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Re: Anyone actually experience marked increased energy from NMN?
@Michael no the timing is key to this. My priority is good sleep, but i also take more for the side effects. I dont think taking it before sleep is helpful.…
- John_Hemming
- 3 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@Michael melatonin has a wide range of effects. Some are immediate and some happen over a longer period. The time it is taken is critically important as to the effect.…
- John_Hemming
- 3 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Molecular Hydrogen
I have decided to go for the h2Genesis machine.
- John_Hemming
- 3 yrs ago
- General Discussion
- Reported - view
Re: https://age-stop101.myshopify.com/
I wonder what research evidence there is to justify any of your proposed interventions? I am probably not the only person who is interested in that sort of thing.
- John_Hemming
- 3 yrs ago
- 1
- General Discussion
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@Michael The amount I take each night (it is almost invariably after midnight and before 8am) varies from 0 through to over 400mg. Melatonin is a circadian hormone and it is important not to…
- John_Hemming
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Molecular Hydrogen

I have been looking at the research on this and it appears to have some anti-inflammatory potential. I am wondering what experience people have with it.…
- John_Hemming
- 3 yrs ago
- 1reply
- 52
- General Discussion
Re: Anyone actually experience marked increased energy from NMN?
I have particularly tested Melatonin on Gingivitis. I often take it sublingually and the days I don't take it my gums are more inflamed. My dental hygienist was really impressed by the changes…
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
My personal experience inclines me to the view that Melatonin assists in reducing inflammation.
- John_Hemming
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
Initially I bought NMN Max which according to tests has no NMN in it. Now I am taking some real NMN I have noticed a bit of an ache in my muscles that I think links to it,…
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Berberine and Melatonin - can this reverse aging of cells?
And another sleep video https://www.youtube.com/watch?v=WJ3edPRo4ic
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: HBOT and Rapamycin protocol
I am using an Oxygen concentrator for HIF although I will try mild hyperbarics. I am not persuaded that adding the exercise makes that much of a difference.…
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Are members here having real results with rapamycin?
@T F Thanks for that. Obviously different people have different protocols for improving their cellular health. It may be that Rapamycin is part of this,…
- John_Hemming
- 3 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Are members here having real results with rapamycin?
@John Hemming I heard something from Sandra Kaufmann expressing some concerns about Rapamycin and I think I have found the research. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.…
- John_Hemming
- 3 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Are members here having real results with rapamycin?
@Paul Beauchemin Thank you for this. Much that I think measures of things like methylation are helpful there is an argument to concentrate on more easily observible things.…
- John_Hemming
- 3 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Are members here having real results with rapamycin?
@Paul Beauchemin Thank you for this. To me what is curious about the question as to what improves cellular health is how to measure it. Human beings often measure aging by how people look.…
- John_Hemming
- 3 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Are members here having real results with rapamycin?
@Paul Beauchemin What do the blood tests report on?
- John_Hemming
- 3 yrs ago
- Rapamycin Discussion
- Reported - view
Re: The potential of comparative results based upon home testing
here's another https://www.telegraph.co.uk/wellbeing/future-health/brain-age-test/
- John_Hemming
- 3 yrs ago
- Assessing Biological Age
- Reported - view
Re: An interesting presentation.
@Paul Beauchemin She refers at the end to this paper which I had not read before https://www.sciencedirect.com/science/article/pii/S1568163721000143 I think to summarise that as a rule too long a…
- John_Hemming
- 3 yrs ago
- General Discussion
- Reported - view
Re: The potential of comparative results based upon home testing
Here's another one https://www.westlakedermatology.com/blog/pinch-test-for-skin-elasticity/ SKIN ELASTICITY TEST INSTRUCTIONS With your hand relaxed and facing palm down,…
- John_Hemming
- 3 yrs ago
- Assessing Biological Age
- Reported - view
Re: An interesting presentation.
@Paul Beauchemin The level of oxygen dissolved in the blood which is the thing that influences the availability of oxygen to the mitochondria varies according to well known scientific principles.…
- John_Hemming
- 3 yrs ago
- General Discussion
- Reported - view
Re: An interesting presentation.
@Paul Beauchemin There is an interesting question as to what research evidence there is that 15 mins of EWOT upregulates HIF more than say 20, 30 or 60 minutes just on an oxygen concentrator.…
- John_Hemming
- 3 yrs ago
- General Discussion
- Reported - view
Re: An interesting presentation.
@Fred Cloud The issue is the partial pressure of Oxygen. Then you have the reversion to norm which upregulates HIF. This is not something for just elite athletes.…
- John_Hemming
- 3 yrs ago
- 1
- General Discussion
- Reported - view
Re: An interesting presentation.
@Fred Cloud It depends on what detail you want. https://pubmed.ncbi.nlm.nih.gov/33466421/ is relevant so is https://pubmed.ncbi.nlm.nih.gov/33206062/
- John_Hemming
- 3 yrs ago
- General Discussion
- Reported - view
Re: An interesting presentation.
@Fred Cloud The idea of varioxia is to upregulate HIF. There are loads of papers on this.
- John_Hemming
- 3 yrs ago
- General Discussion
- Reported - view
Re: An interesting presentation.
I am using 20 mins from an O2 concentrator without exercise. That means the O2 concentrator can cope with the demands for litres of O2. It also means I am wearing it at the moment and can work and…
- John_Hemming
- 3 yrs ago
- 2
- General Discussion
- Reported - view

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