Dasatinib

Paul Beauchemin Thank you  I will take a look

Pablo Reinaldos López   I can't say exactly what benefits since I am doing as prevention.  I did not have a problem I wanted to correct.  I have been following life extension for many years and do many things so It's hard to know what exactly is helping.    I know I am much healthier than my friends around the same age.

Rob8311   Do you do both?  I have been thinking about Rapamycin.   I have gotten any information about doing both.

ssny. sotero Yes, I use both.  At age 68 the use of both is clearly appropriate.  Dr Green says one should begin senolytics at age 40-45.  Offhand, I don't know what age is recommended for starting rapamycin.  Up to a certain age, mTORC1, which you are trying to suppress, does not work against you.

Rob8311  Thanks Rob.  What is the dose you take? Is it based on weight?  Is it less because you take the dasatinib? Do you do the 2 week dasatinib/quercetin every 6 months?

ssny. sotero Sirolimus 6mg per week, per Dr. Green, if based on weight that is his calculation, not mine.  No, I think the two treatments work in entirely different ways and do not conflict.  I think the more ways you fight for longevity, the better.  I am just restarting the D+Q.  My two 17 year old Boston Terriers died in March, so I am still recovering.  I am going to try to build up to 3 weeks every 3 months, and include large doses of fisetin as well.  I am adding black pepper extract to increase bioavailability, and also apigenin to potentiate the dasatinib.  We'll see how it goes.  I have previously taken 250mg of Dasatinib at once without noticing any effects.  I have also taken large amounts of fisetin; like, the whole bottle!  I think every three months makes sense because the senescent cells are coming back by the second month or so.  By the way, I read a study that showed Quercitin is important because it destroys survival pathways of senescent cells, even though it doesn't kill them itself.  Then the senolytics come along and have a much easier time of it.  Quercitin is also good for lots of other things, like kidneys - we gotta watch our kidneys!

Rob8311 I wanted to ask you the senescent cells that you kill don't come back, right? The ones that come are new created by the body, is that so? Have any other questions noticed any benefits for your health with the combination of dasatinib and quercetin? What source apigenin do you get that helps in the removal of senescent cells through dasatinib?

Rob8311 Thanks for the info Rob. So sorry to hear about your dogs.  Losing both at one time is so difficult.  Can you point me in the direction of information on dosage of Fisten. I have it but not sure how to take it. Also any info on the black pepper extract to increase bioavailability, and apigenin to potentiate the dasatinib. I have never heard of these.  Thank you

Rob8311 Im still looking for a source for the Dasatinib

Pablo Reinaldos López When cells go through apoptosis they disintegrate, no comeback.  Senescent cells are older cells that are put in that state by the body.  You can find tons of material just by Googling this.  Haven't noticed too much from the D+Q but haven't given a consistent treatment over time yet.  The first time I took a big dose of fisetin I felt incredible for a few days and for weeks after could stay up all night and not feel the effects the next day, not that I recommend that.  I got apigenin from Swanson Vitamins.  I only read that it helps with dasatinib.  Don't take my word for it.  Do your research.  Dave Asprey, the Bulletproof guy, says studies show black pepper is bad for the gut (leaky gut, I think), but I just read that and haven't had a chance to look up the studies.  It does enhance all sorts of things - Google it.

ssny. sotero Check out the Dr. Green website I mentioned for fisetin dosing.  Also, why not contact him bout the dasatinib? It's worth a shot.  Or see if BonHoa is offering it still.  Google bioperine and black pepper extract.  I have just started reading about apigenin.  It sounds great, actually, but don't take my word for it.  Use Google and read the studies on these things.  They look incomprehensible at first, but start by reading the summaries and conclusions, and read more as your vocabulary grows.

Rob8311 sorry to hear of your dogs. I think I read that you had them on rapamycin. Do you think it had an effect?

I’ve put my 18 kg 14.5 yo dog on 2mg every 5 days. Been about 6 weeks now.

Paul Beauchemin Well, they lived to 16-1/2 and 17, when few Boston Terriers make it past 14.  Since dogs age 6 or so times faster than us, I don't think you need a week to protect mTORC2.  I was giving 1mg MWF.  They weighed 8 kg.

Rob8311 very impressive results for Boston terriers life extension. So when did you start them on it and was specific type of rapamycin was it? 

Joe smith Sirolimus (Zydus).  To be honest, I would start giving your dog 50 mg Quinogel (SwansonVitamins) with every meal, milk thistle for liver (Life Extension has great caps), and lots of kidney support (quercitin, ALCAR, curcumin, pyridoxal-5-phosphate, astaxanthin, etc., ).

Rob8311 And krill oil gelcaps at least once a day (Costco has good ones).

Rob8311 Plus, get them off kibble and on a balanced diet.

Rob8311  I have been going to Dr. Green yearly and taking rapamycin for over 3 years. I very much enjoy speaking with him during my visit.  He really does know his science!

I am convinced of rap's efficacy. In fact, last few years I feel at least a decade younger. Age-related aches and pains, for the most part, are gone. I can't imagine this is the result of the placebo effect. Besides this, my bloodwork has consistently improved over time. And I barely exercise these days.  I purchased for the first time last year Dasatinib through him (via US Compounding Pharmacy which I believe only works with physicians). Unfortunately, the price for 24 50 mg. pills increased to $350 from $250 the same time last year. 

@Jack Silberman Rapa is very important to me, worth the $212 I pay at Ralph's pharmacy using GoodRx for 2 months @7 tablets/week.  I have not found it to be a substitute for exercise at all, though.  On the plus side, I am 70 and putting 630 lbs (about to increase to 720) on the leg press, which I doubt would be happening without rapa.