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Re: rapamycin cream @Bruce B dissolved 6mg rapa (from capsules) into 10ml of transcutol (stirred x 1 hour in magnetic stirrer per the study), then mixed 5ml into each of two 4-ounce jars of Cerave lotion.…
- David
- Davin8r
- 2 yrs ago
- Rapamycin Discussion
- Reported - view
Re: rapamycin cream @Bruce B also, what about adding fisetin and giving the cream a potential senescent cell-clearing effect? At least in theory, rapamycin+fisetin should be an amazing one-two punch.
- David
- Davin8r
- 2 yrs ago
- Rapamycin Discussion
- Reported - view
Re: rapamycin cream Thanks Bruce! I just ordered some transcutol from lotioncrafter.com for $20 for 8 ounces (including tax and priority mail shipping). Right now I'm using a rapamycin lotion I made by extracting 6mg…
- David
- Davin8r
- 2 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Stopping Metformin @John Hemming I also noticed what seemed like significantly higher blood glucose readings on my CGM while I was still taking berberine (500mg three times daily).…
- David
- Davin8r
- 2 yrs ago
- AMPK Activation
- Reported - view
Re: Stopping Metformin @MAC. If DHB also inhibits 3A4 like berberine (I haven't seen any studies, so maybe maybe not?), but if it does, then yes it would increase the AUC and delay clearance by the liver,…
- David
- Davin8r
- 2 yrs ago
- AMPK Activation
- Reported - view
Re: Canagliflozin - A One Month Report, Its Good @Karl I don't like cipro either (tendon rupture makes me cringe just thinking about it) and Bactrim can also cause nasty allergic reactions as a sulfa drug.…
- David
- Davin8r
- 2 yrs ago
- Self-Experimentation
- Reported - view
Re: Stopping Metformin Reference for berberine/metformin inhibition of mitochondrial complex I: https://pubmed.ncbi.nlm.nih.gov/29106036/ Berberine and cytochrome p450 inhibition: https://pubmed.ncbi.nlm.nih.gov/21870106/
- David
- Davin8r
- 2 yrs ago
- AMPK Activation
- Reported - view
Re: Dr Green new Rapamycin high dose Sorry never mind, I searched the forum and found where you posted rapa cream recipe previously. Since I'm hesitant to apply DMSO to my skin and I want the rapa to stay *in* my skin rather than be…
- David
- Davin8r
- 2 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Stopping Metformin @MAC. I'm very familiar with the research on berberine and its multitude of potential health benefits, but it does inhibit mitochondrial complex 1, and therefore could inhibit adaptations to…
- David
- Davin8r
- 2 yrs ago
- AMPK Activation
- Reported - view
Re: Dr Green new Rapamycin high dose @Mark Thimineur would you mind sharing the % DMSO in the cream you use? I see a 4 oz cream with 70% DMSO/30% aloe in a cream base available online, for instance. Thanks!
- David
- Davin8r
- 2 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Stopping Metformin @Brian Valerie I too stopped berberine, given that it in theory should inhibit positive adaptations to exercise just as metformin appears to do. It also has quite a few potential drug interactions,…
- David
- Davin8r
- 2 yrs ago
- 1
- AMPK Activation
- Reported - view
Re: Canagliflozin - A One Month Report, Its Good @Karl time will tell
- David
- Davin8r
- 2 yrs ago
- Self-Experimentation
- Reported - view
Re: Canagliflozin - A One Month Report, Its Good @Karl only 1.9% resistance to Cipro in this study from 2017 although certainly is on the rise: https://pubmed.ncbi.nlm.nih.gov/27234045/
- David
- Davin8r
- 2 yrs ago
- Self-Experimentation
- Reported - view
Re: Canagliflozin - A One Month Report, Its Good The side effect I'd be most concerned about from combo SGLT2 inhibitor and rapamycin is bacterial infection, specifically UTI. Dr. Alan Green (rapa guru in NY) just posted an Oct 2021 update saying…
- David
- Davin8r
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Canagliflozin - A One Month Report, Its Good Just did some reading on case reports in the literature involving euglycemic type 2 diabetic ketoacidosis in patients taking canagliflozin. Sounds like DKA is most risky in type 1 diabetics (unable…
- David
- Davin8r
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Canagliflozin - A One Month Report, Its Good @Geoff Welch Did you mean to address your question to the original poster (Brin)? Regarding your question, what exactly is your concern about insulin + ketones in non-diabetics? Ketoacidosis?
- David
- Davin8r
- 3 yrs ago
- Self-Experimentation
- Reported - view
Source of pyridoxamine?
Anybody have a source of pyridoxamine for anti-glycation self-experimentation? It is still sold in Europe as a supplement, but was banned in USA since it's being developed as a drug. Thanks
- David
- Davin8r
- 3 yrs ago
- 27
- Self-Experimentation
Re: Normalized Nitric oxide, Citrulline and a youthful endothelial function. HBOT has had some extremely promising new studies lately. If only it were more accessible!
- David
- Davin8r
- 3 yrs ago
- General Discussion
- Reported - view
Re: Weekly rapamycin and protein/resistance training regimen @Staffan Olsson Interesting, but I wonder if by activating proteins downstream of mTOR, citrulline might also block some of the beneficial effects of rapamycin?
- David
- Davin8r
- 3 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Weekly rapamycin and protein/resistance training regimen Thanks! I'll try @Blagosklonny. Even though the drug has a long half-life, when we're dosing it weekly it's still down to 1/2 concentration in about 2 or 2.…
- David
- Davin8r
- 3 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Rapamycin Physicians in the SF Bay Area? You could do a telemedicine appt with Dr. Jerry Morris (he's in Texas, but does rapamycin therapy and specializes in anti-aging medicine and prescribes out of state). Jerry W.…
- David
- Davin8r
- 3 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Any recommendations on Rapamycin prescribing doctors either via Telemedicine or close to Chicago or Miami? Jerry Morris, DO in Texas. Just had a telemed appt with him last week (total cost of $275 for the appt, but we talked for a good 45 min). He does rapa therapy and also has options for all kinds of…
- David
- Davin8r
- 3 yrs ago
- General Discussion
- Reported - view
Re: Canagliflozin - A One Month Report, Its Good Actually the discussion of canagliflozin doesn't start until about 1 hour 50 minutes into that Peter Attia video (but thanks for the link!)
- David
- Davin8r
- 3 yrs ago
- Self-Experimentation
- Reported - view
Weekly rapamycin and protein/resistance training regimen
Hi everyone, I'm planning to start my first dose this weekend (50 yo male) and have been wondering something that I've never seen addressed by the gurus.…
- David
- Davin8r
- 3 yrs ago
- 6replies
- 380
- 1
- Rapamycin Discussion

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