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Glucose level a proxy for sirolimus level?
Some have suggested a blood test is needed to measure rapamycin levels. I wonder if glucose levels can serve as a proxy for sirolimus? my fasting blood sugar is normally in the high 70’s.…
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Life Extension's Bio-Fisetin
I have read that this product is 25% more bioavailable than most other Fisetin products. I spoke with Life Extension and they said for purposes of addressing senolytic cells,…
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Rapamycin dosing 10-30 mg discussion
This was posted on Twitter by @agingdoc1 in an attempt to elevate the discussion around rapamycin ( the thread is here: ). On Twitter, after reading each portion you keep clicking on the content to…
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Need more emphasis on diet
I was disappointed to read through the current age reversal protocol promoted here, and it seems to be focused on expensive "magic pills". There was some mention of calorie restriction,…
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Man stopped aging !!!
Damn ! Even when it happens in front of our eyes doctors are clueless ! https://www.odditycentral.com/news/the-curious-case-of-a-32-year-old-man-who-looks-like-a-14-year-old-boy.…
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Crispr Blindness Patient Outcome?
See https://apnews.com/article/17fcd6ae57d39d06b72ca40fe7cee461. I can find no follow-up on the patient outcome. Have results been published?
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Quercetin recomendations
I have just ordered some Dasatinib using the link in the other thread here. I have started to look to get Quercetin as well and I see many options to order it online.…
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What alternative clinics or strategies should be taken into account for pancreatic cancer Patients ?
Because cancer is directly associated with aging I would like to ask in this forum, what are some of the alternative clinics and treatment strategies I could look into, regarding pancreatic cancer.…
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New Senolytics Targeting ß-Galactosidase
The standard way of identifying senescent cells in vitro is to stain a tissue biopsy with a dye that turns the enzyme ß-galactosidase a dark blue, and then counting the population of blue cells as…
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Quercetin and dihydroquercetin
Hello everyone, I wonder about the differences of these two supplements. I've heard about the toxicity and lower positive effects of quercetin in comparison with dihydroquercetin.…
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Senolytic guru Dr De Keizer says quercetin is useless?
"As for quercetin and dasatinib, I’m absolutely not a fan of those. We’ve tried a couple of experiments; we’ve never seen a good result. Campisi’s lab has tried it extensively,…
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Dr. Sinclair claims he reversed his Horvath clock by 29 years!
Go to 8:45 in this video. Said his biological clock was 60 and he reduced it to 31 by changing his life style. https://www.youtube.com/watch?v=QRt7LjqJ45k&t=8m45s Either he is lying or he is doing…
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Rapamycin nasal spray for the brain?
Has anyone tried snorting rapamycin? intranasal rapamycin reduces oxidative damage in the brain to prevent alzheimers, Parkinson disease and other brain aging disorders.…
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Sirolimus and covid
I take rapamycin (sirolimus) and read as much as I can find. So far I have not heard of anyone taking sirolimus getting covid. Is this significant? Suppression of mtor1 blocks or impedes cell viral…
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Biological Age: Optimal On A Carnivore Diet?
After going on Joe Rogan's podcast, Paul Saladino, MD, posted his show notes, which included his blood test results. Based on that data, is his biological age optimal while on a carnivore diet?…
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NR supplementation does not improve Mitochrondial Function or NAD+ content in Human skeletal muscle after long-term administration.
I'm surprised not commented this study on the usual longevity forums. https://pubmed.ncbi.nlm.nih.gov/31710095/ Abstract Key points: This is the first long-term human clinical trial to report on…
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Source for NR
Hey all, Anyone recommends a source for NR? I used to buy from GeneX Formulas but they're out. I thought they can just online a few of those reaction chambers like they have at the local brewery and…
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DNA methylation test
myDNAge has a $299 urine or blood test for DNA methylation, they're running a buy get one 50% off at the moment. Steve Perry recommends this company, I ordered a test and will let you know how it…
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Exosomes - Experience and Thoughts? QRS?
Hello, There seems to be very little discussion about exosomes here. Is this because of the expense or newness or difficulty in getting them? Has anyone here tried them and could you share your…
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NMN Raw Powder USA ,CANADA,AUSTRALIA Supplier
Why people loves Bontac NMN Raw Powder a lot ! Okay ,there are so many reasons but i will make it short . There are many potential benefits to the body from NMN (Nicotinamide Mononucleotide) —…
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rapamycin, trametinib, lithium combo
This paper: A triple drug combination targeting components of the nutrient-sensing network maximizes longevity https://www.pnas.org/content/116/42/20817 ...…
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DNA Age Testing Kits
Now from EpiAging USA, an Affordable, Authentic, and Non-invasive Biological DNA Age Test. This test will determine your biological age through DNA Methylation and can help you get started on the…
