Dasatinib

JGC did you order from bonhoa.com and what did you think of the quality of their product. Some are concerned that the quality of meds from overseas may not be a good quality as domestic products. Others believe that Big Pharma jacks up the prices of drugs that should not be as high as we see here in the States. I'm of the latter group.

I just came across the bonhoa site today and see that their prices are about 10% of what pharmacies charge in the USA. Have you tried the US meds vs the overseas meds?

Wuwei57 I ordered Lucidas (SPRYCEL) Dasatinib 70mg from bonahoa.com . The reason for the low price is explain here:
https://en.wikipedia.org/wiki/Dasatinib#Cost
I statred taking the dasatinib + qurcertin three months ago, and my osteoarthritis has been improved drastically, so I think there is no problem in the quality.

Peter5.0 

I did purchase a bottle of Lucidas Pharmaceuticals brand 60 Dasatinib 50 mg tablets from BonHoa for a bit over $200.  I have no way of evaluating the quality as compared to the Bristol-Meyers-Squibb product ($2k for 4 pills), which I have not tried.  However, others have made the same purchase of Dasatinib and reported that they observed senolytic results.

JGC thanks, the speaker we listened to on Sat recommended buying US products only because of FDA supervision in the manufacturing process. Personally, I believe that US drug makers really jack up prices to boost profits, as we have seen with Epipens and many other drugs that have seen huge markups in the past few years. Maybe other studies will compare the quality of the two products. I just wanted to hear about first hand accounts of those who have purchase from bonhoa with no complaints on quality. We do know one man in Vegas who was part of a trial and probably took the $2000 tabs from Bristol Meyers. He may be willing to try out this other version and give feedback in its strengths and quality. 

Even if its only 90% as effective as the bonhoa caps, I'm willing to go with that to save $1750. 

Peter5.0 If that speaker who recommended US products only couldn't even accept Canadian products, then it was just FUD favoring US distribution and FDA jurisdiction.  The primary reason to buy foreign is because of the barriers set up by the FDA.  If I had to pay $2000 for dasatinib, then I just would do without.  At $200 I'm game.  And the Indian pharmacy delivered a product that looks and acts exactly like what has been described for dasatinib.

RobH he didn't specifically exclude Canadian drugs but had experience with the FDA supervision of drugs produced in the USA. He felt that we would get the highest quality due to the monitoring by the FDA during the production. We did not get into the discussion of price gouging by US pharmaceutical companies. Do you have access to Canadian sources and know their prices? I have a few contacts in Canada too. 

Peter5.0 I think Dr. Green, a US doctor, recommends a Canadian pharmacy for rapamycin.  It was like 30% or so cheaper than the US version, and acceptable quality.  It may even be the same manufacturing plant with a "destined for Canada" box - I don't really have the details.  But the essential point is that acceptable quality rapamycin is available at significantly lower price for those willing to jump the hoops enforced by FDA.  While I purchased my first batch of rapamycin from India, it turns out that it is available even cheaper from IAS in Britain.  IAS is a high end offshore pharmacy that has been in business for decades, no thanks to the FDA.

Canada has such a high reputation for drug quality that they have become a brand name to feature, even when the actual pharmacies have no connection to Canada.  If a "Canadian" pharmacy doesn't require a prescription, then it's not in Canada.  I would avoid any such place as their ethics are obviously on the suspect side.  The Indian pharmacies I've used are proud of their businesses, and haven't hidden under false pretenses.

The use of a permission slip (prescription) from a doctor is not a universal practice in the world.  Mexico in particular allows a pharmacist to sell most drugs on their own authority.  As far as I can tell, Mexico does not have a problem with what we call prescription drugs.  Illegal drugs, yes.  Everyday drugs that doctors recommend are not a problem worth creating the US style bureaucracy.

RobH can you post a link to IAS so I can check it out? 

Peter5.0 

Here's what the Wikipedia article on Dasatinib has to say about Bristol-Meyers Squibb pricing:

"The Union for Affordable Cancer Treatment objected to the price of dasatinib, in a letter to the U.S. trade representative. The average wholesale price in the U.S. is $367 per day, twice the price in other high income countries. The price in India, where the average annual per capita income is $1,570, and where most people pay out of pocket, is Rs6627 ($108) a day. Indian manufacturers offered to supply generic versions for $4 a day, but, under pressure from the U.S., the Indian Department of Industrial Policy and Promotion refused to issue a compulsory license.[4]

Bristol-Myers Squibb justified the high prices of cancer drugs with the high R&D costs, but the Union of Affordable Cancer Treatment said that most of the R&D costs came from the U.S. government, including National Institutes of Health funded research and clinical trials, and a 50% tax credit. In England and Wales, the National Institute for Health and Care Excellence recommended against dasatinib because of the high cost-benefit ratio.[4]

The Union for Affordable Cancer Treatment said that "the dasatinib dispute illustrates the shortcomings of US trade policy and its impact on cancer patients"[4]"

Peter5.0 Just another pointer back to the thread on IAS - https://forum.age-reversal.net/t/80rgtz

JGC 

Did Bon Hoa require a prescription from you, and if so how did you get on for this off label use?

JGC Any particular reason to take dasatinib on an empty stomach?

Rob8311 

No particular reason for the empty stomach except timing.  Last year we took a BioPerine cap at 9 AM followed by the D+Q session at 10 AM.  We usually have a light breakfast anyhow.  Some people claim that it's better to do D+Q with a high-fat meal.

JGC That's good, because the drug sheet says it's fine with or without food.  One less substance to agonize about when to take, and good for those with sensitive stomachs.

Dan Nave 

Bon Hoa did ask me for a prescription, but they shipped after I told them that the Dasatinib was to be used to treat my aging Shetland Sheepdogs (true, but incomplete).  However, I believe that others have obtained Lucidias Dasatinib from them without a prescription.

JGC My guess is that using a credit card to pay for what are prescription drugs in the US triggers the prescription request. Ditto bank based payments, although I've had success with eCheck. RIA money seems OK.

RobH 

I paid them with PayPal, and for some reason they did not require payment until the shipment was delivered.

Peter5.0 

RobH Great reporting Rob! Thanks! I'll likely follow your lead in the near future!

RobH   Can you take this combo while also taking Rapamycin? Thanks for any help you can offer.