GlyNAC

Has anyone tried Glycine/N-acetylcysteine?  It appears to have amazing effects on age reversal. 

Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial
https://onlinelibrary.wiley.com/doi/epdf/10.1002/ctm2.372

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  • I also note this: "Quite intriguingly recent preclinical studies confirmed the pro-tumorigenic and pro-metastatic effects of antioxidant supplementation such as N-acetyl-L-cysteine (NAC), a GSH precursor [155156], thus highlighting the relevance of antioxidants in the protection of cancer cells against oxidative damage. Therefore, antioxidant supplementation can promote the growth of tumors by rescuing the viability of cells under high oxidative stress." https://clintransmed.springeropen.com/articles/10.1186/s40169-016-0106-5 which cites https://www.science.org/doi/10.1126/scitranslmed.3007653 and https://www.science.org/doi/abs/10.1126/scitranslmed.aad3740

    Thoughts?

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    • Jack Black I actually agree with everything you said above and believe the key point is finding the balance.  I have been taking Glynac at a lower dosage (2g each), but every morning as I found that taking it in the evening kept me from sleeping. (But then I am very sensitive re sleep and even eating a burger after 6pm will disrupt my sleep.) I also take rapamycin (currently cut back to 2g once a week as I am trying to find my non-toxic mtor limiting level) as well as a host of other things including resveratrol.  My theory on what to take has been based initially on the statistics of what slows aging and then once I have taken it a while based on how I react to it.

      I would love it if there was a way for all of us to share what we take and why on a regular basis that wasn't public as then we could statistical analysis on all of our experiences.

      Like 1
    • Stevan Lieberman   There are many preclinical studies showing the opposite i.e. beneficial effect of NAC against cancer. But more valid are human studies like this one showing effect of against breast cancer. 

    • Stevan Lieberman here is the link https://pubmed.ncbi.nlm.nih.gov/29248134/

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    • Juan Daw
    • saxxnviolins
    • 1 yr ago
    • Reported - view

    Glycine alone seems to extend lifespan.

     

    As mentioned earlier glycine is the one amino acid studied thus far in which supplementation has been shown to extend the lifespan of mice, albeit moderately [24]. Dietary glycine supplementation also extended the lifespan of Fisher 344 rats through a mechanism mimicking methionine restriction to increase the hepatic clearance of methionine [163]. Glycine supplementation has been show to restore T cell activation, T cell one-carbon metabolism, and mitochondrial function in aged mice [164]. Administration of glycine was also shown to decrease oxidative stress and inflammation by decreasing the levels of advanced glycation endproducts (AGEs) by inducing the expression of glyoxalase 1 [165].

    https://www.sciencedirect.com/science/article/pii/S2468501119300082

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    • Juan Daw Agreed. I think the real question are what substances, in what amounts, when and how do they react to each other. We know lots of things that extend life, but we also know that taken incorrectly could kill us. Here is an article from 2017 which summarizes a long list of them: https://link.springer.com/article/10.1007/s13659-017-0135-9

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    • Karl
    • Karl.1
    • 1 yr ago
    • Reported - view

    I would say the big question is “does anything really extend life in humans?”  Since studies are not done in humans, and it seems almost anything that stresses a worm or fly extends its life by 10%.  I’m taking numerous supplements but I don’t know that any of them are going to help me live longer.  Maybe the Rapamycin.

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    • Karl I take a constellation of substances targeting glutathione production, support of the mitochondria, brain health, folate cycle, skin and joints health, bone strength, and of course Rapa. 

      No idea if this will extend lifespan, however quality of life has improved. My exercise performance is the best it's been in years. My memory is good and cognitive tests are way easier. Skin elasticity has improved by the equivalent of several years.

      In short, whether I live to 95 or not I'm hopeful that my later years will be more active and fulfilling than might otherwise occur.

      Like 1
  • I have been arguing with a friend about hgh.  It seems to me to be too high risk and too little reward based on the literature but he has started on it and says he is feeling better than he has since he was 30.  Anyone with an opinion on hgh? 

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      • Michael
      • Michael.1
      • 1 yr ago
      • Reported - view

      Stevan Lieberman Had the same positive impact on me. There's still a risk profile  however and why CJC and similar peptides are alternatives, esp for older people.

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  • Do you take hgh regularly? and if so for how long? and why did you not go the cjc route instead?

