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Re: Berberine and Melatonin - can this reverse aging of cells?
This paper is interesting https://openheart.bmj.com/content/9/1/e001801.long It implies that adding Ferulic Acid to the Berberine/Melatonin combination would be helpful.
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Berberine and Melatonin - can this reverse aging of cells?
I now think that plasma citrate levels help in ensuring that stem cells differentiate. Melatonin helps with this by preventing oxidative stress, but the key part is the plasma citrate levels (a way…
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age
@Michael The difficulty is that isolating out the cause and effect of any particular change is difficult. People tell me I am less inflamed and the levine spreadsheet has a lower mortality,…
- John_Hemming
- 3 yrs ago
- 1
- Assessing Biological Age
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age
@John Hemming I am now running this every 4 weeks and now get DNAm at 49.43. I am wondering if the Molecular Hydrogen has accelerated the process of reducing inflammation.
- John_Hemming
- 3 yrs ago
- Assessing Biological Age
- Reported - view
Re: A hypothesis about Senescent Cells
@Fred Cloud The differentiation problems appear to link to a shortage of acetyl-coA.
- John_Hemming
- 3 yrs ago
- Senolytics Discussion
- Reported - view
Re: A hypothesis about Senescent Cells
I have now looked at other research to see if it supports the hypothesis or not. https://johnhemming.blogspot.com/2022/03/interleukin-10-review-of-research.…
- John_Hemming
- 3 yrs ago
- Senolytics Discussion
- Reported - view
Re: A hypothesis about Senescent Cells
I have done a blog post with further thoughts: https://johnhemming.blogspot.com/2022/02/gompertz-interleukin-10-and-gradual.html The Gompertz–Makeham law of mortality is a formula used to predict…
- John_Hemming
- 3 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: A hypothesis about Senescent Cells
@Karl because of a shortage of acetyl coa
- John_Hemming
- 3 yrs ago
- Senolytics Discussion
- Reported - view
A hypothesis about Senescent Cells

My hypothesis is that a large proportion of Senescent Cells are in fact Stem Cells which have not differentiated properly. What happens is they cause inflammation which causes a reduction in NF-κb…
- John_Hemming
- 3 yrs ago
- 7replies
- 191
- Senolytics Discussion
Re: HBOT and Rapamycin protocol
@John Hemming I have found a useful review of HIF which looks at lots of things including a link to autophagy and mitophagy.…
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Just Ordered Rapamycin w/ No Prescription
Looking at this issue I found this useful page https://www.rapamycin.news/t/list-of-reliable-online-pharmacies-for-buying-rapamycin-etc/437
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age
@JohnnyAdams Thanks for this. However, there is a problem with many of the javascript calculators in that they are prescriptive as to the units of measurement.…
- John_Hemming
- 3 yrs ago
- Assessing Biological Age
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age
@michael lustgarten Looking at this further (including looking at the correction) I cannot see how they calculate the denominator. In the end, however,…
- John_Hemming
- 3 yrs ago
- Assessing Biological Age
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age
@michael lustgarten Thank you for this. I have now corrected my own formula.
- John_Hemming
- 3 yrs ago
- 1
- Assessing Biological Age
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age
@michael lustgarten I noticed a discrepancy between your spreadsheet and the version I am using so I went back to source:…
- John_Hemming
- 3 yrs ago
- Assessing Biological Age
- Reported - view
Re: Mitochondria and the Epigenome
I have done a further video which looks further at this issue and what other aging problems arise directly from problems with the citrate carrier. https://www.youtube.com/watch?v=WVaUveAOaPg&t=114s
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Joe F There is, of course, an interesting question which is whether improving the health of cells at a cellular level leads to a greater tolerance of alcohol.…
- John_Hemming
- 3 yrs ago
- Senolytics Discussion
- Reported - view
Re: Stopping Metformin
I have found this which looks at Berberine evidence https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2467395/ It appears that Berberine reduces blood sugar for people with diabetes.…
- John_Hemming
- 3 yrs ago
- 1
- AMPK Activation
- Reported - view
Re: Mitochondria and the Epigenome
@Paul Beauchemin I just do Varioxyia with an Oxygen concentrator without exercise. My understanding about IR therapy is that it stimulates the creation of Serotonin which is then converted to…
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Stopping Metformin
@David That's why I think sharing information like this is important. We rely on research a lot of which is really good, but not all of it is right. My CGM reports for just 6 days might be quite…
- John_Hemming
- 3 yrs ago
- AMPK Activation
- Reported - view
Re: Stopping Metformin
Well I have six days of data that is comparable. The first two days I took 1 capsule of Berberine at 8.30am, the second two days I took none and the third two days I took 2 capsules of Berberine at…
- John_Hemming
- 3 yrs ago
- AMPK Activation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@JGC It is possible, but I have not looked at this. I use Eurovital which to me is reasonably consistent.
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@JGC There is a good point in that quality control of supplements is variable. It comes down to identifying brands which offer third party testing certificates,…
- John_Hemming
- 3 yrs ago
- Self-Experimentation
- Reported - view
Mitochondria and the Epigenome

I have done another video based upon more recent research.
- John_Hemming
- 3 yrs ago
- 3replies
- 98
- Self-Experimentation
Re: Stopping Metformin
@Karl At the moment it appears my blood sugar is slightly lower having stopped Berberine, but I actually need to do a more rigorous test probably cycling it every 2-3 days.…
- John_Hemming
- 3 yrs ago
- AMPK Activation
- Reported - view

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