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Re: Variability Among Horvath-type DNA Methylation Age Tests @isaac JOSEPH “We surely retest those few that have a substantive gap between Bioa nd Chrono ages” Frankly, this is a very damming admission of the erroneous results generated by your offering.…
- MAC.
- MAC2
- 9 hrs ago
- Assessing Biological Age
- Reported - view
Re: Dr Green new Rapamycin high dose @Fred Cloud you mean phenoage? That’s been proven to be 100% correlatable to human longevity/all cause mortality? Cite the studies.
- MAC.
- MAC2
- 3 days ago
- Rapamycin Discussion
- Reported - view
Re: Dr Green new Rapamycin high dose @Van Go Van!! Perhaps you meant hypothalamus? As far as I know, the hippocampus is only a short term memory associated storage region, not a master cellular homeostasis signaller.…
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- MAC2
- 3 days ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Dr Green new Rapamycin high dose @Mark Thimineur I wasn't casting aspersion to the anti-aging benefits of Rapamycin, otherwise I wouldn't be taking it. As you say, wild type mice only die of cancer,…
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- MAC2
- 3 days ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Dr Green new Rapamycin high dose You could of course measure sdLDL (best), but TG/HDL is an excellent, readily tested proxy for sdLDL. So if your TG/HDL became dysregulated solely on Rapamycin intake,…
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- MAC2
- 4 days ago
- Rapamycin Discussion
- Reported - view
Re: Dr Green new Rapamycin high dose @Mark Thimineur Thank you for posting your experience, very informative for this community. Regarding "bloodwork", you only mentioned TC as apparently being somewhat dysregulated.…
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- MAC2
- 4 days ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Interactions with rapamycin Did some more digging, observing mostly CYP3A4 INHIBITION findings with Curcuma Longa (the active ingredient in the Curcumin I take). Here's one pretty definitive IN VIVO humans that I think puts…
- MAC.
- MAC2
- 8 days ago
- Rapamycin Discussion
- Reported - view
Re: Iron dumping @John One should always listen to their trusted doctor for real concerns as to root cause of significant changes to iron biomarkers. But in my deep dive of the iron/health literature,…
- MAC.
- MAC2
- 9 days ago
- General Discussion
- Reported - view
Re: Iron dumping So far in this journey, yes, no apparent issues. I am very fit, not sure if I have muscular/aerobic "reserve", such that I can tolerate lower limits of cellular/blood iron and still function without…
- MAC.
- MAC2
- 10 days ago
- General Discussion
- Reported - view
Re: Iron dumping Care to share your lab panels including CBC and relevant iron markers? What about diet, do you eat sufficient iron? And donations, how frequent do you donate? I donate every 8 weeks,…
- MAC.
- MAC2
- 10 days ago
- 1
- General Discussion
- Reported - view
Re: Interactions with rapamycin I wasn't aware of the Curcumin/CYP3A4 interaction. I take Curcumin daily (500 mg). Not sure what literature you are referencing, but this study seems relevant:…
- MAC.
- MAC2
- 12 days ago
- 3
- Rapamycin Discussion
- Reported - view
Re: Iron dumping Do a full iron panel and check your saturation. Ferritin is a very poor measure of cellular iron stores. https://forum.age-reversal.net/t/g9hxa1c/is-iron-the-next-anti-aging-target
- MAC.
- MAC2
- 2 wk ago
- General Discussion
- Reported - view
Re: Are members here having real results with rapamycin? @Paul Beauchemin I've been taking 8mg/week. I've also noticed significant improvements in eGFR, and liver enzymes ALT/GGT, and a massive reduction in URIC acid.…
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- MAC2
- 1 mth ago
- 4
- Rapamycin Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? @Jack Black Yeah, Natto isn't so bad. I've had it 2 days in a row now, easily adaptable to diet. Darker hair, great! Nutrient dense whole foods rock.
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- MAC2
- 1 mth ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? @Staffan Olsson Investigation of biologically active amines in some selected edible mushrooms https://sci-hub.se/https://doi.org/10.1016/j.jfca.2019.103375 See attached.…
Attachments
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- 1 mth ago
- 1
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? @Staffan Olsson Do you eat mushrooms, especially some of the more exotic varieties? They have the highest Spermidine levels of plant origin, save for wheat germ.…
Attachments
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- MAC2
- 1 mth ago
- 1
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? @chuck stanley Natto is normally nasty...taste is not too difficult, but room temperature Natto odour (it comes frozen) is VERY strong. I let it defrost a bit, no palatability problem.…
- MAC.
- MAC2
- 1 mth ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? @MAC. Higher spermidine intake is linked to lower mortality: a prospective population-based study https://academic.oup.com/ajcn/article/108/2/371/5046172 "The difference in mortality risk between…
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- MAC2
- 1 mth ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? @chuck stanley Rethinking, 1mg/day is indeed quite low AND the cost of the supplements. So I took a closer look at other Spermidine intake options, specifically food sourced.…
Attachments
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- 1 mth ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? This is what I have on file from vendor: "One serving yields 1mg spermidine (some customers take up to 3 per day). Our matrix also contains several extracts from natural sources that act to support…
- MAC.
- MAC2
- 1 mth ago
- 1
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? I've been taking this Spermidine product for a couple of years now. https://lzrlabs.net/home-page
- MAC.
- MAC2
- 1 mth ago
- General Discussion
- Reported - view
Re: Rapamycin Cost I started on Rapamycin January 2021. To truly understand/monitor/optimize the peak concentration and total AUC of dosing regiment, I studied the blood concentration kinetics literature,…
Attachment
- MAC.
- MAC2
- 2 mths ago
- 1
- Self-Experimentation
- Reported - view
Re: Current longevity protocol: Should I add rapamycin? @Simon Smith that’s not the only hemo gene, there are several others, and depending on what test and genome array that was available, it might only catch the main ones.
- MAC.
- MAC2
- 3 mths ago
- Self-Experimentation
- Reported - view
Re: Current longevity protocol: Should I add rapamycin? @Simon Smith Do you know your genetic iron genes? For example, from a 23andme test? > https://www.xcode.life/23andme-raw-data/hereditary-hemochromatosis-get-your-hfe-status-using-dna-raw-data/ >…
- MAC.
- MAC2
- 3 mths ago
- Self-Experimentation
- Reported - view
Re: Current longevity protocol: Should I add rapamycin? @Simon Smith yes aware of the literature on metformin/exercise blunting. I don’t take metformin. With my ketogenic area under the curve, I am already blunting AMPK,…
- MAC.
- MAC2
- 3 mths ago
- Self-Experimentation
- Reported - view

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