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      • Michael
      • Michael.1
      • 1 yr ago
      • Reported - view

      Stevan Lieberman I started with 1-2 ius daily for 6 months and maxed at 3-4 ius daily for the next 6 months. During one of the second 6 months, I took 6ius daily.

      I then took a serostim break for 3- 6 months while experimenting with peptides: CJC, tb-500, bpc-157, etc... while also trying different versions of gh.

      1. I began using the peptides after doing some more research on the dangers of using exogenous gh, as well seeing an increase in moles  & existing moles becoming darker -  which might have been coincidental. 

      2. I began trying different versions of gh as serostim is so expensive.

      My conclusion is serostim is an awesome product however, depending on your goals and age,  peptides might be just as effective. 

      As an aside, only recently (one year next month) have I begun an elevated version of trt: 300 ml a week of sustanon.

      Testosterone is by far the most efficacious exogenous product I've used. Everything from sleep, strength, focus, gaining size, etc...

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      • Michael
      • Michael.1
      • 1 yr ago
      • Reported - view

      Stevan Lieberman I initially tried gh to mimic Greg Fahys Triim Trial.

      I used Metformin, GH and DHEA to see if it would reduce/reverse my gray hair as it did with one of his participants.  And it worked! 

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      • Jay Orman
      • Jay_Orman
      • 1 yr ago
      • Reported - view

      Michael I suspect that either HGH or Testosterone in some form would give me the benefits of better sleep, mood, and well-being.  And, God knows I certainly do need those things.  However, I've avoided them because I've gotten the impression from what I've read that they would be counter-productive to living a healthier and possibly longer life.  Any thoughts?

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      • Michael
      • Michael.1
      • 1 yr ago
      • Reported - view

      Jay Orman I've read similar things so, I can't say it's not a consideration. I do know     when I turned 50, I started to feel and look old - almost as if a switch was flipped. It was such a drastic and alarming change, I began researching things like those mentioned above and joining forums like this. My conclusion is QUALITY of life is at the moment, as important to me as longevity and the quality of my life has certainly improved.

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      • Jay Orman
      • Jay_Orman
      • 1 yr ago
      • Reported - view

      Michael Yes, I see your point. 

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    • Jay Orman
    • Jay_Orman
    • 1 yr ago
    • Reported - view

    Has anyone following the GlyNac Protocol for 4 to 6 months or longer actually noticed any improvements?  I tried it briefly, but stopped possibly too soon.  

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      • Chris M
      • Chris_M
      • 1 yr ago
      • Reported - view

      Jay Orman Yes, my 75 yo mother has been following it for 2 months and her diabetes factors have decreased by about 10%

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  • I have recently started  GlyNAC supplementation test for myself (59yrs) and my father (85yrs). Prior  to started GlyNAC we were taking an enormous amount of different antiaging supplements some in Liposomes (such as NAD+ boosters), then omegas, berberine, multivitamins etc  for a total of possibly 20 or more supplements per day.

    After I started GlyNAC I immediately noticed unfavorable interactions my existing supplement regime and started removing nearly all supplements (now I have over 1K USD in what could turn into obsolete inventory here at home!).  I feel interactions are reduced but still have some ringing in my ears as a minor side effect. Did anybody else trying GlyNac experience interactions with other supplements ?

    In the trial it is stated that participants suspended all non vitamin supplements two weeks prior to trial start and there were no side effects reported (so I suspect nobody had ringing in their ears even considering much higher doses used in the trial). 

    I am taking 600mg NAC  and 1gm Glycine in the morning and at lunch equal to a total of 1200mg NAC and 2gm Glycine per day. For my father double the dose above.

    Does any have any experience with berberine and what GlyNAC dose would do the same job of (lets say) 500mg Berberine for keeping blood sugar and insulin under control ?

    My first impressions are that my cognition has VASTLY improved from the day one taking the above stated dosages. It was a little bit like "turning on the lights". I am also feeling more energetic right up to the evening, less tired after lunch and much more focused at work.

    The results in the clinical trial, for a multitude of metabolic parameters, are of such great magnitude that other famous anti-aging supplements seem to me more like marketing hype at this point. 

    Does any body have real life experience with sleep quality with GlyNAC ? I am used to taking 3gr Melatonin, Ashwaganda and Magnesium threonate at night but I am not sure if this effects the ringing I am hearing in my ears the next day. What do YOU do for a good nights sleep when taking GlyNAC ? Maybe add Glycine by itself could be a solution. I will try this tonight...

    Do we know if any trial participants were taking blood pressure meds ?

