Rapamycin - What age is "too young?"
Hi everyone,
I've read various posts in this forum over the past year and I've become very interested in Rapamycin. I am a very physically fit 40 year old and have a love affair with both weight lifting and running. I have very low body fat and follow a good diet, avoiding junk food, soda, etc. Basically, I am in excellent health.
That said, I have a very strong family history of both cancer and Alzheimer's. I've read that there is a strong correlation between intermittent rap and avoiding those two diseases. The problem is, I can't find any definitive information about how soon is "too soon" to take it. I found one comment by Dr. Green from back in 2016 saying that 42 was too young for someone to take it, but I can't find the reasoning behind that. My thought here is that its probably easier to prevent senescent cell formation than it is to get rid of them.
Can anyone shed any light on this?
Thanks!
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I think I'd shoot an e-mail off to Dr. Green at alangreen225@gmail.com. He's very good about answering e-mails, and he began taking rapa at 70, I believe. I have friends in their 40's who are interested in when to start as well.
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Gavril Villiamovich I actually did just that. Dr. Green asked that I get a 23andme run to see if I have the APOE4 gene before I meet with him, but whether it's there or not, he thinks that Rapamyin would help me slow down the aging process, even at 40. The logic seems pretty simple to me (though I doubt it's really this easy): if it's an effective senolytic, it's probably easier to slow down aging starting now than it is to try to repair it later.
I'm in the process of setting up an appointment in December. I will post back here to let everyone know how it goes. -
Nick how did it go? and pardon my ignorance, I’m fairly new to Rapamycin, would you mind sharing why the Dr. asked about the APOE4 gene, I have my 23andMe on the way.
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Frank Cordero it went well! Ive been doing 3mg once per week for 5 or 6 weeks now. No body parts have fallen off yet so that's a plus :-)
Jokes aside, I dont really feel any different. No side effects, no increase in energy levels, but I didnt really expect or need that since I'm in excellent shape for my age.
With the script from Dr Green and my insurance, I'm only paying $10 per month for the Rapamycin. That was a pleasant shock! If anything changes, I'll drop back in.
Side note, Dr Green is a pretty great guy. It was nice just to converse with someone who's interested and highly educated in this topic as well.
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I would think that the hesitation to promote Rapamycin in young people is that we just don't have the data on the long term risks. It may benefit you, but what will taking this drug for 20 or 30 years do? Is it worth the risk. Nobody really knows yet.
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Karl Well, I'm hoping I can take it for at least another 20 years. 😄
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I’m thinking of beginning rapamycin and like the 40-year-old I’m also in very good physical condition and I’m wondering if anyone who is in excellent condition has started the program and noticed any effects? Also I am 70 years old so I’m going to try it but I have been taking HGH for the last 13 years and thought it was very beneficial. Has anyone taken HGH with rapamycin?
I did read an interesting article which implied HGH could be beneficial because it promotes MTOR2 and rapamycin suppresses MTOR1.https://www.fightaging.org/archives/2018/02/rapamycin-does-not-interact-favorably-with-growth-hormone-receptor-knockout/
