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Re: Are members here having real results with rapamycin? @Paul Beauchemin I've been taking 8mg/week. I've also noticed significant improvements in eGFR, and liver enzymes ALT/GGT, and a massive reduction in URIC acid.…
- MAC.
- MAC2
- 3 yrs ago
- 4
- Rapamycin Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? @Jack Black Yeah, Natto isn't so bad. I've had it 2 days in a row now, easily adaptable to diet. Darker hair, great! Nutrient dense whole foods rock.
- MAC.
- MAC2
- 3 yrs ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? @Staffan Olsson Investigation of biologically active amines in some selected edible mushrooms https://sci-hub.se/https://doi.org/10.1016/j.jfca.2019.103375 See attached.…
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- MAC.
- MAC2
- 3 yrs ago
- 2
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? @Staffan Olsson Do you eat mushrooms, especially some of the more exotic varieties? They have the highest Spermidine levels of plant origin, save for wheat germ.…
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- MAC.
- MAC2
- 3 yrs ago
- 1
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? @chuck stanley Natto is normally nasty...taste is not too difficult, but room temperature Natto odour (it comes frozen) is VERY strong. I let it defrost a bit, no palatability problem.…
- MAC.
- MAC2
- 3 yrs ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? @MAC. Higher spermidine intake is linked to lower mortality: a prospective population-based study https://academic.oup.com/ajcn/article/108/2/371/5046172 "The difference in mortality risk between…
- MAC.
- MAC2
- 3 yrs ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? @chuck stanley Rethinking, 1mg/day is indeed quite low AND the cost of the supplements. So I took a closer look at other Spermidine intake options, specifically food sourced.…
Attachments
- MAC.
- MAC2
- 3 yrs ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? This is what I have on file from vendor: "One serving yields 1mg spermidine (some customers take up to 3 per day). Our matrix also contains several extracts from natural sources that act to support…
- MAC.
- MAC2
- 3 yrs ago
- 1
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? I've been taking this Spermidine product for a couple of years now. https://lzrlabs.net/home-page
- MAC.
- MAC2
- 3 yrs ago
- General Discussion
- Reported - view
Re: Rapamycin Cost I started on Rapamycin January 2021. To truly understand/monitor/optimize the peak concentration and total AUC of dosing regiment, I studied the blood concentration kinetics literature,…
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- MAC.
- MAC2
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Current longevity protocol: Should I add rapamycin? @Simon Smith that’s not the only hemo gene, there are several others, and depending on what test and genome array that was available, it might only catch the main ones.
- MAC.
- MAC2
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Current longevity protocol: Should I add rapamycin? @Simon Smith Do you know your genetic iron genes? For example, from a 23andme test? > https://www.xcode.life/23andme-raw-data/hereditary-hemochromatosis-get-your-hfe-status-using-dna-raw-data/ >…
- MAC.
- MAC2
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Current longevity protocol: Should I add rapamycin? @Simon Smith yes aware of the literature on metformin/exercise blunting. I don’t take metformin. With my ketogenic area under the curve, I am already blunting AMPK,…
- MAC.
- MAC2
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Weekly rapamycin and protein/resistance training regimen I am high DAILY exerciser, both resistance and aerobic. I take my Rapamycin once per week, irrespective of my normal meal timing/macros or exercise. Rapamycin has a half life of 60-80 hrs.…
- MAC.
- MAC2
- 3 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Current longevity protocol: Should I add rapamycin? @Simon Smith Hi Simon from a fellow Torontonian. 56 yo male. Fired by family doctor, took on a functional medicine doctor (FMD), focused on prevention like most people here.…
- MAC.
- MAC2
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Calorie Restriction, Eat Once Every Other Day (EOD Diet) @Jimmy2 Had to got 2.0 as well. Thanks for sharing the Siim Land links...indeed, a true "mini-me". https://siimland.com His teachings, practices and scientific rationals are pretty much exactly why…
- MAC.
- MAC2
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view

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