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How do I compound my own NAD+
Hello, I am soon to be 50 male, have chronic mental fatigue, but otherwise “healthy”: no currently diagnosed disease. I am looking into buying NAD powder to use half of it sublingually,…
- Abdenour Achab
- Abdenour_Achab
- 6 yrs ago
- 2replies
- 304
- 1
- Last replyRICH5 yrs ago
- NAD+ Restoration
Sleep
Research has shown that sleep is the basis for our health (see anything by Matthew Walker, such as Why We Sleep on the topic.) Additionally from aging research we know the benefit of melatonin,…
- Danmoderator
- skipping my funeral
- dantheman
- updated 5 yrs ago
- 1reply
- 108
- 1
- Last replyChan5 yrs ago
- General Discussion
Retinal imaging
UHB Trust / Getty Images A test to add to your regime; Retinal imaging. My optometrist does this for us, and since I have a strong prescription it's an excellent idea to monitor as retinal tears are…
- Danmoderator
- skipping my funeral
- dantheman
- updated 5 yrs ago
- 2replies
- 175
- 1
- Last replyDanmoderator5 yrs ago
- Test Results Discussions
The conventional CVD/lipid hypothesis: challenged
The conventional mainstream lipid hypothesis suggests high cholesterol is directly associated with elevated CVD risk. High plasma cholesterol diffuses into the endothelial space via the LUMEN,…
- MAC
- MAC
- 5 yrs ago
- 2replies
- 72
- 1
- Last replyMAC5 yrs ago
- Self-Experimentation
Exercise and AMPK activation.
How to exercise to achieve the greatest health benefits. And what experiences do we have. Exercise promotes AMPK activation. Exercise is such a powerful factor for creating health promoting and…
- Staffan Olsson
- Staffan_Olsson
- 6 yrs ago
- 2replies
- 324
- 1
- Last replyStaffan Olsson5 yrs ago
- AMPK Activation
Phosphatidylcholine
Not a lot about Phosphatidylcholine supplementation. Ray Kurzweil is a huge fan as stated in his Transcend book, see that for the why's and wherefores (basically you stop producing it as you get…
- Danmoderator
- skipping my funeral
- dantheman
- 7 yrs ago
- 1reply
- 228
- 1
- Last replyMAC5 yrs ago
- Self-Experimentation
Why not age?
We talk a lot about how to prevent aging, let's take a look at why we're doing it? Three specific questions When was the first time (your age and circumstances) when you decided you didn't want to…
- Danmoderator
- skipping my funeral
- dantheman
- 5 yrs ago
- 5replies
- 73
- 1
- Last replyJennifer Johnson5 yrs ago
- General Discussion
Commemorative plaque for the discovery of Rapamycin
Something different, a plaque was put up commemorating the discovery of Rapamycin on Easter Island, apparently at the location of where it was found. If you happen to be visiting Easter Island it…
- Danmoderator
- skipping my funeral
- dantheman
- updated 5 yrs ago
- 72
- Rapamycin Discussion
Personal testing regimen?
Hi everyone, I'm wondering: what kind of biomarkers do you all test, to assess whether self-experimentation is slowing degenerative aging? Personally, I've been very focused on studying insulin…
- Maximus Peto
- Researcher, website & forum admin
- Maximus
- 7 yrs ago
- 17replies
- 454
- 1
- Last replyaribadabar5 yrs ago
- Assessing Biological Age
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin
https://www.ebiomedicine.com/article/S2352-3964(19)30591-2/fulltext
- Larry
- Larry.1
- 5 yrs ago
- 2replies
- 163
- Last replyLarry5 yrs ago
- Senolytics Discussion
Disease Prevention and Treatment, 6th ed
Disease Prevention and Treatment 6th edition is out. Only $10 on Kindle. This should be your go-to reference on protocols for disease prevention, life extension and increasing your health span.…
- Danmoderator
- skipping my funeral
- dantheman
- updated 5 yrs ago
- 1reply
- 111
- Last replyRob83115 yrs ago
- Announcements
Did this paper about D + Q and tumorigenesis concern anyone here?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218402/ Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death, which develops in the context of fibrosis and cirrhosis caused by…
- Phoenix
- phoenix
- 5 yrs ago
- 4replies
- 154
- Last replyDanmoderator5 yrs ago
- Self-Experimentation
Bad doctor visits
As a companion to my thread on tips for navigating the medical system I thought it would be useful to relate some stories about bad visits to the doctor, from me and others.…
- Danmoderator
- skipping my funeral
- dantheman
- updated 5 yrs ago
- 2replies
- 36
- 1
- Last replyDanmoderator5 yrs ago
- General Discussion
Any Meetup group in Orlando, FL area?
