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Re: Rapamycin Cost @Ellis Toussier I think half-life of 62 hours plays a big part in side effects. Someone taking this daily will build up higher levels in their blood than someone taking weekly.
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Intermittent fasting increases testosterone in older males? @Dan has this changed free testosterone or just total?
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- Test Results Discussions
- Reported - view
Re: Intermittent fasting increases testosterone in older males? Never had a BMI of 19! Currently at 12.
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- Test Results Discussions
- Reported - view
Re: Paul's self experimentation Took a dose of Dasatinab yesterday. Used Dasapro from the anti-aging store. $89 for 360 mg. Split in two will take a second dose next week. Experienced diarrhea and a slight headache at bedtime but…
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Senolytics From Dr Greens website In a 2018 paper Blagosklonny states, "It has been calculated than rapamycin slows geroconversion by approximately 3-fold". This means rapamycin slows formation of senescent…
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Senolytics @Mark Thimineur by this logic taking metformin and rapamycin together would not be useful since both deregulate mTor. however, a recent study showed targeting insulin and mTor pathways showed 400%…
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: [Survey]: What motivates your interest in Rescue Elders? A decade of caring for parents suffering from dementia and Parkinson’s and not wanting to put my wife or children through that by living healthy until the day I pass
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- 1
- Questions & Answers
- Reported - view
Nutritional framework
This deserves some discussion https://peterattiamd.com/my-nutritional-framework/
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- 30
- General Discussion
Re: Details of dasatinib + quercetin study https://youtu.be/VAVBZIoed-c
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Details of dasatinib + quercetin study Going to take D & Q this week and trying to decide dosage. Chart above shows ~ 150 mg & 1500 mg Q one day for 2 consecutive weeks. Just listened to this video describing study where participants…
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Kaufmann Protocol Analysis @JGC thanks works perfectly
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Kaufmann Protocol Analysis @JGC here’s the Dropbox troubleshooting page. I wonder if your links were banned https://help.dropbox.com/files-folders/share/shared-link-stopped-working
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Kaufmann Protocol Analysis I cannot view this or the link to the spreadsheet. Appreciate you creating it but I don't think the way you shared works
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Key Studies and Articles Interesting differentiation between senostatics like metformin and rapamycin and senolytics like dasatinab
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- General Discussion
- Reported - view
Re: Senolytics @Mark Thimineur I think Josh Mitteldorf is trying to answer that with http://data-beta.net/
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin @JGC yes
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Sources for inexpensive prescription Rapamycin @Steve Roedde do you have an extruder to compound thoroughly?
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Rapamycin Cost Ordered 250 mg of Rapamycin from dropshipmd Expected delivery is Monday. Cost was $550 including shipping so about $2.20 per mg. Sent money via Western Union.…
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Medical Research Just one example https://www.latimes.com/business/story/2019-12-30/drug-breakthroughs-of-the-2010s
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- 1
- General Discussion
- Reported - view
Re: Medical Research Humans have intrinsic confirmation biases. We seek out data that confirms what we believe to be true and disregard reality.
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- 1
- General Discussion
- Reported - view
Re: Introduction to NAD+ also questions about whether a senolytics treatment beforehand will make NAD more effective James Clement has a mass spectrometer that can measure NAD levels so will soon know how effective various…
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- 1
- NAD+ Restoration
- Reported - view
Re: Introduction to NAD+ https://youtu.be/n9SQjWxWMkE second Half of this video has great discussion on NAD top takeaways only have 10% of normal levels by 70 and nearly none by 80 alcohol and disease deplete levels quite a…
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- 1
- NAD+ Restoration
- Reported - view
Re: Paul's self experimentation So I started taking 5 mg Rapamycin at the start of Dec. This week the morning after I woke up with unexplained anxiety which has gone away after a couple of days. One of the noted side effects
- Paul Beauchemin
- Paul_Beauchemin
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Metformin: worth it? and what to expect I’ve been taking 850 mg metformin 2x per day for 5 years now. Not diabetic, took after diagnosis of prostate cancer at age 62. Doctors said PC was too low grade to treat so I researched and settled…
- Paul Beauchemin
- Paul_Beauchemin
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Paul's self experimentation @Karl no, I'm not diabetic although my Dad was and one of my brothers are.
- Paul Beauchemin
- Paul_Beauchemin
- 5 yrs ago
- Self-Experimentation
- Reported - view

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Paul Beauchemin

Paul_Beauchemin

All over America in my RV

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Joined: Sun Dec 15 22:30:53 UTC 2019

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Retired after 40 years at DuPont
MS Chemical Engineering