    Any real life experience with GlyNAC supplementation would be greatly appreciated ! 

    Thanks in advance from Martino !   

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      • Brian Valerie
      • Semi-Retired Health Education Teacher
      • Brian_Valerie
      • 11 mths ago
      • Reported - view

      martino lorenzon I take 2 g each of NAC and glycine at bedtime and another 1 g of NAC and 1.5 g of glycine when I get up to use the restroom about 4 or 5 hours later.  I believe that I may have had a very slight improvement in sleep quality since adding this to my previous (and current) 3 mg of 6 hour extended time release melatonin and 4.5 g of ashwagandha at bedtime.  Hope that helps! 

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  • Hi Brian thanks for your answer. I gave up melatonin and magnesium threonate for myself and my father due to interactions with GlyNAC. I am pretty convinced of the negative  interactions although have no proof. Magnesium threonate is a special patented formulation that passes the blood brain barrier...I wonder if magnesium was mean to be in the brain in the first place if it doesn't naturally get to the brain !!.  We also gave up ashwaganda as a precautionary measure...not sure about that... maybe its good! 

    As for rest my 85yr old father seams to be better off on GlyNAC (compared to the prior supplement stack that included ...well everything ...about 20 supplements per day) although I find he has occasional high blood pressure.  What is your experience with blood pressure and GlyNAC ?  Do you think it interacts with blood pressure meds ? 

    For me (59yrs old) , after a few weeks now,  I still have ringing in my ears probably due to some effect of my prior supplementation either melatonin, Magnesium threonate or something else... nothing too annoying ..I can still go about my daily tasks...and I am hoping this will wear out over time ...

    About sleep you are right GlyNac definitely promotes better sleep ....and getting to sleep seams no problem these days (initially it was a problem!)....we take two capsules of cherry extract  to assist..  it seams to work well enough and I can sleep the night right through like that..  

    Dosages: so in the end today I am taking 1 gr Glycine and 600mg NAC three times spread through the  day. My father is taking 3gr Glycine and 1800mg NAC morning with blood pressure meds and the same 3gr Glycine and 1800mg NAC at night plus 2 capsules of cherry extract.  

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    • Brian Valerie
    • Semi-Retired Health Education Teacher
    • Brian_Valerie
    • 11 mths ago
    • Reported - view

    Hi Martino, My taking glycine and NAC evidently hasn't raised my rather consistently low blood pressure (about 110/65).  I'm skeptical that either of them have the negative interactions that you suspect, since NAC is simply the N-acetyl derivative of the amino acid L-cysteine, and glycine is likewise an amino acid.  As you probably know, both are natural precursors in the formation of the antioxidant glutathione in the body. As I mentioned, I also take melatonin and ashwagandha and get plenty of dietary magnesium without any negative effects.  By the way, tart cherries do also contain melatonin as well tryptophan.  Good luck!

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  • Brian that's amazing blood pressure ...good for you !.

    For the benefit of others that maybe on blood pressure meds I found this piece in the exclusion criteria for the participants of one of the  GlyNac trials: 

    "Any medication (prescription and non-prescription drugs) within 14 days before test product intake with the exception of stable therapy with thyroid hormones, anti-hypertensive medication (except beta blockers) ..."

    I interpret this as meaning that candidates with on blood pressure meds were able to partecipate as long as the medication was not a beta blocker ..

    This is from a supplementary table "DATASHEET 1_A..."   linked in   "A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage "   

    https://www.frontiersin.org/articles/10.3389/fragi.2022.852569/full

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  • more....I stopped GLYNAC two weeks ago due to anhedonia (I was basically emotionally dead and not very happy at all) ...  My 85 year old father is also trying GLYNAC but I suspect he is also suffering from anhedonia (dose 2gr Glycine and 1.8gr NAC morning and in the evening). In the absence of information that could ameliorate we will also discontinue his GLYNAC (which is a bit of a pity considering it is such a promising intervention). Does anybody have any insights on how this condition (anhedonia) could be mitigated ?

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    • martino lorenzon The solution would be to take something like wellbutrin or low-dose selegiline which I believe should be considered anyway after the age of >35.

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      • Brian Valerie
      • Semi-Retired Health Education Teacher
      • Brian_Valerie
      • 9 mths ago
      • Reported - view

      martino lorenzon Anhedonia has not been a widely reported side effect of GlyNAC supplementation.  I think that we should consider some other confounding variable(s) as the possible cause(s).

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