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Is IRON the next anti aging target?
https://www.nature.com/articles/s41467-020-17312-3 Several of the genes we identify have previously been shown to influence lifespan in experiments on model organisms.…
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Slower Biological Aging In People On A Calorie Restricted Diet
https://www.youtube.com/watch?v=vQOTkkCVAJU&t=1s
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Essential Tremor
Are there any studies for treatment of Essential Tremor? Thanks.
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Microbes Affect The Hallmarks Of Aging: Mitochondrial Dysfunction (Part II)
The Hallmarks of Aging are well established, but what is less discussed is the impact of microbes. Viruses, including SARS-CoV-2 and HSV-1 cause mitochondrial dysfunction-more specifically,…
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Epithalon
Anyone inject Epithalon? 1) Any suggestions on both reformulating 50mg Epithalon and daily dose? 2) Anyone have experience mixing in a facial cream? (ALA Mark's rapamycin cream as found all over…
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Quantifying Biological Age With Aging.ai: 24 Blood Tests Since 2009
The maximal reduction for biological age when using the biological age calculator, Phenotypic Age, is ~20 years. In other words, if I'm 80 years old and my biomarkers are all reflective of youth,…
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Questions for Dr. Alan Green
Because there are many persons who are patients of Dr. Alan Green on this forum, please ask him the following questions the next time you see him: 1. Why did you increase your dose of rapamycin from…
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High dose nicotinic acid with acetyl-carnitine restores hair color?
I found out that high dose nicotinic acid (3+ grams) with high dose acetyl-carnitine (1+ grams) seems to be able to at least partially restore hair color in my father in his 70s,…
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Is it me or is Apigenin not so hot in this forum
Treatment of cells with apigenin or quercetin inhibits CD38 and promotes an increase in intracellular NAD+ levels. An increased NAD+ level decreases protein acetylation through sirtuin activation. ..…
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Just joined this site. So I am concerned about how I am aging.
Just joined this site. So I am concerned about how I am aging. I have just recently read about the effects of stress and how it damages your health and leads to premature aging.…
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Ageless Rx trial
https://qalytude.us20.list-manage.com/track/click?u=d0209b3e916e401a53e9c938d&id=983f183e5c&e=636c681f64
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Quantifying Biological Age: Blood Test #6 in 2020
Discussed in the video: What's my biological age on blood test #6 in 2020? What's my average biological age for 2020, and how does it compare with 2019? Are there links between calorie intake,…
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Microbial Products Affect the Hallmarks Of Aging: 1) Mitochondrial Function
The Hallmarks of Aging are well established, but what is less discussed is the impact of microbes and/or microbial products. The bacterial metabolite, LPS, increases during aging,…
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Dogs and cats and people
I am learning something new every day. https://www.purinainstitute.com/can-summit/can-2018/new-insights-into-getting-older This has helped me understand what I read here better.
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Metolazone
Has anyone read this article and have any thoughts? Are there any of drugs that do anything similar that have been discussed? Thanks https://www.osaka-cu.ac.…
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ISRIB Reverses Age-Related Mental Decline
https://elifesciences.org/articles/62048 Thoughts on this?
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DHEA and Sperm
Hi all, I am posting on behalf of my husband who has been part of a clinical trial in order to boost his fertility. Other than low dose naltrexone, he has been put on a daily dose of 50 mg of DHEA…
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Neutrophils, Lymphocytes, Monocytes: What’s Optimal For Health And Longevity?
For those who track their WBC differentials, here's my latest video about what's optimal for neutrophils, lymphocytes, and monocytes in terms of health and longevity: https://www.youtube.…
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Can any meaningful conclusions of efficacy/harm ever be drawn form individual experience/"self experimentation"?
Hi. This post might irritate, but I mean well. It's prompted by a useful article I read this morning...about the nocebo effect with statin's. https://www.nejm.org/doi/full/10.…
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How much autophagy with rapamycin
How many hours or days do you think are in autophagy when taking weekly rapamycin? Just based on half lives, do you think it is 2 days or is it much longer?
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Finished the First 3 Protocol Steps
I an 72 and have been taking metformin (twice a day but recently increased to 3 times a day) for 5 years. I recently completed 6 patches of NAD+. I also have just taken 2 doses of quercetin and…
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Adverse Reaction to Nad+ Patches
I have used 4 patches so far. The first was on my lower back just above sacrum. Second was right below my knee. Third and fourth were on my right and left flanks.…
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HDL: What's Optimal For Minimizing Disease Risk And Maximizing Longevity?
Meta-analysis for the association between HDL with all-cause mortality risk has identified HDL levels 55 - 60 mg/dL range as optimal. However, that data includes subjects up to 85y-in the video,…
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Tracking progress of my experiment
Hi everyone, I wanted to try a self experiment to see if diet and exercise had an effect on my biological age. It has been a while and I wanted to check my progress,…
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Inexexpensive Rapamycin and Datatinib from India
Just received my shipment of 200 1mg rapamycin pills and 120 20 mg datsatinib pills from Varun Medicals at https://www.varunmedicals.com. The rapa pills were from Swiss Garnier Biotech marketed…