Fisetin experimentation one year (reposted as topic for info purposes)

Dean W. My body weight is 104 kg. I take 30 capsules = 3g a day for three days straight. Fisetin is fairly safe, you'd really have to take an enormous amount to do any damage. Mice models were taking way way up there. No ill effects. I started taking 1.8g and then moved to 3g. Zero issues. 

So take whatever you feel comfortable with. And move up if you like. 1.5g is not bad for 70g weight. It's actually pretty consistent with how I calculated back when I first started. 

I have found repeating every 3-4 weeks is the ideal time. 

Brian Valerie Well, for myself personally I just keep taking what I know works. The bioavailable versions are probably just as good but then you have to trust their calculations on whether or not it works and at what dosage. I like plain fisetin because the mouse studies used this and we can translate dosage to humans fairly easily.

Quercetin is very closely related to fisetin in its chemical structure. So I "hypothesize" that its mechanism of action is similar and it probably acts on the same pathway as fisetin. And we know that fisetin alone was much more potent that quercetin (studies have shown). So I never saw the need to replace fisetin with quercetin even in a mix and match scenario because it's almost like mixing in a weaker version of fisetin with full strength fisetin. Now this could be completely wrong and I even bought quercetin at one point. The real problem is it gets expensive when you add in other items and for the reason mentioned above I just felt quercetin was doing more of the same, just poorly.  

If memory serves me right in the mouse studies they did essentially the equivalent of 3g (for your weight 84kg) a day for two days then waited like two to three weeks and repeated. Now no one knows the real effects or optimal dosage and frequency but I also still notice increased energy, clarity, muscular firmness, and less inflammation around the neck and face. Almost as if my face is at rest from something always agitating it and attacking it at a low level. These positive effects last for 3 weeks on average and then I think about doing another round of fisetin.

For some of the others asking if I still get positive effects, yes I do. But my baseline has raised significantly so its a less glaring improvement than from the first time I used it. Indicating some level of permanent effects took place. I believe fisetin is both a senolytic and senomorphic compound. That is to say it both causes apoptosis in senescent cells and suppresses SASP (the harmful signaling from senescent cells).

This means fisetin both kills a portion of senescent cells and can disrupt the ones it does not kill outright so that for a time they don't emit SASP. This would explain my experience with fisetin if so. Keep in mind I am no scientist, but even scientists don't have all the answers as we have yet to really have a human study with fisetin although I hear one is ongoing now. 

Dean W. I still get the same effects. The benefits last for two weeks steady and then wane during week three. By the end of week three I plan for my next dosage. I can occur immediately at three weeks or even a week later. 

I have tried to explain how it works/worked for me. The initial dosing way back when was very effective. My baseline was low. Low energy, fatigue, malaise, and so on. After I took my first round of fisetin my entire energy spectrum changed. I felt I could see colors more vividly, hear sounds more acutely, and had increased strength and muscle firmness all over. I could also stay up till the wee hours of night without getting tired. 

All of these things did not go away. Alot of it remains permanent. So now when I take fisetin its more of a maintenance effect, however I still get heightened benefits as listed above but the difference is not as stark as my baseline has been raised overall.

This is my experience with it. I also gave some to a friend who is 37 years old. It was funny because the guy was running around doing house projects for days. A person that usually lays on the couch after work defeated and plays on his phone or watches TV. He had so much energy and drive he could not contain it. He also noticed muscle firmness. 

Chris  yes it was like this for me my first time especially. So on day 3 or so things should be better. I slept a lot and by about day 3 is when I realized it had really kicked in.

If you were knocking out 25 to 50% of senescent cells in tissues it might mean the body would like to rebuild and restructure. Not only to replace those cells but now the environment for cell replication and restoration would me much more free of SASP which hinders maintenance. In other words your body has a lot to do, and suddenly.

Now when I take it I don’t get that same fatigue as when I first did it. Pay attention to leg strength. It’s the first sign I had that this was doing something beneficial. You should get boosts of energy, increased mood, and muscle firming if it’s like me. Give it a day or so then just go for a walk. I had increased perception and presence in the world. Good energy and impressive leg strength. Like hills that would make me groan were fun to just bounce over.

Chris Well I recently added NMN to the whole regime. I am careful not to add too much because then it becomes to costly and I am afraid there will be interactions that nobody has forseen.

I hope it works well for you. At the very least it's a harmless regimen. It has proven results in the lab and I really love the stuff.

If you do notice increased muscle density, energy, mood, and all the other stuff it usually lasts like 2 weeks solid and then by week 3 it normalizes a bit and then I let it go another week and repeat. You could possibly do it more often than 4 weeks. At 3 weeks I think its fine. I tried it every 2 weeks and had some scalp itching so I went back to every 4 weeks.

The thing is, if this does increase testosterone levels it does it via your own body's functions. Because the bioavailability is fairly fast. It should be out of your system in like 12 hours for each does. So it's not like a steroid that adds literally the hormone itself it only encourages production of testosterone via your own body's functions. That is if indeed it does increase hormone levels. But it should be safe even if it does because you should theoretically be getting testosterone meant for your specific body.

The main use of this stuff is to clear senescent cells. Just like you I was tired at first, I just slept alot and it goes away. I think your first run through will clear out the vast majority of senescent cells that fisetin is able to eliminate which would cause some fatigue as the body has some restructuring to do afterwards.

But later on when you are doing repeat doses monthly it's just a maintenance dose and there is just not as many senescent cells to clear, meaning really no fatigue. 

Glad to see you are trying it out. Human studies do I think next month on this. So we will have a little more data to go off soon.