Anyone taking Berberine supplement as an AMPK activator? Seems to have some literature documenting its use.
I have used AMPK activator (life extension) one pill per day for two months and then I have used Berberine 500 mg once or twice a day (thorne product) for two months. Now I am back on AMPK activator.
I have good experiences of both products. They both reduce fat and weight. One difference is that when taking berberine I often felt really hungry. ( I do intermittent fasting as well. Using a protocol with 14- 16 hour daily fasting, 6 days a week or so).
When I take AMPK activator I don’t get the same kind of foodcrawings.
Both products reduced my waistline as well as my wieght. I have a feeling that beberine might have been more efficient at reducing the fat content in my body. Especially the subcutaneous fat deposit. When on gynnostemma I have made a personal observation that it reduced intraabdominal fat more than the subcutaneous fat. My waistline shrunk when on AMPK activator but the subcutaneous fat did not change as much as it did when I changed to Berberine.
Now when I am back on AMPK activator I seem to have accumulated a tiny bit more subcutaneous fat on my waistline but weight is about the same. Maybe half kilo up. After two month on AMPK activator and two months on berberine I lost 4,5 – 5 kg. from 77,5 to 72,5 kg. This together with intermittent fasting.
These are my very personal observations and experiences. My plan is to repeat the program. Now I am on two months AMPK activator and then two more months on berberine.
Karl i take both Metformin and berberine. Check out this study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059038/ and there other as well. They are actually complimentary. Also idea is to not over do it when you take them together.
Karl both berberine and Metformin can be considered diabetic medicines as they have similar good efficacy. Just because you can buy berberine otc in the us doesn’t make it any less effective for blood sugar control. Also if you don’t care about lipids than Metformin would be a better choice as you know what you are taking as it is per prescription and production is fda monitored; and it does nothing for the lipids, which you said you don’t care about. Only Berberine has good ldl-c and triglyceride lowering effect. Both Metformin and berberine activate ampk equally well. The idea is that when you combine both you still get ampk activation plus they cancel each other negative effects with berberine being more dangerous in the higher doses. Because of that when you take berberine you need to cycle it on and off.
Anyone taking this improved bioavailability Berberine, dhBBR? Appears to be FAR superior to regular berberine for lipids/glucose/anti-aging?
Only looking to add it as an anti-aging intervention, no glucose/lipid issues.
I have added 4 mg/weekly Rapamycin...looking to additional low risk/high reward additions.
Here is a link to one supplement vendor for dhBBR:
Berberine derivatives reduce atherosclerotic plaque size and vulnerability in apoE−/− mice
Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I
Berberine suppresses gero‐conversion from cell cycle arrest to senescence
Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression