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Re: TRIIM study results are in I am actually quite confused with all those clocks. Very difficult to interpret, and no relationship with each other. Here are some values: Calendar Age: 70 myDnage : 75 epiAge : 66.…
- Zisos Katsiapis
- Zisos_Katsiapis
- 1 yr ago
- Thymus Regeneration
- Reported - view
Re: Recent Plasma-Replacement Results @JGC I agree with that. It was mentioned before, so I did not want to repeat. However, controlling for Albumin is also necessary, to insure that it is not Albumin that causes the "benefits".…
- Zisos Katsiapis
- Zisos_Katsiapis
- 2 yrs ago
- Young Plasma Infusions
- Reported - view
Re: TRIIM study results are in @Jim N Very good point ! And very easy to check, actually.
- Zisos Katsiapis
- Zisos_Katsiapis
- 2 yrs ago
- Thymus Regeneration
- Reported - view
Re: Recent Plasma-Replacement Results @ staffan_olsson The Conboys replaced old plasma with saline at 5% Albumin. They concluded that it was the removal of plasma that was responible for the effect.…
- Zisos Katsiapis
- Zisos_Katsiapis
- 2 yrs ago
- 1
- Young Plasma Infusions
- Reported - view
Re: young.ai I wanted to compare two senolytic approaches: a) Fisetin: 1500mg/ day for two days. Repeat after 30 days. b) Dasatinib / Quercetin one dose of 200mg D / 2000mg Q. Repeat in One week.…
- Zisos Katsiapis
- Zisos_Katsiapis
- 2 yrs ago
- 1
- Assessing Biological Age
- Reported - view
Re: Fisetin to Clear Senescent Cells @JGC I notice that JGC's October testing: DNAm Age 8 years lower than Calendar Age Aging.Ai 30 years lower than Calendar Age I have also recently done similar testing. I am now 69 My DNAm Age: 61 (I.…
- Zisos Katsiapis
- Zisos_Katsiapis
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Berberine @David H Your suggestion definitely makes sense. I thought about it some times. And I might do it in the future. The basic reason I avoided until now, is this: I have a "B12 deficiency gene" (MTHFR),…
- Zisos Katsiapis
- Zisos_Katsiapis
- 3 yrs ago
- AMPK Activation
- Reported - view
Re: Berberine @Joe smith There is one more disadvantage of metformin. It lowers vitamin B levels. In fact, I take berberine instead of metformin for that specific reason.…
- Zisos Katsiapis
- Zisos_Katsiapis
- 3 yrs ago
- AMPK Activation
- Reported - view
Re: Restore NAD+ Level without NR or NMN @Henry walker Hm... I guess we do need to be careful. I wish there was an easy way to measure CD38 and NAD+. Then we could adjust utilization of supplements to calibrate for the appropriate levels.…
- Zisos Katsiapis
- Zisos_Katsiapis
- 3 yrs ago
- NAD+ Restoration
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin? @Joe smith Thank you for info. I take Rapamycin and others w/o prescription. So, no doctor to ask. But Allan Green usually prescribes 5mg / week or less.…
- Zisos Katsiapis
- Zisos_Katsiapis
- 3 yrs ago
- AMPK Activation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin? @Joe smith Thank you for info. In fact, I currently take Berberine, and every now and then Rapamycin. But I am trying to figure out if I should change. I am a bit scared of Rapamycin. Dr.…
- Zisos Katsiapis
- Zisos_Katsiapis
- 3 yrs ago
- AMPK Activation
- Reported - view
Glucosamine instead of Metformin and Rapamycin?
I happened to read a very old blog by Vince Giuliano regarding Glucosamine http://www.anti-agingfirewalls.com/2014/06/09/glucosamine-for-longevity/ In it he gives sufficient evidence that…
- Zisos Katsiapis
- Zisos_Katsiapis
- 3 yrs ago
- 45 replies
- 1,050
- 1
- AMPK Activation
Re: Restore NAD+ Level without NR or NMN @Joe smith I was not aware that "too much" NAD+ increases cancer risk. So this is one more thing to worry about. I would assume that this is a function of age.…
- Zisos Katsiapis
- Zisos_Katsiapis
- 3 yrs ago
- 1
- NAD+ Restoration
- Reported - view
Re: Restore NAD+ Level without NR or NMN @Zisos Katsiapis Have done some further reading, and realized that Niacinamide might not be a good choice, because in large doses it inhibits sirtuins. So, I will stick to sublingual NMN for now.
