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Re: Fisetin to Clear Senescent Cells
@Dorian Gray thanks for the feedback. I would think it will take awhile to see the positive effects.
Karl
Karl.1
4 yrs ago
1
Self-Experimentation
Reported - view
ResTorbio failure
Sorry if this has already been discussed but I couldn’t find it in a search. With all th good things we’ve heard about Rapamycin and mTor inhibition, any idea why the ResTorbio trial failed?…
Karl
Karl.1
4 yrs ago
2
replies
147
Rapamycin Discussion
Re: Fisetin to Clear Senescent Cells
@Mel don’t know Bill’s source of info. I have in my notes Fisetin 1 to 1.5 gms per day for 2 days. https://clinicaltrials.gov/ct2/show/NCT03430037?cond=fisetin&cntry=US&draw=1&rank=2
Karl
Karl.1
4 yrs ago
Self-Experimentation
Reported - view
Re: Should we be taking oral NR/NMN?
A new video from Dr. Patrick https://www.foundmyfitness.com/episodes/nad-nr-nmn
Karl
Karl.1
4 yrs ago
1
NAD+ Restoration
Reported - view
Re: Glucose level a proxy for sirolimus level?
Do we know enough about how Rapamycin woks that levels matter? Are you ensuring that levels go to zero?
Karl
Karl.1
4 yrs ago
Rapamycin Discussion
Reported - view
Re: Rapamycin Cost
@Van you may be correct in your n of 1, but to generalize would be erroneous. Saying that dosing is easy for a drug used for unapproved indication, that has not been adequately studied in humans for…
Karl
Karl.1
4 yrs ago
2
Self-Experimentation
Reported - view
Re: Intermittent fasting and rapamycin
I doubt there have been adequate human studies on either Rapamycin or Fasting, let alone all the various IF regiments and how they interact with Rapamycin.…
Karl
Karl.1
4 yrs ago
General Discussion
Reported - view
Re: Toniq Resveratrol?
Actually it “Toniiq” with two i’s
Karl
Karl.1
4 yrs ago
Questions & Answers
Reported - view
Toniq Resveratrol?
Does anyone have information on quality of brand “Toniq”? They sell a Resveratrol that is higher dose than many others.
Karl
Karl.1
4 yrs ago
1
reply
49
Questions & Answers
Re: NAD and Statins?
Doubt there would be an interaction, but no way to get a definite answer as it isn’t a drug, and hasn’t been a supplement very long.
Karl
Karl.1
4 yrs ago
General Discussion
Reported - view
Re: NUCHIDO
@Garnett Faulkner what is source of nad nasal spray
Karl
Karl.1
4 yrs ago
1
NAD+ Restoration
Reported - view
Re: Rapamycin vs Metformin
@Staffan Olsson great article. Challenging to find these compounds in available supplements. Would like to find a Withaferin A only supplement.
Karl
Karl.1
4 yrs ago
AMPK Activation
Reported - view
Re: Should you get a micronutrient test?
For micronutrients, do you know How they determined “normal” values?
Karl
Karl.1
4 yrs ago
Self-Experimentation
Reported - view
Re: Details of dasatinib + quercetin study
@Paul Beauchemin I think there was also one with 50 D and 500 Q x 5 days.
Karl
Karl.1
4 yrs ago
Senolytics Discussion
Reported - view
Re: Bill Faloon's Recent Blood Test Results
Not sure what to make of this data without baseline data. What would results be without the supplements? Does Bill just have good Genes?
Karl
Karl.1
4 yrs ago
Test Results Discussions
Reported - view
Re: Rapamycin Cost
@Mark Thimineur that is the problem with all of this - insufficient data.
Karl
Karl.1
4 yrs ago
1
Self-Experimentation
Reported - view
Re: Rapamycin Cost
@Mark Thimineur are you saying Dr Green is taking 15 mg (.2 mg/kg)? Are basing this on actual weight or lean body mass?
Karl
Karl.1
4 yrs ago
Self-Experimentation
Reported - view
Re: Kaufmann Protocol Analysis
I have not read her book, but have gone through the website. I think her choice of supplements is a bit arbitrary, with key supplements as you mentioned missing.…
Karl
Karl.1
4 yrs ago
1
Self-Experimentation
Reported - view
Re: Lisinopril and Self Experimentation.
Epocrates is a great website and app for looking up drug interactions. No interactions listed for Lisinopril with either Metformin or dasatanib.
Karl
Karl.1
4 yrs ago
Self-Experimentation
Reported - view
Re: Key Studies and Articles
@Larry Thanks finding that study. She also states on website that Quercetin is the ONLY otc senolytic which is wrong - Fisetin, Curcumin and others.
Karl
Karl.1
4 yrs ago
General Discussion
Reported - view
Re: Key Studies and Articles
Kaufmann paper on senolytics https://static1.squarespace.com/static/5aac3477f8370a964b2550c7/t/5d91091dbd027f6ecf806f8f/1569786142074/Senescent+Cells+%26+Senolytic+Therapy.pdf
Karl
Karl.1
4 yrs ago
2
General Discussion
Reported - view
Re: Rapamycin Cost
@Ellis Toussier book idea sounds great.
Karl
Karl.1
4 yrs ago
Self-Experimentation
Reported - view
Re: Rapamycin Cost
@Steve Roedde that is a great find assuming there are no significant contaminants. Several other interesting products they sell. I’m always a bit leery of Chinese and Indian products.
Karl
Karl.1
4 yrs ago
1
Self-Experimentation
Reported - view
Re: Rapamycin Cost
@Steve Roedde are you saying that you did get legitimate Rapamycin?
Karl
Karl.1
4 yrs ago
Self-Experimentation
Reported - view
Re: Intro to rapamycin
@Sanford Finley regular feedback will be greatly appreciated. Good luck.
Karl
Karl.1
4 yrs ago
1
Rapamycin Discussion
Reported - view
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Karl
Karl.1
Arizona
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Joined: Wed Dec 04 22:14:27 UTC 2019
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