Kaufmann Protocol Analysis

    Dr. Sandra Kaufman, an MD anesthesiologist with an interest in aging,  wrote a 2017 book entitled The Kaufmann Protocol: Why We Age and How to Stop It, in which she describes her approach to anti-aging and provides a qualitative method of assessing the effectiveness of various anti-aging supplements.  In particular, she defines seven "tenets", i.e., physiological issues that need to be addressed in combating the negative effects of aging, and gives each supplement a score of 0 to 3 as a measure of its effectiveness in each of these categories.  On the Kaufmann Protocol website, a list of possible supplements and their scores is provided, and I have captured these values to use in my spreadsheet.

    I was curious as to how I am doing with the supplements I'm presently taking daily, in terms of the Kaufmann Protocols, so I made a spreadsheet.  It can be downloaded from this LINK.   It sums the Kaufmann scores of the supplements you are presently taking and provides a net score.

    In the blue "Taking?" column, you simply put a "1" indicating the supplements you are taking (while leaving the others blank), and the spreadsheet will calculate your Kaufmann Score.  As indicated by my 1s in the spreadsheet , my current score is 80, which is pretty good.

    I note that three supplements that I am interested in (fisetin, rapamycin, and dasatinib) were not on her list, so I estimated the Kaufmann scores for these, as indicated by "JGC Estimates".  The dose values in the spreadsheet are mostly those listed in the book.

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  • I cannot view this or the link to the spreadsheet. Appreciate you creating it but I don't think the way you shared works

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      • JGC
      • Retired Professor of Physics
      • JGC
      • 4 yrs ago
      • Reported - view

      Paul Beauchemin 

      The link works for me.  You click on it, and an image appears.  On the upper right, you click on "Open" and it opens in MS Excel.  This you can save to your machine.

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      • David H
      • David_Hanson
      • 4 yrs ago
      • Reported - view

      JGC Not working for me - first I had an error that you had run out of download data quota. Now the error is

      Error (404)

      We can't find the page you're looking for.

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    •  JGC here’s the Dropbox troubleshooting page. I wonder if your links were banned https://help.dropbox.com/files-folders/share/shared-link-stopped-working

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    • Karl
    • Karl.1
    • 4 yrs ago
    • Reported - view

    I have not read her book, but have gone through the website.  I think her choice of supplements is a bit arbitrary, with key supplements as you mentioned missing.  I would not worry about how well you are meeting her criteria.

    Like 1
    • JGC
    • Retired Professor of Physics
    • JGC
    • 4 yrs ago
    • Reported - view

    Some have had problems accessing my Kaufmann Protocol spreadsheet from DropBox.  Here's an alternative link on the MS Cloud:

    https://1drv.ms/x/s!Ap3rYYlMocgZgYgySEGElib0GZrwNA?e=IxrT3t

    Hope that works.

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    • JGC thanks works perfectly 

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    • Dan Nave
    • Dan_Nave
    • 4 yrs ago
    • Reported - view

    If you are taking alpha lipoic acid for brain mitochondrial protection you may want to combine it with acetyl-L-carnitine.  Check out this link.

    Combined R-α–lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson’s disease.

    https://www.ncbi.nlm.nih.gov/pubmed/20414966

    It says: "Most notably, we found that when combined, LA and ALC worked at 100–1000-fold lower concentrations than they did individually."

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      • Danmoderator
      • skipping my funeral
      • dantheman
      • 4 yrs ago
      • Reported - view

      Yes, Dr Bruce Ames discovered this (of the famed Ames test which is used to test if substances are carcinogenic). There are videos you YouTube of him giving entertaining talks discussing the work. Fifty year old equivalent mice acting like younger ones on the combination, they work to restore mitochondrial function. 

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