Interesting idea Dan. And I appreciate your willingness to contribute. I have the impression that you know more than a few things about this topic, and have plenty to contribute.
I'm torn about it. On the one hand, I think it would be wonderful to have a well-referenced, well-organized wiki of all of the various promising interventions.
On the other hand, if we are not very careful about setting out the rules ahead of time and inviting only very specific people to enter data only according to those rules, we may end up with a poorly referenced, poorly organized mess of ideas, including everything from rigorous studies of CR in primates, to butter coffee from the Bulletproof diet and ketogenic recipes from Livin la Vida Low Carb.
Given these challenges, I'm highly reluctant to start and organize a wiki. But that could be an interesting project at some point.Reply
Agreed on the benefit to a Wiki, as so much may be lost in long forum threads. However, H+Pedia already has a Longevism section of their wiki. Utilising that instead would tap into their contributor base: https://hpluspedia.org/wiki/Main_PageReply
A Wiki would be valuable, and it would be a huge amount of work. And endlessly in need of updating, too.
How about a software solution to the problem? I'm using an Artificial Intelligence (A.I.) search program for this purpose -- and it works pretty well: DevonAgent Pro.
For example, I searched for "Fisetin" and got this concept map plus the following text summary. Total time, about 3 seconds. The text summary is far from perfect or complete, but at 3 seconds, I'm not complaining.
Clicking any node on the concept map immediately produces a summary for that topic along with a fresh concept map centered on that topic. (That doesn't work here -- this is just a screen print to show the map.) Plus, the software will search and update automatically on any schedule you set: 1 day, 2 weeks, etc.
Another advantage of using A.I. software like this it it greatly eliminates the personal "chatter" that tends to fill forum posts, especially forums on health topics.
Finally, the software could search multiple web sites simultaneously, and produce a composite of all of them: both the topic map and the text summary.
I don't want to clutter up this topic with detailed discussions about software. So if you or anyone else is interested, you are welcome to send a private message to me. DevonAgent Pro is a commercial product. I'm a customer, but otherwise not connected in any way.
This concept map is created FROM this forum, but not BY the forum:
Same with the summary below. The source is forum posts, but the summary was created entirely by the A.I. software.
Cell Death Mechanisms Behind D+Q and Fisetin Senolytics - Self-Experimentation - Age Reversal Forum
After having done about 9 months of self-experimentation with the effects of D+Q and Fisetin senolytic burst-treatments, I and others in my family have noticed that senolytics with D+Q tends to induce transient flu-like symptoms and a half-day or so feeling of un-wellness, while Fisetin, even taken in 2,000 gram/day doses, does not.
The research on mice indicates that the two senolytic treatments have roughly the same level of senolytic effectiveness. Therefore, I speculate that in the D+Q treatment the immune system is going autophagous, destroying the senescent cells while leaving behind considerable symptom-producing molecular debris, while the Fisetin treatment is triggering aptosis, the natural dismantling of cells that is relatively clean, with little leftover molecular debris.
I have not tried D+Q yet. When I do Fisetin as single treatment I don’t feel any negative effects. But when I have tried Fisetin in combination with other substances I have felt unwell and had Headache and pain in muscles. (Different ombinations with Piperine/piperlongumines/tocotrienols/quercetin).
Yes it could be that fisetin starts a “cleaner” process. But I also speculate that the fluelike symptoms that is reported by D+Q users are a sign of effectiveness. And that kind of effect is also a common side effect of many anticancer treatments, (when an hopefully effective substance attacks unwanted cells).
I get flu-like symptoms about 12 hours after taking D+Q, but I have no symptoms after taking fisetin. My guess is that D+Q kills more zombie cells than fisetin in my case.
IMHO one day or dose doesn't work well and that's why you see a lot of mixed or non results. Q needs fat to absorb, plan on that. Only a therapy with D kills cancer like growths on your body. That's enough for me to know that Fisetin is not going to give you what you want by itself. Raised moles, some skin lesions and pigmented areas are 'cured' with D in there. That's all the evidence I needed.
My protocol consisted of D&Q Fisetin Met Vit C, no sugar, raised fat diet. Any cell you want to kill dies quicker with a lack of fuel and metformin has synergistic affects in 2 known pathways. The problem She ran into was diarrhea. Bad. I suspect this was the flavonoids and C in someone not used to them and her not adhering to the higher fat diet required to bind to F&Q for absorption. You must eat and this therapy kills appetite. For future I will start Q C and F earlier to get the digestive system used to it. Same goes for Metformin which I believe should be run as high as safely possible. I was very conservative with it at 850/eve 500/morn. The blood sugar affects are immediate but other components linger in the system for many days. For this reason met should be started a week before therapy. It will help with stomach to ramp up dose too.
I tried High dose Fisetin first and felt nothing. It had no effect on my cycling power output or post-ride fatigue. I tried D&Q about 4 months later and had a mild headache (which is rare for me) and no other negative symptoms. Two days after D&Q I did a hard ride and felt strong and felt very low post-ride fatigue. I was not expecting that. Ever since then I've gotten better power numbers and I fell great. I am almost certain it's the D&Q. I don't think fisetin does anything. Poor availability?
Age Reversal Forum
Cell Death Mechanisms Behind D+Q and Fisetin Senolytics