GlyNAC
Has anyone tried Glycine/N-acetylcysteine? It appears to have amazing effects on age reversal.
Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial
https://onlinelibrary.wiley.com/doi/epdf/10.1002/ctm2.372
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That's very interesting. The only source that I see online seems to be Celltrient. They sell 112 x 600 mg + 600 gm caps, taken 2/day, for $60.79. However, I see that Life Extension sells Glycine ($9.00 for 100 x 1000 mg caps) and N‐acetylcysteine ($10.50 for 60 x 600 mg caps) as separate supplements. I think that works out to be around 1/2 the Celltrident price.
Perhaps it's worth it, but I think I'll wait for others to report any age reversal observations after taking this supplement. It would be nice if someone would determine their Horvath DNAm age before and after taking a month or so of GlyNAC supplements.
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JGC I don't see the point of overpaying for a designer product if we are talking about simple amino acids.
Just buying their Ajipure version is sufficient if one is concerned about quality.
What I am more concerned about is the large NAC dose which is reported to cause PAH.
Personally, I would stick to max 1800mg /d NAC and 5g/d Glycine and call it a day.
If it helps with boosting GSH to youthful levels, good. If it's insufficient, it is still better than nothing and I am fine with that.
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aribadabar Your concern is that PAH causes cancer? Will NAC be transformed to PAH in the body? Do you have a reference?
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Qimin You PAH= Pulmonary arterial hypertension.
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aribadabar OK, I thought it was Polycyclic Aromatic Hydrocarbon
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aribadabar I read a study that NAC prevents PAH. Link here:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996671/
What is your source that it causes PAH?
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The study quoted above indicates that the GlyNAC benefits go away when the supplement is halted. That suggests that no epigenetic reprogramming has been achieved.
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JGC I am 55kg, so I should take abut 5g/day. But I think it will be safer to take less, say 2g of each to start with. there is not much data about GlyNAC help epigenetic reprogramming. I searched MEDPUB, and found all related publications are from the same Lab. So...
But I think at least they shall be safe, they are only amino acids...
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I just calculated the dosage of the GlyNAC supplements that was used in the Baylor Med study. They say that they administered glycine (1.33 mmol/kg/day) and cysteine (0.81 mmol/kg/day). That means they would give a subject weighing 70 kg about 7,000 mg/day (7 g/day) of both Glycine and N-acetylcysteine. That would mean one would have to take a lot of caps per day. The dosage recommended on the Celltrident bottle is only 1.2 g/day. One would go through a "$60.79 - 1 month supply" on about 5 days.
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JGC I have been taking it at 2 caps twice a day for around 2 months and I feel more relaxed. I am considering just taking the two separate, as there is no indication of the two being bound in any way in the Cell Nutrient form.
Glycine’s daily intake for me in the past was closer to 5g a day while I had no experience with NAC, so the recommended 2400mg would likely work.
if I buy the two separate, just a quick search on Amazon, NOW supplements has 250 capsules of 600mg NAC for less than $19. (2 months) and the Double Wood has a bottle of 300 capsules of 1000mg glycine for less than $20. (2 months 15 days at 4G a day)
I have used both these brands.
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Does anyone know any details of the timing of the dosage? All before bed? Spread out over the day? I've been taking NAC (600mg) before bed for a while. Going to 7g or 9g seems like a lot. I might schedule a follow up with Dr. Green - just to discuss this.
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Andrew
The Baylor Med paper says that the 8 old (71-80) and the 8 young (21-30) participants were given prepared capsules containing the GlyNAC dosages, and they were checked periodically to make sure they were taking them. There is no information in the paper about when they were told to take them (if they were) but it sounds like they took one big dose (in the capsule) at a time of their own choosing.
Following Aribadabar's suggestion, I searched on Aijpure and found that Swanson has Glycine for $2.99 for 60 x 500 mg caps and N‐acetylcysteine for $6.39 for 100 x 600 mg caps. That's rather better than the LE prices.
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JGC I found glycine at 22 $ for 1 kg.
