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How do I compound my own NAD+
Hello, I am soon to be 50 male, have chronic mental fatigue, but otherwise “healthy”: no currently diagnosed disease. I am looking into buying NAD powder to use half of it sublingually,…
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Sleep
Research has shown that sleep is the basis for our health (see anything by Matthew Walker, such as Why We Sleep on the topic.) Additionally from aging research we know the benefit of melatonin,…
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Retinal imaging
UHB Trust / Getty Images A test to add to your regime; Retinal imaging. My optometrist does this for us, and since I have a strong prescription it's an excellent idea to monitor as retinal tears are…
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The conventional CVD/lipid hypothesis: challenged
The conventional mainstream lipid hypothesis suggests high cholesterol is directly associated with elevated CVD risk. High plasma cholesterol diffuses into the endothelial space via the LUMEN,…
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Exercise and AMPK activation.
How to exercise to achieve the greatest health benefits. And what experiences do we have. Exercise promotes AMPK activation. Exercise is such a powerful factor for creating health promoting and…
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Phosphatidylcholine
Not a lot about Phosphatidylcholine supplementation. Ray Kurzweil is a huge fan as stated in his Transcend book, see that for the why's and wherefores (basically you stop producing it as you get…
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Why not age?
We talk a lot about how to prevent aging, let's take a look at why we're doing it? Three specific questions When was the first time (your age and circumstances) when you decided you didn't want to…
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Commemorative plaque for the discovery of Rapamycin
Something different, a plaque was put up commemorating the discovery of Rapamycin on Easter Island, apparently at the location of where it was found. If you happen to be visiting Easter Island it…
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Personal testing regimen?
Hi everyone, I'm wondering: what kind of biomarkers do you all test, to assess whether self-experimentation is slowing degenerative aging? Personally, I've been very focused on studying insulin…
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Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin
https://www.ebiomedicine.com/article/S2352-3964(19)30591-2/fulltext
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Disease Prevention and Treatment, 6th ed
Disease Prevention and Treatment 6th edition is out. Only $10 on Kindle. This should be your go-to reference on protocols for disease prevention, life extension and increasing your health span.…
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Did this paper about D + Q and tumorigenesis concern anyone here?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218402/ Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death, which develops in the context of fibrosis and cirrhosis caused by…
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Bad doctor visits
As a companion to my thread on tips for navigating the medical system I thought it would be useful to relate some stories about bad visits to the doctor, from me and others.…
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immediate release Metformin (irM) possible side effect: bladder/ prostate irritation
I started taking metformin about 1.5 months ago [2x500mg/day] and have noticed an increased urge to urinate. my bladder or prostate, possibly both, seems to react in a very bad way.…
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Peripheral neuropathy?
Any ideas on dealing with this? An unfortunate possible side effect of an antibiotic my wife was on and now she's experiencing it. We're looking at the following neurological supplements Acetyl L…
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Social isolation and loneliness: A more serious risk factor than many realize?
Hi everyone, I'd never looked seriously at the correlative data linking social isolation with bad health outcomes because I always assumed the real driver of the effect was already existing…
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Tips on age reversal clinics and facilities to visit in Asia, Middle East, Europe
Just posted this to Facebook, but thought I'd put it here, as well: Friends, I'd love tips on researchers/clinics/facilities in the age-reversal realm I might want to visit on my upcoming…
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Vitamin patches from WebMD
After my experience using Rx NAD electrophoresis patches I am interested in what else can be done here and came across the WebMD Omega-3 patch. It has a nice cocktail of anti aging supplements…
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'Increased NAD+ metabolism may enhance secretory activity of senescent cells in a way that promotes tumor progression'
https://medicalxpress.com/news/2019-02-insight-tumor-suppressive-tumor-promoting-effects-cellular.html The report on the study here has me re-examining my NR usage,…
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Add a WIKI to the site
We should have a 'WIKIpedia of aging intervention' where we can organize and pool our collective information. I would pour everything I've learned into it, admins?
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What happens when I stop taking nicotinamide?
I am finishing my first bottle of nicotinamide carboside, I am 56. My question is what will happen if I just stop, will I get my lowest NAD levels ever? and for how long.
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The vagaries of lab testing
I've done hormone testing in two labs; LabCorp and my health care provider which has it's own in-house test lab. It was distressing to see my LabCorp numbers continue to drop after starting…
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As a layperson, I find all of this frustrating and intimidating
Suppose anyone were to ask me how to go about benefitting from this website and/or this forum, I would not be able to tell them. And I am doing due diligence, or at least trying to.…
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Bad News. List of drugs that may cause senitlity or alzheimer's in seniors
https://edition.cnn.com/2019/06/24/health/dementia-risk-drug-study/index.html https://www.theseniorlist.com/medication/anticholinergic-drugs/ If you are 60 or older, this affects you.…