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Re: Fisetin to Clear Senescent Cells
@Dorian Gray thanks for the feedback. I would think it will take awhile to see the positive effects.
- Karl.1
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
ResTorbio failure

Sorry if this has already been discussed but I couldn’t find it in a search. With all th good things we’ve heard about Rapamycin and mTor inhibition, any idea why the ResTorbio trial failed?…
- Karl.1
- 5 yrs ago
- 2replies
- 148
- Rapamycin Discussion
Re: Fisetin to Clear Senescent Cells
@Mel don’t know Bill’s source of info. I have in my notes Fisetin 1 to 1.5 gms per day for 2 days. https://clinicaltrials.gov/ct2/show/NCT03430037?cond=fisetin&cntry=US&draw=1&rank=2
- Karl.1
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Should we be taking oral NR/NMN?
A new video from Dr. Patrick https://www.foundmyfitness.com/episodes/nad-nr-nmn
- Karl.1
- 5 yrs ago
- 1
- NAD+ Restoration
- Reported - view
Re: Glucose level a proxy for sirolimus level?
Do we know enough about how Rapamycin woks that levels matter? Are you ensuring that levels go to zero?
- Karl.1
- 5 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Rapamycin Cost
@Van you may be correct in your n of 1, but to generalize would be erroneous. Saying that dosing is easy for a drug used for unapproved indication, that has not been adequately studied in humans for…
- Karl.1
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Intermittent fasting and rapamycin
I doubt there have been adequate human studies on either Rapamycin or Fasting, let alone all the various IF regiments and how they interact with Rapamycin.…
- Karl.1
- 5 yrs ago
- General Discussion
- Reported - view
Re: Toniq Resveratrol?
Actually it “Toniiq” with two i’s
- Karl.1
- 5 yrs ago
- Questions & Answers
- Reported - view
Toniq Resveratrol?

Does anyone have information on quality of brand “Toniq”? They sell a Resveratrol that is higher dose than many others.
- Karl.1
- 5 yrs ago
- 1reply
- 49
- Questions & Answers
Re: NAD and Statins?
Doubt there would be an interaction, but no way to get a definite answer as it isn’t a drug, and hasn’t been a supplement very long.
- Karl.1
- 5 yrs ago
- General Discussion
- Reported - view
Re: NUCHIDO
@Garnett Faulkner what is source of nad nasal spray
- Karl.1
- 5 yrs ago
- 1
- NAD+ Restoration
- Reported - view
Re: Rapamycin vs Metformin
@Staffan Olsson great article. Challenging to find these compounds in available supplements. Would like to find a Withaferin A only supplement.
- Karl.1
- 5 yrs ago
- AMPK Activation
- Reported - view
Re: Should you get a micronutrient test?
For micronutrients, do you know How they determined “normal” values?
- Karl.1
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Details of dasatinib + quercetin study
@Paul Beauchemin I think there was also one with 50 D and 500 Q x 5 days.
- Karl.1
- 5 yrs ago
- Senolytics Discussion
- Reported - view
Re: Bill Faloon's Recent Blood Test Results
Not sure what to make of this data without baseline data. What would results be without the supplements? Does Bill just have good Genes?
- Karl.1
- 5 yrs ago
- Test Results Discussions
- Reported - view
Re: Rapamycin Cost
@Mark Thimineur that is the problem with all of this - insufficient data.
- Karl.1
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost
@Mark Thimineur are you saying Dr Green is taking 15 mg (.2 mg/kg)? Are basing this on actual weight or lean body mass?
- Karl.1
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Kaufmann Protocol Analysis
I have not read her book, but have gone through the website. I think her choice of supplements is a bit arbitrary, with key supplements as you mentioned missing.…
- Karl.1
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Lisinopril and Self Experimentation.
Epocrates is a great website and app for looking up drug interactions. No interactions listed for Lisinopril with either Metformin or dasatanib.
- Karl.1
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Key Studies and Articles
@Larry Thanks finding that study. She also states on website that Quercetin is the ONLY otc senolytic which is wrong - Fisetin, Curcumin and others.
- Karl.1
- 5 yrs ago
- General Discussion
- Reported - view
Re: Key Studies and Articles
Kaufmann paper on senolytics https://static1.squarespace.com/static/5aac3477f8370a964b2550c7/t/5d91091dbd027f6ecf806f8f/1569786142074/Senescent+Cells+%26+Senolytic+Therapy.pdf
- Karl.1
- 5 yrs ago
- 2
- General Discussion
- Reported - view
Re: Rapamycin Cost
@Ellis Toussier book idea sounds great.
- Karl.1
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost
@Steve Roedde that is a great find assuming there are no significant contaminants. Several other interesting products they sell. I’m always a bit leery of Chinese and Indian products.
- Karl.1
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost
@Steve Roedde are you saying that you did get legitimate Rapamycin?
- Karl.1
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Intro to rapamycin
@Sanford Finley regular feedback will be greatly appreciated. Good luck.
- Karl.1
- 5 yrs ago
- 1
- Rapamycin Discussion
- Reported - view

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