Rapamycin nasal spray for the brain?

Has anyone tried snorting rapamycin?

intranasal rapamycin reduces oxidative damage in the brain to prevent alzheimers, Parkinson disease and other brain aging disorders.

An increasing number of studies highlight the involvement of aberrant mTOR signaling in the pathogenesis and progression of neurodegenerative disorders, including Alzheimer Disease (AD) [1,2]. Indeed, mTOR pathway has a prominent role in the central nervous system through the regulation of several intracellular processes, such as, protein synthesis, transcription, autophagy, metabolism, and organelle biogenesis [3,4]. These functions are central for the maintenance of brain homeostasis and to regulate the proliferation of neural stem cells, the assembly of circuits, the plasticity of synapses and behavioral aspects like feeding, sleep and circadian rhythms [5,6]. As a consequence, mTOR pathway dysfunction is implicated in different types of brain disorders such as autism, epilepsy, Parkinson disease and AD. Noteworthy, experimental evidences showed that aberrant mTOR signaling is closely associated with the presence of the two key pathological features of AD: senile plaques, composed mainly of fibrillar β-amyloid (Aβ) peptide, and neurofibrillary tangles (NFT), composed of hyperphosphorylated tau protein [1,2,[7], [8], [9]].

https://www.sciencedirect.com/science/article/pii/S2213231718310103