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Two interesting articles related to epigenetics

These are two interesting articles I found one from the other This one https://www.mdpi.com/2073-4409/11/3/468/htm Has a detailed look at the links between epigenetics and ageing.…
- John_Hemming
- 3 yrs ago
- 44
- General Discussion
Re: Stopping Metformin
@Karl That's a good idea. I have a few more days left on this session. I am going to try a hack to extend the session beyond 10 days, but otherwise I am intending to end the CGM at the end of this…
- John_Hemming
- 3 yrs ago
- AMPK Activation
- Reported - view
Re: Tracking supplement/med use
I keep a daily text note of what I am doing. I have a weekly routine for supplements with different groups of supplements. I also record weight, blood pressure and all the fitbit sense recordings.…
- John_Hemming
- 3 yrs ago
- General Discussion
- Reported - view
Re: Stopping Metformin
I am not sure about the analysis in the recent report on Metformin. I have been taking Berberine. I have not noticed any effect. Recently I implanted a Continuous Glucose Monitor.…
- John_Hemming
- 3 yrs ago
- AMPK Activation
- Reported - view
Correlation between Hearing Loss and EpiGenetic Age

This is an interesting paper: https://www.frontier...021.790926/full "Discussion: The present study suggests that some epigenetic age acceleration measurements are associated with hearing.…
- John_Hemming
- 3 yrs ago
- 3replies
- 134
- Assessing Biological Age
Re: New Book titled Rapamycin, mTOR, Autophagy & Treating mTOR Syndrome
Why should anyone buy the book?
- John_Hemming
- 3 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: HBOT and Rapamycin protocol
@John Hemming I have looked at this issue a bit further as my protocol involves considerable amounts of melatonin. As far as I can tell the concentrations of melatonin need to inhibit HIF are much…
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: HBOT and Rapamycin protocol
@Bart Balder I have recently found out that serum Metatonin tends to inhibit HIF in some circumstances, but that is more of a timing issue than anything else.…
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@Dan Nave I don't think Natto produces MK4, however. Obviously Natto has other things in it, but as far as the menaquinones go I think only mk7 comes from natto.…
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: EpiAge test results
@Paul Beauchemin Having looked at this a bit further it appears that saliva based tests pick up primarily the epigenetic strucuture of white blood cells.…
- John_Hemming
- 3 yrs ago
- Test Results Discussions
- Reported - view
EpiAge test results

I thought I would try out one of the online services that claim to offer EpiGenetic age testing. I picked this one https://epi-age.com/ Which is this company HKG Epitherapeutics - Hong Kong Unit 119,…
- John_Hemming
- 3 yrs ago
- 2replies
- 128
- Test Results Discussions
Fisetin and Sleep

I am trying to find out more about the interplay between Fisetin and sleep. I noted there is another thread that looks more widely at Fisetin in which some sleep problems are mentioned.…
- John_Hemming
- 3 yrs ago
- 12replies
- 752
- 1
- Self-Experimentation
Re: Anyone actually experience marked increased energy from NMN?
@Dan Nave Only Mk7 comes from Natto. It is possible to supplement with MK4 and mk9 as well. Certain foods mainly hard cheese also have the longer chains of isoprenes, but that varies quite bit.…
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@Jared Hair is I think a particularly complex aspect of the body that is an indicator of health. That is why I think high frequency hearing loss tests are a good test for general health (and very…
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@Jared A lot of body systems benefit from the availability of a number of molecules. For example bones need vitamins D3 and K2 (mk4 and mk7) for handling calcium as well as melatonin to get the…
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@Jared It was not that many hairs, but it is a gradual process that does not appear to have halted yet. My own hypothesis is that this arises probably at least in part from a demethylation process.
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@JGC You are right in that receptors can get washed out. However, Melatonin also acts in ways other than a hormone. For sleep it emphasises the effect of GABA.
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@Paul Beauchemin you could try resveratrol, but that might also cause bleeding.
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@Paul Beauchemin I also did a video about sleep hacks in which I talk about using Cox-1 inhibitors say about 1-2 hours before the CAR to minimise it or after it has happened to try to get back to…
- John_Hemming
- 3 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@Michael Thanks for that I only do videos where I think I have something to add to the debate rather than just a repetition of what someone else has said.
- John_Hemming
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Senescent Cells - an interesting video

I thought this was quite an interesting video.
- John_Hemming
- 3 yrs ago
- 43
- General Discussion
Re: Anyone actually experience marked increased energy from NMN?
@RobH Without checking the research from memory I think there are a number of cognitive benefits from good sleep. Which of those are really melatonin and which not affected is hard to determine.
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@Paul Beauchemin There is a difficulty in that the side effects are difficult to spot as they occur gradually. There is quite a bit of research, however, that justifies them.…
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@JGC Without going into the question of how you come to your conclusion. I can say experimentally it is not true. However, it will vary from person to person.
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@JGC The reason I take large amounts of melatonin is that I like the side effects. I did a video about Melatonin https://www.youtube.com/watch?v=tfEJcUDVUoo&t=153s It is the case, however,…
- John_Hemming
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view

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