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Metformin: worth it? and what to expect
Hello all. I got my Doctor to give me a prescription for Metformin. I have read about its possible age-reversing effects, but I have also read about some possible significant side effects,…
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Kaufmann Protocol Analysis
Dr. Sandra Kaufman, an MD anesthesiologist with an interest in aging, wrote a 2017 book entitled The Kaufmann Protocol: Why We Age and How to Stop It, in which she describes her approach to…
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Should you get a micronutrient test?
Imagine my excitement as the moment finally arrived - the comprehensive results from my 15 vials of blood and four detailed blood tests that I completed at NextHealth arrived in my inbox.…
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Relaxin (RLX)
Hi Everyone, Has anyone looked at sourcing & using RLX? I've had an AVR operation 8 months ago & my EF has gone from 67 (12 months pre-op) to 55 (pre-op) to 35 (post-op).…
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Ursolic acid
I am curious about this substance - Ursolic acid. I wonder if there are people in here that have first hand experience from the use of Ursolic acid. I post a link to a review from 2018.…
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enhancing NAD precursor effectiveness
Therapeutic doses of NR and NMN in studies are usually much larger than the suggested amount on the label. Chromadex NR studies usually use a gram or more of the stuff,…
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Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism
Not sure how to take this. Anyone more knowledgeable care to comment? https://www.biorxiv.org/content/10.1101/863357v1
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Telomerase Activators
I couldn’t find discussions about the available telomerase activators such as Isegenesis, TA-65, and Defytime Aging Care Capsules (previously named TAM-818,…
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Serrapeptase headaches
Serrapeptase and proteolytic enzymes cause headaches over a very long period of time. I think the headaches may be caused primariy by the brain's attempts to get rid of the debris left behind after…
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GDF11 rejuvenation
Has anybody here participated with GDF11 Rejuvenation? Results, experience?
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Sources for Metformin?
Suggestions? The best source is via your GP. I have script for Metformin due to an undiscovered elevated glucose (check yours first thing in the morning,…
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Ferulic acid
How to use ferulic acid and where to buy ferulic acid as supplement for oral use? My plan is to try Ferulic acid and EGCG (Green tea). My aim for this experiment is to see if this combo can clear…
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Beacon pharmaceuticals Ltd
I wonder if there is someone in here that has experience of dasatinib bought directly from Beacon pharmaceuticals Ltd, Bangladesh. https://www.beaconpharma.com.bd/?attachment_id=15948 https://en.…
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Dasatinib from Bon Hoa
A couple weeks ago, I placed an order for Lucius Dasatinib from Bon Hoa. So far, I've taken 200 mg on two consecutive days. It had zero effect on me...no nausea, no tiredness, nada.…
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Biological Age = 31.3y, Chronological Age = 46y
https://michaellustgarten.com/2019/11/01/biological-age-31-3y-chronological-age-46y/
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What biomarkers and objective measures for results of your age management therapies do you have?
Who has before and after biomarker and/or objective measurement evidence demonstrating the effectiveness of any aging intervention therapy in humans? Measures might include: DNA methylation,…
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Christine's Self experiment
I'm going to test a combination of Rapamycin, Q+T, Metformin and Nicotinamide Riboside. I'm a 38 year old woman and this is what I gather to be a full set of supplements for the 35-55 age group.…
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Optimizing Biological Age: Albumin
https://michaellustgarten.com/2019/09/22/optimizing-serum-levels-of-albumin-data-from-20-blood-tests/
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The conventional CVD/lipid hypothesis: challenged
The conventional mainstream lipid hypothesis suggests high cholesterol is directly associated with elevated CVD risk. High plasma cholesterol diffuses into the endothelial space via the LUMEN,…
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Phosphatidylcholine
Not a lot about Phosphatidylcholine supplementation. Ray Kurzweil is a huge fan as stated in his Transcend book, see that for the why's and wherefores (basically you stop producing it as you get…
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Did this paper about D + Q and tumorigenesis concern anyone here?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218402/ Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death, which develops in the context of fibrosis and cirrhosis caused by…
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immediate release Metformin (irM) possible side effect: bladder/ prostate irritation
I started taking metformin about 1.5 months ago [2x500mg/day] and have noticed an increased urge to urinate. my bladder or prostate, possibly both, seems to react in a very bad way.…
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Young plasma treatments in Tampa, Florida
My name is Howard Chipman MD and I have been treating patients with young plasma for anti-aging, dementia and other age related disorders for over a year with good results.…
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The purity of Lucidias-brand Dasatinib
Last year I obtained a 60-tablet bottle of 50 mg Lucidias-brand Dasatinib from BonHoa Pharmacy in New Deli, India, link https://www.bonhoa.com. It seems to be manufactured by Lucius Pharmaceuticals…
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Rapamycin
I have done bio identical hormones for 3 1/2 months before I start Rapamycin. Do I take 5 mg once a week for 3 months and then take a month off and start again?
Share your story of trying or designing a promising age-reversal protocol.