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Re: Intro to rapamycin
@MAC Title of above paper link: " Intramuscular (IM) + Intranasal (IN) Rapamycin - A new paradigm for human longevity translation "
MAC.
MAC2
3 mths ago
Rapamycin Discussion
Reported - view
Re: Fisetin to Clear Senescent Cells
@Van If it ever gets launched...7+ yrs and running.
MAC.
MAC2
9 mths ago
Self-Experimentation
Reported - view
Re: Rapamycin and Fatigue
From this paper on Rapamycin administration on a cohort of cancer patients, summary of side effects. Fatigue is very common, especially at higher effective dosing (eg.…
MAC.
MAC2
9 mths ago
Rapamycin Discussion
Reported - view
Re: Just Ordered Rapamycin w/ No Prescription
@tommy https://forum.age-reversal.net/t/63jmdc/rapamycin-cost review some of the recent exchanges
MAC.
MAC2
11 mths ago
Self-Experimentation
Reported - view
Re: Stopping Metformin
@David Thanks David. I want to make sure I understand your comment. Are you suggesting that taking DHB daily will increase my Rapamycin AUC and reduce elimination of the weekly Rapamycin dosing?…
MAC.
MAC2
11 mths ago
AMPK Activation
Reported - view
Re: Rapamycin Cost
@Chris Los China commerce works in many dark and mysterious ways; middlemen, resellers, traders, etc. It definitely appears "shady" to western governance standards.…
MAC.
MAC2
11 mths ago
1
Self-Experimentation
Reported - view
Re: Stopping Metformin
@David Here is one reference to Berberine and Exercise by Rhonda Patrick https://www.foundmyfitness.com/topics/berberine And another reference https://www.ironmagazine.…
MAC.
MAC2
11 mths ago
1
AMPK Activation
Reported - view
Re: Rapamycin Cost
@Vega Rejuvinated Are you buying this transdermal product for internal systemic mTOR modification or simply for topical skin anti-aging benefit? I assume you are looking for systemic,…
MAC.
MAC2
11 mths ago
1
Self-Experimentation
Reported - view
Re: Rapamycin Cost
@Vega Rejuvinated Need a baseline reference panel, and then another after the Rapamycin dosing (assuming no other dietary/med/supplement changes, controlling for just Rapamycin).…
MAC.
MAC2
11 mths ago
Self-Experimentation
Reported - view
Re: Rapamycin Cost
Thanks for the update. I haven't researched much this means of delivery, although yes, it does bypass gastric issues. The fact they abandoned oral capsules should be a signal to anyone taking oral…
MAC.
MAC2
11 mths ago
Self-Experimentation
Reported - view
Re: Rapamycin Cost
Chris Los/Stanley. I can report the same experience. My first sourcing foray into Rapamycin was with http://rapamycin.store/ . This was referenced as a reputable outfit out of Australia,…
MAC.
MAC2
11 mths ago
2
Self-Experimentation
Reported - view
Re: Variability Among Horvath-type DNA Methylation Age Tests
I have a particular bias on neurodegenerative disease prevention (mom has AD), and two recent studies found NO correlation between the various clocks and predicting accelerated biological aging and…
MAC.
MAC2
1 yr ago
Assessing Biological Age
Reported - view
Re: Correlation between Hearing Loss and EpiGenetic Age
Very interesting, although not sure I agree with the authors making the connection between cardiovascular function and sensory hearing? Hearing I always thought was more directly connected to…
MAC.
MAC2
1 yr ago
Assessing Biological Age
Reported - view
Re: Variability Among Horvath-type DNA Methylation Age Tests
@isaac JOSEPH “We surely retest those few that have a substantive gap between Bioa nd Chrono ages” Frankly, this is a very damming admission of the erroneous results generated by your offering.…
MAC.
MAC2
1 yr ago
Assessing Biological Age
Reported - view
Re: Dr Green new Rapamycin high dose
@Fred Cloud you mean phenoage? That’s been proven to be 100% correlatable to human longevity/all cause mortality? Cite the studies.
MAC.
MAC2
1 yr ago
Rapamycin Discussion
Reported - view
Re: Dr Green new Rapamycin high dose
@Van Go Van!! Perhaps you meant hypothalamus? As far as I know, the hippocampus is only a short term memory associated storage region, not a master cellular homeostasis signaller.…
MAC.
MAC2
1 yr ago
1
Rapamycin Discussion
Reported - view
Re: Dr Green new Rapamycin high dose
@Mark Thimineur I wasn't casting aspersion to the anti-aging benefits of Rapamycin, otherwise I wouldn't be taking it. As you say, wild type mice only die of cancer,…
MAC.
MAC2
1 yr ago
1
Rapamycin Discussion
Reported - view
Re: Dr Green new Rapamycin high dose
You could of course measure sdLDL (best), but TG/HDL is an excellent, readily tested proxy for sdLDL. So if your TG/HDL became dysregulated solely on Rapamycin intake,…
MAC.
MAC2
1 yr ago
Rapamycin Discussion
Reported - view
Re: Dr Green new Rapamycin high dose
@Mark Thimineur Thank you for posting your experience, very informative for this community. Regarding "bloodwork", you only mentioned TC as apparently being somewhat dysregulated.…
MAC.
MAC2
1 yr ago
1
Rapamycin Discussion
Reported - view
Re: Interactions with rapamycin
Did some more digging, observing mostly CYP3A4 INHIBITION findings with Curcuma Longa (the active ingredient in the Curcumin I take). Here's one pretty definitive IN VIVO humans that I think puts…
MAC.
MAC2
1 yr ago
1
Rapamycin Discussion
Reported - view
Re: Iron dumping
@John One should always listen to their trusted doctor for real concerns as to root cause of significant changes to iron biomarkers. But in my deep dive of the iron/health literature,…
MAC.
MAC2
1 yr ago
General Discussion
Reported - view
Re: Iron dumping
So far in this journey, yes, no apparent issues. I am very fit, not sure if I have muscular/aerobic "reserve", such that I can tolerate lower limits of cellular/blood iron and still function without…
MAC.
MAC2
1 yr ago
General Discussion
Reported - view
Re: Iron dumping
Care to share your lab panels including CBC and relevant iron markers? What about diet, do you eat sufficient iron? And donations, how frequent do you donate? I donate every 8 weeks,…
MAC.
MAC2
1 yr ago
1
General Discussion
Reported - view
Re: Interactions with rapamycin
I wasn't aware of the Curcumin/CYP3A4 interaction. I take Curcumin daily (500 mg). Not sure what literature you are referencing, but this study seems relevant:…
MAC.
MAC2
1 yr ago
3
Rapamycin Discussion
Reported - view
Re: Iron dumping
Do a full iron panel and check your saturation. Ferritin is a very poor measure of cellular iron stores. https://forum.age-reversal.net/t/g9hxa1c/is-iron-the-next-anti-aging-target
MAC.
MAC2
1 yr ago
General Discussion
Reported - view
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MAC2
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