- Zisos Katsiapis
- Zisos_Katsiapis
- 3 yrs ago
- 2
- NAD+ Restoration
- Reported - view
Re: Restore NAD+ Level without NR or NMN @Joe smith Very interesting. So it is possible to boost NAD+ substantially at a very low cost. Example: Supplement with Apigening (or consume substantial amount of parsley) Supplement with EGCG (or…
- Zisos Katsiapis
- Zisos_Katsiapis
- 3 yrs ago
- 2
- NAD+ Restoration
- Reported - view
Re: Restore NAD+ Level without NR or NMN @Joe smith Wow! That is truly amazing. In fact, I have been supplementing with NMN and 50mg Apigenin (also consuming lots of Parsley). I expected some synergy,…
- Zisos Katsiapis
- Zisos_Katsiapis
- 3 yrs ago
- 1
- NAD+ Restoration
- Reported - view
Re: Restore NAD+ Level without NR or NMN @Larry Having read the content of the link you provided, I noticed that they also suggest that the "CD38 expression is believed to be the key modulator of lowered NAD+ levels with aging".…
- Zisos Katsiapis
- Zisos_Katsiapis
- 3 yrs ago
- 1
- NAD+ Restoration
- Reported - view
Re: Restore NAD+ Level without NR or NMN @Larry Here I am not trying to compare boosting NAD+ with other interventions. Instead, for those that are interested in boosting NAD+, we suggest that there might be an alternative to supplementing…
- Zisos Katsiapis
- Zisos_Katsiapis
- 3 yrs ago
- 1
- NAD+ Restoration
- Reported - view
Restore NAD+ Level without NR or NMN
To keep NAD+ levels high, almost everywhere I look, it is suggested that we must supply precursors (NR or NMN), so that we can induce "production" of NAD+. Both NR & NMN are not cheap.…
- Zisos Katsiapis
- Zisos_Katsiapis
- 3 yrs ago
- 15 replies
- 813
- 2
- NAD+ Restoration
Re: Rapamycin retards epigenetic ageing A study by Maria Blasco shows that the effect of Rapamycin on mice with long telomeres is positive (Adds to healthspan), but negative for mice with short telomeres.…
- Zisos Katsiapis
- Zisos_Katsiapis
- 3 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age @albedo This makes a lot of sense. Your interpretation of "Ptypic Age" and "DNAm Phenoage" clears my confusion. I had assumed that "Ptypic Age" and "DNAm Phenoage" should be interpreted as a proxy…
- Zisos Katsiapis
- Zisos_Katsiapis
- 3 yrs ago
- Assessing Biological Age
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age @JGC Thank you for clarification. Maybe a note should be made in the excel sheet that calculations of "Ptypic Age" and "DNAm Phenoage" are valid only for t=10 years
- Zisos Katsiapis
- Zisos_Katsiapis
- 3 yrs ago
- Assessing Biological Age
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age @albedo Going into the details of the calculation does not really help me. I can see the calculations. But intuitively it does not make sense to me. As I understand it,…
- Zisos Katsiapis
- Zisos_Katsiapis
- 3 yrs ago
- Assessing Biological Age
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age @JGC Thank you for your responce. Yes, I have noticed it. And it is reasonable that as I change "t" from 10 years to 20 years, the probability that I will die will increase.…
- Zisos Katsiapis
- Zisos_Katsiapis
- 3 yrs ago
- Assessing Biological Age
- Reported - view
Re: New blood tests can reveal your life expectancy @JGC When you actually change 10 years to 20 years, you get a higher mortality. However, at the same time the phenoage changes when you plug 20 in place of 10. This does not make sense to me.…
- Zisos Katsiapis
- Zisos_Katsiapis
- 3 yrs ago
- Assessing Biological Age
- Reported - view

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