Glycine Powder | Amino Acid Supplement | Nonessential Amino Acid — BulkSupplements.com
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Staffan Olsson
BulkSupplements.com also sells NAC powder, but it's a bit more expensive: $50/kg.
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Andrew I’m a patient of Dr. Green as well. I just emailed him the same question. Did he get back to you. Is it to be taken everyday at 7 and 9 grams?
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Benjamin Schoolman - in response to my questions regarding senolytics and GlyNac - he replied "If you would like to discuss this in further detail, please schedule a consultation"
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JGC There is a bulk powder version of Ajipure Glycine too.
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JGC Also, your link points to the non-Ajipure NAC offering. The correct one is a more expensive but not terribly more so.
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Why all this capsule talk when you can buy bulk powder. Mix it with something into a drink. I haven't tried it but sounds like it might work.
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Allen Glycine is very pleasant but cysteine isn't. You need to overwhelm it with something sweet and dilute substantially.
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aribadabar Thanks for the info. I have nac capsules and opened one up after reading your post. You're right, it's really strong. I had no idea it was that bad.
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yikes, just tried a gram of NAC powder in my shake and taste is incredibly bad.Not sure how to overwhelm it to get it down
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Paul Beauchemin Yeah, its nasty. I just stick with capsules. You can get a big bottle pretty cheap on amazon.
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These dosages seem very high. However, as Dr Green points out below it's the amount that is found in a large steak. I calculated for me as a 90 kg male it would cost me about $75 dollars per month to take this large dose of both supplements. Hopefully Dr. Green has his compounding pharmacy on the case. My wife has her annual appointment with Dr Green next week so she will discuss the new protocol. Dr Green's website talks about adding this regimen to his anti-aging protocol. I already take 600mg/day of the NAC. I may add the glycine to this in the morning on an empty stomach. Taking amino acids on an empty stomach is the preferred method. See from Dr Green's website below:
In March 2021, high dose supplementation with amino acids cysteine as NAC and glycine was revealed as an effective treatment for mitochondrial dysfunction and that is now also included in protocol.
Treatment of Aging
A recent paper from Baylor College of Medicine, Houston, March 2021 represents the first great breakthrough in the treatment of aging itself. In 1956 Harman presented his free radical theory of aging. Just 67 years later, that theory has borne fruit. Mitochondria are little batteries that generate chemical energy that provide the energy for life. During the process, mitochondria generate toxic reactive oxygen species (ROS) which cause harmful oxidative stress to mitochondria. The major antioxidant mitochondia depend on for protection against the damaging effects of oxidative stress is GLUTATHIONE. The problem is in older persons, Glutathione levels are at too low a level for protection. This results in mitochondrial dysfunction. Glutathione is composed of three amino acids: glutamic acid, cysteine, and glycine. In older persons the levels of cysteine and glycine are too low to form Glutathione (GSH). The solution to the problem is mind-blowingly simple. Just supply an adequate amount of CYSTEINE AND GLYCINE. The lead researcher, Rajagopal Sekhar, who first published a similar study in 2011; did just that and the results were EXTRAORDINARY. The dose for a 70 kilo man was 9 gram of cystine and 7 grams of glycine (about the amount of these two amino acids in 1.5 pounds of steak).
The results on mitochondrial function, oxidative stress, inflammation, insulin resistance, walking speed, grip strength, cognitive function and other markers of aging dysfunction were remarkable. In a prior study excellent results were seen at 2 weeks. In this study persons were tested at 12 and 24 weeks. By 24 weeks, older persons were showing similar results to young persons in critical areas. Upon stopping treatment, all benefits were gradually lost.
What was different is this study: BOTH Glycine and cysteine (as N-acetyl cysteine (NAC) were administered and in much higher doses.
"Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stree, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial"; Kumar, Sekhar, 2021.
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I would also assume that there were other improvements in the subjects that were not mentioned or yet known. The study was limited by what it could test. Maybe there were improvements in hearing, sight, reaction time, cardiovascular function(ejection fraction), or sleep to name a few.
