Personal testing regimen?
I'm wondering: what kind of biomarkers do you all test, to assess whether self-experimentation is slowing degenerative aging?
Personally, I've been very focused on studying insulin sensitivity over the past several years. So I test fasting glucose, fasting insulin, and IGF-1. I'm also increasingly convinced that LDL-C or ApoB is a useful biomarker for atherosclerosis, so I regularly test my LDL-C. I test these biomarkers around 3 times per year.
What do you regularly test?
Nothing at the minute. Probably the crux of how things must change generally & for me. Widening the question. Do you/anyone partake in health screening. In UK the NHS provide Bowel Screening for cancer/AAA Screening for Aneurism/ & usually Blood Pressure & Cholesterol Levels, so I get those. Ladies get other tests.
But have wondered what biomarkers /additional screening I should partake in. Indeed where to get it ? Also accuracy ? Prostate cancer treatment & diagnosis would seem to leave a lot to be desired. Would like to know if there is a reliable vascular check that could be undertaken, Know too many people who have had fatal or devastating first heart attacks. Believe 90% of people follow instinctive anti-aging protocol. What is happening here seems a big step in the science approach.Reply
Maximus, I always ask my PC to test everything possible that could effect my life quality and lifespan. He knows I'm a life-extensionist. Fortunately, my health insurance has covered all the tests he says can benefit me, except for LDL particle size. He said that would cost me out of pocket in the hundreds, I think. He always tests for fasting blood glucose, requiring a 12 hour fast. That's been running around 90 for years so I know I need to improve that. He's happy with my cholesterol levels. I know my triglycerides are good but my LDL last was about 130, which is not good, but my HDL was good, over 50, and he said that makes up for the LDL not being optimal. He also said they're not doing homocysteine testing anymore because of false readings, which is odd to me because I've read more than once in the past year that it should be tested. He also tests for CRP, which I know is not optimal and I need to address that better from now on. Also he tests for the blood cells, calcium,and my Vit D, he said was a little low last time, and other nutrients/minerals/vitamins and I think for DHEA and cortisol, eosinoprils, hormones...it's always a long list but I'm always trying to add to it. :)Reply
USA2Elsewhere It sounds like you've been doing some important testing.
One concern I have in your story is that I understand LDL of 130 to definitely be higher risk for heart disease, atherosclerosis and stroke. HDL of 50 does not make up for that. A good target for LDL is under 70, and even under 50 if you can do it.
I recently achieved LDL of under 70 with just diet and supplements (no statin). It involves a lot of soluble fiber, eating a lot of cooked barley with fruit and yogurt, and beans in the evening (in chili and salads). I also take 2 g/day of plant sterols and 500 mg of niacin in the AM.
I hope you can get that LDL down!
I watched a good intro video about LDL-C at this website: http://plantpositive.com/
There are a lot of videos there, and I didn't watch them all. But learning how people with genetically low LDL have much lower rates of heart attacks, and how hunter-gatherer tribes with low cholesterol basically don't have heart disease, helped convince me to get my LDL down.Reply
Testing has been difficult - it's absolutely ridiculous that you have to get your stupid physician to approve a blood test. All they do is look at the actual versus nominal results, and only earn their keep if you want to take medication for some condition. So for a long time I've been searching for away to easily get some blood work done, and happily discovered that Life Extension.com offers lots of tests. At the moment I'm trying the "Male Elite" test to see how it goes.
Otherwise the test I relied on the most was Homocystein, it's my belief that this marker of inflammation is the best indication of overall health. Otherwise all my numbers are in the green or better. By better I mean better than their nominal - for example with the white blood cell count. I'm a whole foods vegan and follow a health regime, commonly people like me have 'low' platelet counts. Reason being the nominal values are too high as they account for the general population that has high inflammation and other issues which stress the immune system and raise the WBC count.
Speaking of the uselessness of physicians on this, for years I had to listen to them get worried about the cell count. Early on before I knew the score they'd send me off to get an AIDS or cancer test, since those two can lower your WBC count.
Otherwise I have a MTHFR variant and take methylfolate, which I monitor because it has a tendency to get a bit too high from the supplementation (I also check D since I supplement with that too).Reply
Have been testing mostly all what is mentioned here and this for 20+ years. Importantly hormones and particularly their axis ratios. Feel patterns and trends are possibly even more important than single biomarkers validated in the clinic. Key is the link to morbidity and mortality capturing the complexity of underlying biochemistry.Reply
Reading Bill Faloon's presentation at RAAD2018. Do you know the details of the blood markers suggested to be measured. I can guess some of the most important, e.g. hr-CRP for "inflammatory" but there many more. Unless I overlooked, only the category are given (at p. 16), i.e.:
• INSULIN RESISTANCE
• IMMUNE FUNCTION
• THROMBOTIC RISK
• GLYCEMIC MARKERS
• LIPIDS (FULL-SPECTRUM)
• GROWTH FACTORS
• BLOOD CELL COUNTS
• VITAMIN D STATUS