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Re: Resveratrol -- value, dose, source?
@JGC Do plasma levels correspond with intracellular levels I wonder?
- Karl.1
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Medical Research
I’ll agree and disagree with you. Unfortunately a lot of that research investment goes towards specific treatments that can be patented and give a return on investment even if they don’t change the…
- Karl.1
- 5 yrs ago
- General Discussion
- Reported - view
Key Studies and Articles

As I come across them I will edit this post and list important references to have them in one location. Blagosklonny Article on Rapalogs https://www.ncbi.nlm.nih.…
- Karl.1
- updated 5 yrs ago
- 5replies
- 134
- 2
- General Discussion
Re: Resveratrol -- value, dose, source?
I’ve been using Pure Encapsulations Resveritrol, but thinking about switching to Pterostilbene since it may be better?
- Karl.1
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Mechanism for Immortality
@Chan agree that a lot of this is a “fad” at this point. I’m not impressed by the data so far on NR/NMN. I’m thinking long term answer is DNA therapy and telomere therapy.…
- Karl.1
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Intro to rapamycin
@Aaron Lahm It is unlikely that you will find, unless you specifically search for, a doctor that is up to speed on anti-aging therapy, and Rapamycin use.…
- Karl.1
- 5 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Rapamycin self-experimentation
@Mark Thimineur Thanks for all the info, and thanks for what you do. Pain management must be one of the most challenging specialties in medicine.
- Karl.1
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Rapamycin self-experimentation
@Mark Thimineur 1. I’m having trouble coming up with a mechanism by which rapamycin would treat psychiatric illness. Any ideas? 2. How much concern do you have about malpractice using a powerful…
- Karl.1
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Mechanism for Immortality
So, anybody that meditates will live to be 120? Meditation may be great for your health, but you'll need more than that.
- Karl.1
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Rapamycin - What age is "too young?"
I would think that the hesitation to promote Rapamycin in young people is that we just don't have the data on the long term risks. It may benefit you, but what will taking this drug for 20 or 30…
- Karl.1
- 5 yrs ago
- General Discussion
- Reported - view
Re: Is metform safe to take for non-diabetics?
"Is it safe" is not really the correct question to ask. The better question is "do the benefits outweigh the risks?" The answer depends on a lot of personal factors.
- Karl.1
- 5 yrs ago
- Questions & Answers
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
Thanks for sharing your experience. Sounds like great results. Now, if only we knew what happens after you do this for 10-20 yrs.
- Karl.1
- 5 yrs ago
- Senolytics Discussion
- Reported - view
Re: Paul's self experimentation
So you started the Metformin to treat the cancer, not because you’re diabetic?
- Karl.1
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Introduction to NAD+
an Interesting study in Humans that seems to show NAD+ does not decline with age, and questions whether NR supplements do much. Especially interesting since one of the investigators works for…
- Karl.1
- 5 yrs ago
- NAD+ Restoration
- Reported - view
Re: A different point of view
Seems like there should be a section on this forum dealing with Telomere therapy, and Telemorase activiation
- Karl.1
- 5 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism
A concerning result. Questions would include does this worm study correlate to humans? What is “old age” in a human compared to a worm? Maybe this study reinforces the importance of senolytics.
- Karl.1
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Sources of dasatinib
@GEdwards thanks for all the info. Good luck with your senolytic Armageddon. The problem with many of these drugs and supplements is that human dosing is mostly unknown.
- Karl.1
- 5 yrs ago
- Senolytics Discussion
- Reported - view
Re: Sources of dasatinib
@are we there yet so not FDA approved or for sale yet?
- Karl.1
- 5 yrs ago
- Senolytics Discussion
- Reported - view
Re: Power a Longer Life via NAD+ Restoration
Is this statement from a study?
- Karl.1
- 5 yrs ago
- NAD+ Restoration
- Reported - view
Re: Interesting book
Another interesting book. Most of this one is free read online. First chapter gives a good scientific evaluation of longevity substances. Anti-aging drugs https://books.google.…
- Karl.1
- 5 yrs ago
- General Discussion
- Reported - view
List of important articles, books, and websites

Does such a list exist on this website? If not, shouldn’t there be one?
- Karl.1
- 5 yrs ago
- 1reply
- 59
- 1
- Questions & Answers
Interesting book

Biochemistry and Cell Biology of Ageing https://books.google.com/books?id=cs2NDwAAQBAJ&pg=PA339&lpg=PA339&dq=Chapter+13%0AHealth+Benefits+of+Anti-aging+Drugs%0AVeronika+Piskovatska,+Olha+Strilbytska,…
- Karl.1
- updated 5 yrs ago
- 1reply
- 71
- 1
- General Discussion
Re: 32 years old. Is self-experimentation right for me?
Strongly agree with Dan. At your age, concentrate on healthy lifestyle. You are fortunate to have time to wait for more research to get done.
- Karl.1
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Green tea and green tea extracts
@Dan the term “hormesis “ does not mean “cycling”. But rather is a biphasic response. But you are correct that a stress response may be very important in the prevention of aging.…
- Karl.1
- 5 yrs ago
- Self-Experimentation
- Reported - view
Sulfuraphane

On Dr Kaufmann’s website, it states that sulfuraphane protects cells from apoptosis and senescence. This would seem to work against senolytics. Does anyone take sulfuraphane and if so do you stop…
- Karl.1
- 5 yrs ago
- 1reply
- 213
- 1
- Senolytics Discussion

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