- Suzan
- Suzan
- 5 yrs ago
- 42
- North America Meetups
immediate release Metformin (irM) possible side effect: bladder/ prostate irritation
I started taking metformin about 1.5 months ago [2x500mg/day] and have noticed an increased urge to urinate. my bladder or prostate, possibly both, seems to react in a very bad way.…
- Cristian Lapusan
- Cristian_Lapusan
- updated 6 yrs ago
- 1reply
- 113
- Last replyShauna5 yrs ago
- Self-Experimentation
Peripheral neuropathy?
Any ideas on dealing with this? An unfortunate possible side effect of an antibiotic my wife was on and now she's experiencing it. We're looking at the following neurological supplements Acetyl L…
- Danmoderator
- skipping my funeral
- dantheman
- 6 yrs ago
- 21replies
- 274
- 1
- Last replyMike Almerjanski5 yrs ago
- General Discussion
Social isolation and loneliness: A more serious risk factor than many realize?
Hi everyone, I'd never looked seriously at the correlative data linking social isolation with bad health outcomes because I always assumed the real driver of the effect was already existing…
- BrianMDelaneymoderator
- BrianMDelaney
- 7 yrs ago
- 5replies
- 242
- 1
- Last replyhermes liberty5 yrs ago
- General Discussion
Tips on age reversal clinics and facilities to visit in Asia, Middle East, Europe
Just posted this to Facebook, but thought I'd put it here, as well: Friends, I'd love tips on researchers/clinics/facilities in the age-reversal realm I might want to visit on my upcoming…
- BrianMDelaneymoderator
- BrianMDelaney
- 6 yrs ago
- 4replies
- 143
- Last replyhermes liberty5 yrs ago
- General Discussion
Vitamin patches from WebMD
After my experience using Rx NAD electrophoresis patches I am interested in what else can be done here and came across the WebMD Omega-3 patch. It has a nice cocktail of anti aging supplements…
- Danmoderator
- skipping my funeral
- dantheman
- 6 yrs ago
- 4replies
- 129
- 1
- Last replyMike Almerjanski5 yrs ago
- General Discussion
'Increased NAD+ metabolism may enhance secretory activity of senescent cells in a way that promotes tumor progression'
https://medicalxpress.com/news/2019-02-insight-tumor-suppressive-tumor-promoting-effects-cellular.html The report on the study here has me re-examining my NR usage,…
- Applied Extropy
- Heralding our Apotheosis
- Applied_Extropy
- 6 yrs ago
- 3replies
- 257
- 1
- Last replyAllen Whipps5 yrs ago
- NAD+ Restoration
2
Add a WIKI to the site
We should have a 'WIKIpedia of aging intervention' where we can organize and pool our collective information. I would pour everything I've learned into it, admins?
- Danmoderator
- skipping my funeral
- dantheman
- 6 yrs ago
- 6replies
- 198
- 2
- Last replyMike Almerjanski5 yrs ago
- Ideas
What happens when I stop taking nicotinamide?
I am finishing my first bottle of nicotinamide carboside, I am 56. My question is what will happen if I just stop, will I get my lowest NAD levels ever? and for how long.
- qsr
- qsr
- updated 5 yrs ago
- 1reply
- 202
- 1
- Last replyDanmoderator5 yrs ago
- NAD+ Restoration
The vagaries of lab testing
I've done hormone testing in two labs; LabCorp and my health care provider which has it's own in-house test lab. It was distressing to see my LabCorp numbers continue to drop after starting…
- Danmoderator
- skipping my funeral
- dantheman
- updated 6 yrs ago
- 14replies
- 181
- Last replyDanmoderator5 yrs ago
- Test Results Discussions
As a layperson, I find all of this frustrating and intimidating
Suppose anyone were to ask me how to go about benefitting from this website and/or this forum, I would not be able to tell them. And I am doing due diligence, or at least trying to.…
- Aaron Agassi
- Aaron_Agassi
- 6 yrs ago
- 21replies
- 188
- Last replyMike Almerjanski5 yrs ago
- General Discussion
Bad News. List of drugs that may cause senitlity or alzheimer's in seniors
https://edition.cnn.com/2019/06/24/health/dementia-risk-drug-study/index.html https://www.theseniorlist.com/medication/anticholinergic-drugs/ If you are 60 or older, this affects you.…
- Bernie
- Bernie_Singer
- 6 yrs ago
- 2replies
- 164
- Last replyEdward Sutherland5 yrs ago
- General Discussion

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