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Fisetin to Clear Senescent Cells
Following studies with mice that showed significant senolytic clearance of senescent cells following large doses of the readily available flavenoid supplement Fisetin, my wife and I (ages 79 and 84) decided to try it. We have just completed two sets of massive Fisetin doses.
We had Life Extension blood-work done in October before the start, and we will have more again next week to observe any changes. The first set of Fisetin doses was on October 22-25 with 800 mg/day for three days followed by 600 mg on the fourth day, for a total of 4 g. I didn't notice much in the way of effects. Perhaps some reduction of small aches and pains and some increase in energy and mental acuity.
For the second set of doses done November 22-26, since we experienced no negative side effects in the first set we decided to increase the dosage a bit and to add 10 mg of BioPerine, a supplement that is reputed to magnify the effects and potency of flavenoids. For five days starting on Thanksgiving we took 500 mg of Fisetin and 10 mg of BioPerine twice per day, for a total of 5 g of Fisetin.
This time. I did experience one negative side effect. A few months ago, about 2 AM in the morning I awoke from a deep sleep and experienced a severe episode of vertigo. I turned over in bed, and the the whole room seemed to tilt. Suddenly, I didn't know which way was up. I staggered to the bathroom and vomited. The symptoms tapered off and disappeared in a few days, but it was a very distributing experience.
On the 2nd day of our 2nd Fisetin series, I experience a recurrence of that vertigo in the middle of the night, not as bad as my initial experience but still rather disturbing. I tolerated this mild vertigo and continued the treatment. My wife had no similar symptoms, and after my last dose I experienced no further vertigo symptoms.
On the positive side, following the second set of dosages I did feel very well, and very sharp and alert. This past weekend I ran my Shetland Sheepdog Taliesin in an AKC Canine Agility Trial in Mt. Vernon, WA, and we did very well, qualifying in 7 runs out of 15 and getting various colored placement ribbons. I was feeling quite sharp, and I even invented a new dog-handling technique that fixed an ongoing problem we were having.
Next week we will do the blood-work again, and I'll report any changes.
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karl kuffner said:
al liStaffan Olsson said:
similInteresting. I've had my 77 year old mother on the LE Senolytic Activator once weekly and she always reports feelings of well being after taking it. She reported very similar effects when I had her on mega doses of straight fisetin, which makes me believe that LE Senolytic Activator works just as well.
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Looks like Metformin has senomorphic effects. Is that the reason for the anti-aging effects?
https://www.frontiersin.org/articles/10.3389/fbioe.2021.730813/full
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It seems Rapamycin is also considered a senomorphic by some researchers.
https://academic.oup.com/biomedgerontology/article/76/6/1144/6126488
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The well known ITP reports Fisetin does not extend healthspan or lifespan in mice. It also did not remove senescent cells. Video here: https://www.youtube.com/watch?v=42PzfNs9egA&t=3294s
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Yes, very disappointing news from ITP. I will discontinue the use of Fisetin until the Mayo Clinic releases their results on human subjects in June. If they show no senescent cell removal, I will stop Fistein completely.
In other news, the ITP did show an increase in mouse longevity for Glycine\NAC supplementation of 24% which is huge. Studies using Glycine and NAC in humans over the age of 70 also showed very impressive results!