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Re: Fisetin to Clear Senescent Cells @Van interesting stuff. The doses by themselves seem moderate. That said together it seems a lot. I take 2mg rapamycin from Walmart once a week. Rapamycin by itself has quite an effect on me.…
- Joe smith
- Joe_smith
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Fairy8i8 1) Nuchido is quite interesting as the company is built around more modern concept important to the point I’m trying to convey here but clearly failing i.e.…
- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Fairy8i8 Looking at some studies technically it is a rate of clearing senescent cells that decreases with aging and slows down 5x. So, our immune system leaves senescent cell around for much longer…
- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells It would be great to share before and after blood test like @JGC did. Especially so medium and long term tests to see the progress.
- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @JGC Do you have updated test results you could share?
- Joe smith
- Joe_smith
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Karl Voice of reason! I think the best approach is to mimick for now Walter's Longo's fasting protocol translating it to senolytics on how often depending on your personal physical shape.…
- Joe smith
- Joe_smith
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Staffan Olsson Very useful piece of information. I think we should put more precision and engineering approach to the supplementation if we ever want to achieve repeatable and predictable results.…
- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Fairy8i8 It sounds like we came to similar realization with respect of supplements and their interactions. They can be very useful but you need to be very cautious and conservative while applying…
- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Fairy8i8 You make two interesting points : 1) The more sometimes is not more effective 2) Interaction with the other supplements/drugs. I think both of these have to do with the fact that we are…
- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Fairy8i8 Hi, see my follow up below. Basically the tests were done by Dr Jed Fahey lab at John Hopkins, #1 authority on the subject in the world. I didn't dig deeper into how they test and under…
- Joe smith
- Joe_smith
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @David H Dr Brad Stanfield (New Zealand) is great and I follow him as well. My comment to him was the same as on this thread. You just can't read ingredient list and believe manufacturer.…
- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @David H You are good at research 🙂 . Net net when you can get Avmacol for $24.95 for 60 capsules off Nutramax website and Broccomax on iherb for $18.…
- Joe smith
- Joe_smith
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Fairy8i8 Per Dr Rhonda Patrick Broccomax is pretty much useless. When tested it doesn't contain at all what its labels claims; Throne contains 10% claimed amounts and Avmacol 40%.
- Joe smith
- Joe_smith
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Levels of senescent cells correlates with death? If the article is right then the rate of clearing of the senescent cells deteriorates with age. Hence, the best solution would be to increase that rate of clearing on continuous basis and no through…
- Joe smith
- Joe_smith
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: NAD+ Patches @Rudi Hoffman so what have you observed taking Deprenyl?
- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- NAD+ Restoration
- Reported - view
Re: Introduction to Young Plasma Infusions @JGC if you go https://twc-stanford.shinyapps.io/aging_plasma_proteome/ you can enter a gene/protein in the blood and see level of changes with aging. There is about 2925 proteins associated with…
- Joe smith
- Joe_smith
- 4 yrs ago
- Young Plasma Infusions
- Reported - view
Re: Senolytics @Edward Meininger My concern with the senolitics is that big-time researchers like Judith Campisi and Dimitry Bulavin clearly state and demonstrate through their research that senolitics don’t…
- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Berberine @Zisos Katsiapis also low magnesium is an issue with Metformin. Check out this study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760872/ and this is also so in real life.…
- Joe smith
- Joe_smith
- 4 yrs ago
- AMPK Activation
- Reported - view
Re: Dasatinib @Rob8311 very impressive results for Boston terriers life extension. So when did you start them on it and was specific type of rapamycin was it?
- Joe smith
- Joe_smith
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Introduction to Young Plasma Infusions @JGC yeah tet proteins are actually very large ~180-230-kDa. What I was trying to say is that high 5hmC in young blood restores tet2, which in turn binds to dna and demethylates.…
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- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- Young Plasma Infusions
- Reported - view
Re: Senolytics @Edward Meininger please stop what you doing and see doctor ASAP!
- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Introduction to Young Plasma Infusions @JGC sounds good. I’d be shocked if they didn’t. Further I suspect that they are the protagonists.
- Joe smith
- Joe_smith
- 4 yrs ago
- Young Plasma Infusions
- Reported - view
Re: Introduction to Young Plasma Infusions @JGC There is a paper that explains tet enzymes role and the fact that dna demethylation occurs in a cyclical manner. Young plasma has tet enzymes and old one has less.…
- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- Young Plasma Infusions
- Reported - view
Re: Introduction to Young Plasma Infusions @JGC tet2 enzyme in young plasma? I guess we will have to wait patiently for more info.
- Joe smith
- Joe_smith
- 4 yrs ago
- Young Plasma Infusions
- Reported - view
Re: Sources of dasatinib @Andrew P K Yap http://www.anti-agingfirewalls.com/2018/09/02/aging-cell-and-tissue-repair-renewal-and-regeneration-inflammation-and-the-sasp/
- Joe smith
- Joe_smith
- 4 yrs ago
- 1
- Senolytics Discussion
- Reported - view

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Joe smith

Joe_smith

SF Bay Area

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Joined: Wed Apr 08 05:30:51 UTC 2020

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