have an impact on predicted age from what I've read.
My wife put her test results into Aging.AI and her predicted age was 59. She is 55.
We have an active lifestyle and bike, hike or walk every day. But she doesn't take MEtformin and she eats a lot more than me though she is quite fit.
I just started taking Rapamycin two weeks ago, so will be interesting to see if that has an effect
Update on blood work after 3 months on Rapamycin and one D & Q treatment.
For about 5 years now I've been getting poor results on kidney functions - low eGfr and high creatine. My grandfather and aunt both died of kidney disease, so i figured that was hereditary.
My eGfr increased from averaging 52 to 89 and my Creatine dropped from 1.41 to 0.88
I am ecstatic about these results! Didn't exercise much over the last 3 months either due to winter, so maybe able to improve.
Using the Levine spreadsheet provided by others on this forum my predicted DNAage dropped from 63.5 with last years blood work to 51.3. Hopefully there is some validity to this! Best part is my predicted mortality risk dropped from 16.6% to 5.8% over the next 10 years
I've had a second set of blood tests done in June to confirm Feb results and they were pretty close.
Had high Total Cholesterol and LDL-c but my HDL was over 70 and my triglycerides were under 70. My ratio of Tot C/HDL was good at 3.3 and Trig/HDL was 1.1 also good. LDL-p was quite low. I do a low carb/high fat diet so this was expected and despite my doctors insistence, I see no need for a statin.
I started on a 30 M rapamycin skin cream about 30 days ago. Wrinkles look better but very hard to quantify.
I also started on 150 pg of GDF11 this week.
Started my current experimentation 12/1/19
Did a DNA methylation test and it matched my chronological age of 66. The Levine spreadsheet showed 63 from 2019 blood tests.
After 7 months of weekly rapamycin and a one time D&Q treatment the Levine sheet showed my age as 53.2 (up from 513 in Feb - I took the D&Q in Jan)
And my DNA methylation test nearly matched the LEvine blood test age - 52.2
So, I must be doing something correct.
Hello, Paul, thanks so much for sharing.
I'm very interested in taking metformin. I'm only in my mid-30's, avg body weight, but have a strong history of cancer (albeit not at particularly young ages) in my family. Does anybody have any advice on how to start in terms of dosage and where to get it?
Also, how do you get the DNA methylation test?
I am 38 and got metformin from agelessrx. i have decided to only take it on the weekends. I have been wearing a cgm (they sell them as well) to track my glucose. Having also tried finger pricks, i can tell you that without a cgm its very difficult to track the rise/peak after eating, as its not consistent. I would recommend wearing a cgm for atleast one cycle of 14 days
David H said:
Adrian M YMMV, but I don't believe that hypoglycemia is a problem with metformin. Metformin works by reducing absorption of carbohydrates and by reducing the amount of fat converted into glucose. It's not like taking insulin or other diabetic drugs.
You will need to convince your doctor that the anti-aging benefits are sufficient reason to take metformin. In the USA, a doctor prescribing metformin for anti-aging is said to be prescribing it "off label" which means a purpose for which it is not FDA approved. Anytime a doctor prescribes off label, I presume that they have more risk to themselves (from legal liability and from problems with the medical boards). Yet, some do prescribe metformin for anti-aging.
Here's a link from these forums about how to approach MD's about anti-aging:
I bought a Bayer Contour Next EZ Glucose Meter. It is very inexpensive but the test strips are expensive. You prick yourself with a little device and put a little of the blood on a test strip.
According to this link https://twitter.com/PeterAttiaMD/status/1207363088325976064 I misunderstood Dr. Attia. This twitter posting he made in December 2019 says an average of 100. Not max of 100.
Here is another link for Dr. Attia's view on the subject:
Goals = Fasting glucose below 90, 1 hour post prandial <120-130, 2 hour glucose below 100 (post prandial means after a meal or eating)
Hi David, sorry for the delay.
I think hypoglycemia was mentioned somewhere as a rare side effect so I wouldn't worry too much about it.
Thanks for the links. I'll try talking to the doctor about it but it's very doubtful they'll take the chance. Is ageless.rx a good source of obtaining it without a prescription?
Why don't you use a device that you put only once under your skin that you can keep scanning with your phone to get a glucose reading rather than having to repeatedly prick yourself? Sinclair mentions the one he uses in this recent lecture: https://youtu.be/eaS82uJER-I
Thanks a million for the links and glucose guidelines, very helpful.
May I ask, when you started taking metformin, was it a gradually increasing dose? I.e., did you start with 1000 or 500 and gradually climb to 2000? PS is your wife taking it too?