Yes, for that reason I've cut back, but although I'm not prediabetic my glucose is consistently high. I've ordered some empagliflozin in hopes that will bring it into normal range so I can reduce it further but I doubt I will eliminate it altogether. As a side note, since cutting back the metformin I've been able to gain some wanted weight.
I was about to start metformin, but decided that berberine (along with milk thistle extract) was a better alternative. I agree with you that the evidence thus far does not justify use of metformin by most non-diabetics. Many pre-diabetics, however, may indeed benefit, and should certainly discuss the issue with their doctor.
I am not sure about the analysis in the recent report on Metformin. I have been taking Berberine. I have not noticed any effect.
Recently I implanted a Continuous Glucose Monitor. That has confirmed that I am neither diabetic nor pre-diabetic. However, I don't know what it would have said had I not taken some Berberine. I would not be surprised if in fact it is insufficiently bioavailable to have any effect, but I am busy doing a lot of other experimentation and have not really got the time to try to check out the effects of Berberine.
Berberine may help with cholestorol.
Well I have six days of data that is comparable. The first two days I took 1 capsule of Berberine at 8.30am, the second two days I took none and the third two days I took 2 capsules of Berberine at 8.30am.
I have not included the other days of the session because I only calibrated the CGM part way through and it was adjusted by about 2 mmol/l. That makes those readings not comparable. I did not calibrate the CGM during this period because I am not sure that calibration is that consistent and hence I preferred to have comparable relatively data rather than data that might have been more reliable on an absolute basis.
If anything the blood sugar was lower on days I didn't take Berberine, but I have not tried to control that many variables and I would say that the results were not conclusive. My breakfast is consistent and my lunch is also consistent. At times I walk rapidly to my office which takes the blood sugar temporarily down. I am drinking alcohol most nights, varying amounts. My dinner varies, but I avoid high GI foods and don't eat a lot of carbs. I often go to sleep between 9 and 10pm.
The precision of the CGM is 0.1 mmol/l and I do have a CSV file of the results. I am quite irritated by the difficulty of making Excel behave for charts so I am thinking of writing a java program to report on heart rate and blood sugar as well as other things. However, I know that will take me a few hours so I have not done it yet.
I have now ended this CGM session. I will do another session of 10 days in the future, but not immediately as I want to think carefully about how best to structure the session in terms of foods/supplements etc.
I must admit that I find the data quite interesting. All I have had previously is random blood sugar tests (the most recent of which was 3.5 mmol/l and an HbA1c which was 30 mmol/mol. Those were May last year, but are not inconsistent with these results.
I have found this which looks at Berberine evidence
It appears that Berberine reduces blood sugar for people with diabetes. (type 2) I am not sure, however, what information there is about Berberine for people who are not diabetic.
The review I link to does give good reasons for continuing Berberine, however.