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Re: Glucosamine instead of Metformin and Rapamycin? @MAC without Metformin and berberine my a1c is 5.3 with Metformin and berberine after 6 months and longer, it is 5.1 - 5.2, Ldl without berberine is about 180 and after six month on berberine it is…
- Joe smith
- Joe_smith
- 3 yrs ago
- AMPK Activation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin? @MAC no real change in my bio markers. A1c always around 5.2, hdl about 80, triglycerides 100 and ldl about 130. To address urine ph I take potassium citrate now foods supplement and eat lemons.
- Joe smith
- Joe_smith
- 3 yrs ago
- AMPK Activation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin? @MAC Metformin and rapamycin is doctor prescribed. Berberine is really on my own that said I fully disclose to my doc what I’m doing and hasn’t heard any objections or concerns yet.…
- Joe smith
- Joe_smith
- 3 yrs ago
- AMPK Activation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin? @Paul Beauchemin I will review the article, I know it mentions 42 female mice of particular strain. At best this is enough to form a preliminary null hypothesis.…
- Joe smith
- Joe_smith
- 3 yrs ago
- AMPK Activation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin? @Paul Beauchemin well according to the research I reviewed it should impact resistance training in mice by 50 %. Anyway I wish Dr Green publish some studies to give us more insights here.
- Joe smith
- Joe_smith
- 3 yrs ago
- AMPK Activation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin? @MAC well yes rapamycin is micro-glide but the paper focused on antibiotics and it doesn’t appear to mention rapamycin. I think it would be a stretch to think that it covers it too.…
- Joe smith
- Joe_smith
- 3 yrs ago
- AMPK Activation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin? @Stevan Lieberman both berberine and Metformin are organic compounds but derived from different plants. Hence different mechanism of action. Berberine also lowers ldl-c and triglycerides,…
- Joe smith
- Joe_smith
- 3 yrs ago
- AMPK Activation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin? @Stevan Lieberman I’m 6 foot tall and about 160 pounds, thin and muscular. I exercise 5 times a week. I can do a single leg sit to stand. I’m about 5 years older than you are.…
- Joe smith
- Joe_smith
- 3 yrs ago
- AMPK Activation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin? @Stevan Lieberman I’m glad that rapamycin is working for you. How much and how often are you taking? Also what brand and where are you getting it from?…
- Joe smith
- Joe_smith
- 3 yrs ago
- AMPK Activation
- Reported - view
Re: Hair regrowth @samantha scott So are you saying that the hair treatment described in the article: combination of the hair transplant followed by PRP+ acell is the way to go?
- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- General Discussion
- Reported - view
Re: Treatment for Reducing Arterial Plaque and Imflammatory Cells: @BobM that’s extensive supplement stack. Have you tried magnesium for plaque reduction? Also do you have wbc test before you started taking rapamycin?
- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- General Discussion
- Reported - view
Re: I recently started Metformin for IR, but am having a lot of gut issues,even after 2 weeks . Thoughts about other possible supplements? @Andrew P K Yap makes sense. Also the dose as low as 250mg per day is most likely sufficient.
- Joe smith
- Joe_smith
- 4 yrs ago
- General Discussion
- Reported - view
Re: Fisetin to Clear Senescent Cells @BobM Please see my other post recent post on the subject. I'd advise that you reach out to Tom Dayspring ASAP. You need solid cardiologist (i'm not) with experience and wisdom to guide you and not…
- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Paul Beauchemin Hey Paul, I'm basing it on guidance opinion of of American College of Cardiology supported by substantial meta study: https://www.acc.…
- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Van Isn't that scary about even children and young men having plaque build up? I blame it on our misguided dietary guidelines that got perverted by the processed food industry and lead us to…
- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Fairy8i8 Indeed great to see formal study planned but lets' wait for the safety outcome before we start everybody on senolytics. OK? Now I don't doubt that senolytics remove senescent cells.…
- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Van i’m not disagreeing with what you just have Just replied with. And yes the most prudent approach would be to reduce inflammation and especially so in cases like diabetes when dealing with…
- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Van This video from Dr Brewer is about CIMT testing and plaque/calcium in the arteries and not on the treatment and whether statins OVERALL reduce mortality risk. And yes, I respect Dr.…
- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Paul Beauchemin Well, temporary spike in the cholesterol happened in the case you brought up. Basically, young transplant patient tried to kill herself.…
- Joe smith
- Joe_smith
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells Good point about statins and longevity. Statins work in just a small subset of people with specific type of ldl and then not very well. Basically if your ldl is of smaller type you need something,…
- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) @Andrew Whitfield potentially not safe due to interaction with the meds you already taking. Please see the following article. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703353/
- Joe smith
- Joe_smith
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin to Clear Senescent Cells @Fairy8i8 Well I have quercetin and Fisetin in the fridge. But I'm not taking them now. I'm taking prescribed low-dose Rapa for anti-aging and I'm concerned about interactions.…
- Joe smith
- Joe_smith
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Fairy8i8 Yes, this thread is titled fisetin to clear senescent cells, but we are really talking here about at least 3 key senolytics: Fisetein, Azithromycin, and Dasatinib. And some others too.…
- Joe smith
- Joe_smith
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Fairy8i8 NAM is good and as you pointed out it has a solid research support behind it. It is meant to reduce irritation. In your dry climate I'd combine it with triglycerides for good skin barrier.…
- Joe smith
- Joe_smith
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Fred Cloud I don't feel. (well sometimes I do 🙂.) I'm only interested in the scientific proof, research and reason . Check this out Senescent cell turnover slows with age providing an explanation…
- Joe smith
- Joe_smith
- 4 yrs ago
- Self-Experimentation
- Reported - view

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Joe smith

Joe_smith

SF Bay Area

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Joined: 08 Apr 2020

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