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Re: Stopping Metformin
@John Hemming have you compared on Berberine and off Berberine on your monitor?
- Karl.1
- 3 yrs ago
- AMPK Activation
- Reported - view
Re: Canagliflozin - A One Month Report, Its Good
@David interesting. Goes against most other studies and antibiograms. https://journals.asm.org/doi/10.1128/AAC.00862-20 I would not give Cipro to anyone unless it was last resort because of its…
- Karl.1
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Canagliflozin - A One Month Report, Its Good
@David remarkably unlikely to happen in anyone not using insulin.
- Karl.1
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Dr Green new Rapamycin high dose
@Mark Thimineur are you aware of any comparisons between the cream you make and commercially available Tacrolimus cream?
- Karl.1
- 3 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Canagliflozin - A One Month Report, Its Good
@Geoff Welch are you sure that Dr Attia is taking it himself?
- Karl.1
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Canagliflozin - A One Month Report, Its Good
Thanks for bringing up the topic and including references
- Karl.1
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Canagliflozin - A One Month Report, Its Good
@David Bactria and Cipro, although both commonly prescribed for UTI’s, have a 20-30% failure rate due to bacterial resistance.
- Karl.1
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Stopping Metformin
@Brian Valerie interesting. I’ve thought of Berberine as similar to Metformin enough that I’m stopping Berberine.
- Karl.1
- 3 yrs ago
- 1
- AMPK Activation
- Reported - view
Re: Stopping Metformin
@Karl https://diabetesjournals.org/care/article/44/12/2775/138471/Effect-of-Metformin-and-Lifestyle-Interventions-on
- Karl.1
- 3 yrs ago
- 1
- AMPK Activation
- Reported - view
Re: Stopping Metformin
https://www.fightaging.org/archives/2021/09/metformin-remains-a-poor-choice-in-the-treatment-of-aging/
- Karl.1
- 3 yrs ago
- 1
- AMPK Activation
- Reported - view
Stopping Metformin

Has anyone stopped taking Metformin as recent literature suggests it may not be of much benefit in non diabetics?
- Karl.1
- 3 yrs ago
- 20replies
- 473
- 1
- AMPK Activation
Re: I Want to be a Rapamycin Doctor!
@JOHN did you sign any paperwork indicating that you understood the medications were not being given for their approved purpose or anything like that?
- Karl.1
- 3 yrs ago
- General Discussion
- Reported - view
Re: I Want to be a Rapamycin Doctor!
@SCOTT WEANER I’ve also considered it as a side gig, as people such as those on this board need physicians they can get help from, but the malpractice side of it is a big concern.
- Karl.1
- 3 yrs ago
- General Discussion
- Reported - view
Re: PCC1 is senolytic and senomorphic
If using it as a senolytic I’d think you’d want to cycle it.
- Karl.1
- 3 yrs ago
- Senolytics Discussion
- Reported - view
Re: I Want to be a Rapamycin Doctor!
Scott; website looks interesting. As a fellow physician, I’m interested in what you are doing about malpractice. Clearly this is on the fringe of standard medical practice.…
- Karl.1
- 3 yrs ago
- General Discussion
- Reported - view
Re: metformin negative study
Aren’t there human studies that would outweigh a single worm study?
- Karl.1
- 3 yrs ago
- General Discussion
- Reported - view
Re: The Science on Rapamycin for Skin - 2 papers - Your Thoughts?
Has anyone compared Rapamycin on skin to the available Tacrilimus skin ointment?
- Karl.1
- 3 yrs ago
- Rapamycin Discussion
- Reported - view
Re: A 5 minute test for rapamycin
Is there an optimal level for Rapamycin?
- Karl.1
- 3 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Recent Plasma-Replacement Results
Too bad this topic doesn’t get more attention.
- Karl.1
- 3 yrs ago
- Young Plasma Infusions
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
After taking NMN for a couple months, I have stopped for the following reasons. 1. There appears to be little evidence that it actually gets into your cells to any significant degree. 2.…
- Karl.1
- 3 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Harold Katcher and the 50% younger mouse
Surprised there is so little talk here about Katcher’s work
- Karl.1
- 3 yrs ago
- General Discussion
- Reported - view
Re: 'Mandated Gov Vax or get fired' I'm one of them. Which one is the least toxic in the long run to our longevity path..? Thanks
@Dan Nave In regards to “side effects “ of the vaccine, the rate is 5-10 fold worse with the infection.
- Karl.1
- 3 yrs ago
- General Discussion
- Reported - view
Re: IVERMECTIN/PROPHYLACTIC DOCTOR FLORIDA
@David H a little chip on your shoulder?
- Karl.1
- 3 yrs ago
- General Discussion
- Reported - view
Re: IVERMECTIN/PROPHYLACTIC DOCTOR FLORIDA
@Fred Cloud a somewhat odd question. I won’t be on my death bed from Covid because I have already received proven treatment. 3 doses of Pfizer vaccine.…
- Karl.1
- 3 yrs ago
- General Discussion
- Reported - view
Re: IVERMECTIN/PROPHYLACTIC DOCTOR FLORIDA
@David H Respectable studies are underway in both The U.K. And U.S. to look at Ivermectin. We’ll see if it works or is another Hydroxychloroquine?
- Karl.1
- 3 yrs ago
- General Discussion
- Reported - view

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