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Re: Intro to rapamycin @MAC Title of above paper link: "Intramuscular (IM) + Intranasal (IN) Rapamycin - A new paradigm for human longevity translation"
- MAC.
- MAC2
- 2 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Fisetin to Clear Senescent Cells @Van If it ever gets launched...7+ yrs and running.
- MAC.
- MAC2
- 2 yrs ago
- Self-Experimentation
- Reported - view
Re: Rapamycin and Fatigue From this paper on Rapamycin administration on a cohort of cancer patients, summary of side effects. Fatigue is very common, especially at higher effective dosing (eg.…
- MAC.
- MAC2
- 2 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Just Ordered Rapamycin w/ No Prescription @tommy https://forum.age-reversal.net/t/63jmdc/rapamycin-cost review some of the recent exchanges
- MAC.
- MAC2
- 2 yrs ago
- Self-Experimentation
- Reported - view
Re: Stopping Metformin @David Thanks David. I want to make sure I understand your comment. Are you suggesting that taking DHB daily will increase my Rapamycin AUC and reduce elimination of the weekly Rapamycin dosing?…
- MAC.
- MAC2
- 2 yrs ago
- AMPK Activation
- Reported - view
Re: Rapamycin Cost @Chris Los China commerce works in many dark and mysterious ways; middlemen, resellers, traders, etc. It definitely appears "shady" to western governance standards.…
- MAC.
- MAC2
- 2 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Stopping Metformin @David Here is one reference to Berberine and Exercise by Rhonda Patrick https://www.foundmyfitness.com/topics/berberine And another reference https://www.ironmagazine.…
- MAC.
- MAC2
- 2 yrs ago
- 1
- AMPK Activation
- Reported - view
Re: Rapamycin Cost @Vega Rejuvinated Are you buying this transdermal product for internal systemic mTOR modification or simply for topical skin anti-aging benefit? I assume you are looking for systemic,…
- MAC.
- MAC2
- 2 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost @Vega Rejuvinated Need a baseline reference panel, and then another after the Rapamycin dosing (assuming no other dietary/med/supplement changes, controlling for just Rapamycin).…
- MAC.
- MAC2
- 2 yrs ago
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost Thanks for the update. I haven't researched much this means of delivery, although yes, it does bypass gastric issues. The fact they abandoned oral capsules should be a signal to anyone taking oral…
- MAC.
- MAC2
- 2 yrs ago
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost Chris Los/Stanley. I can report the same experience. My first sourcing foray into Rapamycin was with http://rapamycin.store/. This was referenced as a reputable outfit out of Australia,…
- MAC.
- MAC2
- 2 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Variability Among Horvath-type DNA Methylation Age Tests I have a particular bias on neurodegenerative disease prevention (mom has AD), and two recent studies found NO correlation between the various clocks and predicting accelerated biological aging and…
- MAC.
- MAC2
- 2 yrs ago
- Assessing Biological Age
- Reported - view
Re: Correlation between Hearing Loss and EpiGenetic Age Very interesting, although not sure I agree with the authors making the connection between cardiovascular function and sensory hearing? Hearing I always thought was more directly connected to…
- MAC.
- MAC2
- 2 yrs ago
- Assessing Biological Age
- Reported - view
Re: Variability Among Horvath-type DNA Methylation Age Tests @isaac JOSEPH “We surely retest those few that have a substantive gap between Bioa nd Chrono ages” Frankly, this is a very damming admission of the erroneous results generated by your offering.…
- MAC.
- MAC2
- 2 yrs ago
- Assessing Biological Age
- Reported - view
Re: Dr Green new Rapamycin high dose @Fred Cloud you mean phenoage? That’s been proven to be 100% correlatable to human longevity/all cause mortality? Cite the studies.
- MAC.
- MAC2
- 2 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Dr Green new Rapamycin high dose @Van Go Van!! Perhaps you meant hypothalamus? As far as I know, the hippocampus is only a short term memory associated storage region, not a master cellular homeostasis signaller.…
- MAC.
- MAC2
- 2 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Dr Green new Rapamycin high dose @Mark Thimineur I wasn't casting aspersion to the anti-aging benefits of Rapamycin, otherwise I wouldn't be taking it. As you say, wild type mice only die of cancer,…
- MAC.
- MAC2
- 2 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Dr Green new Rapamycin high dose You could of course measure sdLDL (best), but TG/HDL is an excellent, readily tested proxy for sdLDL. So if your TG/HDL became dysregulated solely on Rapamycin intake,…
- MAC.
- MAC2
- 2 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Dr Green new Rapamycin high dose @Mark Thimineur Thank you for posting your experience, very informative for this community. Regarding "bloodwork", you only mentioned TC as apparently being somewhat dysregulated.…
- MAC.
- MAC2
- 2 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Interactions with rapamycin Did some more digging, observing mostly CYP3A4 INHIBITION findings with Curcuma Longa (the active ingredient in the Curcumin I take). Here's one pretty definitive IN VIVO humans that I think puts…
- MAC.
- MAC2
- 2 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Iron dumping @John One should always listen to their trusted doctor for real concerns as to root cause of significant changes to iron biomarkers. But in my deep dive of the iron/health literature,…
- MAC.
- MAC2
- 2 yrs ago
- General Discussion
- Reported - view
Re: Iron dumping So far in this journey, yes, no apparent issues. I am very fit, not sure if I have muscular/aerobic "reserve", such that I can tolerate lower limits of cellular/blood iron and still function without…
- MAC.
- MAC2
- 2 yrs ago
- General Discussion
- Reported - view
Re: Iron dumping Care to share your lab panels including CBC and relevant iron markers? What about diet, do you eat sufficient iron? And donations, how frequent do you donate? I donate every 8 weeks,…
- MAC.
- MAC2
- 2 yrs ago
- 1
- General Discussion
- Reported - view
Re: Interactions with rapamycin I wasn't aware of the Curcumin/CYP3A4 interaction. I take Curcumin daily (500 mg). Not sure what literature you are referencing, but this study seems relevant:…
- MAC.
- MAC2
- 2 yrs ago
- 3
- Rapamycin Discussion
- Reported - view
Re: Iron dumping Do a full iron panel and check your saturation. Ferritin is a very poor measure of cellular iron stores. https://forum.age-reversal.net/t/g9hxa1c/is-iron-the-next-anti-aging-target
- MAC.
- MAC2
- 2 yrs ago
- General Discussion
- Reported - view

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