Fisetin to Clear Senescent Cells

Peter H. Howe I know it is disappointing in that we need an honest supplement reviewer.  Best thing we can do is buy supplements from well know and trusted retailers like Costco, and be sure to be educated enough to read the labels. 

Van If I do not get from Costco, I get from LEF. Note that Consumers Lab found Costco's green tea inferior as it had little or no EGGC but found Costco's   Kirkland fish oil one of the better brands. Consumers Lab also get into arguments with some manufactorers about some of the products it evaluates. I will still check Consumer Labs but with skepticism.

Denise Shugerman This may be a bit of a different approach from what you have tried, but you mention OA which I assume is osteoarthritis, and joint pain.  The first thing I would do is supplement with Borax.  (Yes, 20 Mule Team Borax...)  Borax is a clean and excellent source of Boron.  Boron has been shown to be a necessary trace element and low levels in the water and diet has been shown to correlate with higher levels of arthritis in both people and animals.  I have used this myself with excellent results and have recommended it to about 15 or so people and every one of them has experienced some level of improvement in their joint pain. 

You need to take at least 100mg of Borax (which contains about 10mg of Boron) a day, and if you take more initially it is not a problem.  The daily maintenance dose of 3mg a day is definitely not enough to get ahead of the curve on this.  You can think of it like table salt and take a fair pinch of it, as much as you would use for a good salting of ones eggs at breakfast.  I would recommend taking it like this for about 3 weeks.  I usually get results in a week and then forget to continue as I don't continue to have pain...  After this, you can supplement at 3mg if you like.

Dan Nave that is quite unconventional!  But I will try anything.  Thank you!

Denise Shugerman I'm hearing that fasting is an excellent way to cause autophagy.  It starts at 17 hours and if long enough you get stem cells released.   Google or duckduckgo fasting+autophagy.   

Robert Olin Yes, I know about fasting for autophagy...just waiting to get inspired to do it!

Denise Shugerman    I just had a big chocolate milkshake before starting my 1st 48 hour fast.   Autophagy is supposed to start at 17 hours.     Wish me luck.  

https://www.youtube.com/watch?v=5RT4qIO27uw

Robert Olin I find a nice approach to fasting is to eat my last meal on the afternoon of a Friday (2-3pm as work allows). Go through Saturday on green tea or black coffee -> add a little salt for electrolyte balance. Gently refeed on Sunday morning starting with a small amount of bone broth or protein. Should get you into the autophagy space. Frequency once a month for me. As long as your insulin levels are already tamed by having avoided snacking and the like for a while this degree of fasting is almost effortless, in fact it's pleasurable.

Jack Black Thanks for the advice.  I would prefer to snack all the time, but realize that I probably have insulin resistance and am also a hyper responder to carbs.   My wife is serious about feeding everything around her and can eat all the potatoes and rice she wants and never gains a pound and her HDL is 88.  

Robert Olin wow, if I had a chocolate milkshake before fasting, I'd be starving due to the sugar. Actually I am on the Peptide Semaglutide which controls sugar levels really well and makes you not hungry so i do not have an excuse to avoid fasting. I am just not disciplined, I want my coffee and I want it with milk every morning. The longevity institute I work with says 16 hours of fasting is good so I've done that here and there but yeah, 48 hours I'm sure is better.

Denise Shugerman Dr. Mindy say autophagy starts at 17 hour and slowly ramps up.   I'm like an alcoholic with food.   I'm either on the wagon or I'm not.   It's a lot easier once the decision is made.  No food today period.   Of course, I still have 1.5 days to go.   Talk is cheap.   Stem cell production is another interesting effect of fasting.   We'll see if my back stops aching so much.

Robert Olin I'd just like to clarify that autophagy does NOT "start" at the 17 hour mark, which is by no means a definitive dividing line in any case.  Actually, autophagy is happening ALL the time, but does increase with fasting. On different pages of her website (which also seems geared towards product sales), Dr. Mindy Pelz also cites Dr. Ohsumi's 13-15 hours and Naomi Whittel's 16 hours, but peer reviewed academic research has demonstrated that depending on the size and composition of the last full meal, the liver may use the last of its glucose reserves in as few as 8 to 12 hours, hence the popularity not only of the 18/6, but also the 16/8 and even 14/10 time restricted eating protocols.  My best wishes for your aching back!   

Brian Valerie Thanks for the information.  At 71 I can use all the autophagy I can get.   I understand some people also take fisetin and Quertcetin while fasting.   Others say go easy as your body starts detoxing when you are new to fasting and there might be a lot of toxins to deal with.   I'm at 18 hours.  Last night while in bed I fantasied eating a large BabyRuth candy bar.   Last thing I remembered as I fell asleep.  Better than counting sheep...grin.

Robert Olin At 40 hours into my fast I took my blood sugar and it was 99.   I've had lower when not fasting.   I assume my liver is dumping stored sugar?   I never got really hungry.   What I missed is the pleasure I get from eating.    This is the 1st time I've said no to my stomach, in my entire 71 years.    Hope to do it at least once a months.

Perhaps I'll take some fisetin  next time.

Denise Shugerman I was searching another topic, but saw your post.  20 years ago I also had L4-L5 issues with herniated disc.  Pain can radiate to all different areas.  I investigated various approaches, & decided on protocol which was 100% effective:  spinal decompression.

Likely you could find MRIs online, showing how the disc is actually inflated by the decompression.

In those days there was 1-2 high-end units, available only at MDs.  These days there are several computer controlled machines, with cost to MD / chiro for equipment from $13,000 = $150,000.

Individual treatments are generally about $70 - $120 per 40 minute session.  I think protocol is for 21 consecutive days.  When I started it was covered by insurance, but not sure these days.  I was unable to walk without a walker (about age 50 then,) but after session 10, about 50% improved; by session 17-18, fully recovered.

Every 3-4 years I get about 5 sessions to prevent possible back problems.  Very successful.

Related, but vits/supplements with decompression is helpful.  One I did not know then is CMO (Cetyl Myristoleate,) available both in capsules & topically.  It helps to shuttle various nutrients into the discs.  I assume F+Q etc. to remove senescent cells would be helpful too.