Rapamycin Cost
Let me clear some things up for people considering rapamycin (generic sirolimus). I am taking it and so are my dogs!! (I have a very open-minded vet who trusts my judgement.)
Dr. Green, a very impressive individual, gave me my personal prescription for sirolimus. I have a very good PPO (Blue Cross/Blue Shield). I took it to CVS, the affiliated pharmacy, and got a great price of about $2.90/mg. (Remember, you are only going to take about 3-6 mg/week.) With a PPO you can probably do this also. CVS wants to meter it to you with a month's worth of doses at a time, but that's just how they do things. You still have access to the full quantity prescribed.
With the prescription from my vet for my dogs, I was forced to take to the open sea. Armed with only a prescription and no insurance, the picture is quite different, but you can still get a good price. Cutting to the chase, I ended up at Walmart. The prescription was for 90 mg - price $1440. But wait! after presenting a coupon downloaded from GoodRX (that's right, just anonymously downloaded and printed) - price $396!!!! As my vet remarked, that's a hell of a charge for not looking around first! ($4.40/mg is better than taking a risk buying online, in my opinion.) Costco is pretty close to that price. At CVS/RiteAid, etc., you will pay vastly more.
You can't touch the original drug rapamune (Pfizer) unless you are wealthy or go to Canada. The problem with the online pharmacies is that a lot of them are scams. Just because they have a website doesn't mean anything. At least check to see if they have a brick and mortar location. Example: At one point I was excited by the online infomercials and wanted to take NMN instead of NR; however, when I looked up the reputations of the suppliers only one was unsullied, and on further investigation their brick and mortar location turned out to be a residential dwelling!
FYI, more than one company makes sirolimus. From CVS the sirolimus was made by Greenstone, LLC, apparently a wholly owned subsidiary of Pfizer.
Hope that helps some people who are considering rapamycin but think it might be out of their reach. If you know a doctor, great, but if you don't a visit to Dr. Green is worth the trip, and I live in CA! (round trip less than $300) Do your homework first and you will learn a great deal.
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Profound Products doesn't sell directly to consumers. I tried several companies they list but so far haven't found one that carries Rapa-Pro. I don't have a prescription. Angie4life, whom did you get yours from and did they require a prescription?
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Patrick McHargue
They referred me to The Longevity Store, which accepts credit cards.
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Don It seems that they only carry books - at least that's all I see under 'All Products' I use 'AllDayChemist.Com' for rapamycin and metformin. Still looking for a supplier of dasatinib (sprycel) which I'll use for the dasatinib/quercetin senolytic protocol.
Any suggestions on how to secure dasatinib? The 'https://theantiaging.store/' has issues with payments, and the suppliers in India are a confused mess. TIA
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angie4life and others, LDN: only posting this info for general knowledge; I buy 50mg Naltima (naltrexone) from: https://www.alldaychemist.com for about $1.20 per 50mg pill. I titrate down (dilute) with 1/2 cup + 2T water making for 5mg per tablespoon. Naltrexone disolves in water well. I keep it in the fridge. I moved to taking 5mg +/- in my morning vitamin smoothie to avoid the vivid dreams keeping me awake at night. I googled when to take LDN and day time is ok per my googling anyway. I pay allday as I did for the Indian and Chinese sources of Rapa via bank wire. I'm used to wiring funds and I have a bank that makes wiring very very easy (tiaabank.com) in 4 days or so they acknowledg recept of funds and have always shipped. Destination here in the US, customs has never kept my packages. I bought from the same Hunan China lab for rapa/dasi. I also bought from the same as others Indian Siromax (??) 1mg rapa. Next order I'll buy more chinese rapa and titrate as per helps here since I;m comfortable with home chemistry proceedures. Pure rapa powder is easier to work with if you are also home-making topical's vs crushing dilute 1mg pills...
I've taken LDN for anti aging, anti cancer for 10+ yrs and can't say any improvements. I take a mountain of sups per day that I'm certain much of it is making "expensive pee".... ;( Now adding most of the haufman protocol, spermidine, rapa +senolitics. The last is only a drop in my bucket. But I'm healthy in Paul's league, can physically work hard on my projects, rarely get sick etc etc. I took both age tests, saliva and the better blood test. My age score is NOT as good as Pauls,,,, I'm hoping that a year on rapa-dasin-senolitics will improve my dna age. Pauls my example to get to. :) :)
As I posted to another mountain of morning pills taker; I use a "tribest personal grinder" with 1/2 container water and drink it down in the early AM,,,, before my mind can mount a reason why not to drink such a nasty mix. LOL With all the berberine, ALA, quercetine, curcumins that stuff is a very strong yellow/orange dye. I have to be very careful to not drip on clothing or kitchen towels. I have no idea how a stomach can deal with those compounds!
I've questioned off and on the topic of; what nutricals/vitamins should not be combined, taken at the same time. But I've found little especially re the mix I take. I do separate out my 5 consecutive days per month I take the senolitic mix for a noon time away from food. I'm on an intermitant fasting diet later in the day first food.
Everyone here is the best! Very helping. Thanks to all. Happy and healthy 2021!
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Rudi Hoffman is this website IAS that you are referring to?
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Dennis , where do you get the NAD patches?
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See https://forum.rescueelders.org/t/x12myt/nad-patches for starters, David Michel provided some good info and he is ahead of me! He got nasal spray also but he may have paid a $350 consultation fee but that is just a guess.
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My dog, Bailey, and I have been taking Rapamycin now for going on 9 weeks. I under-dose Bailey, who is 110 pounds. He receives 1 mg every 3rd day of the week. He is 6 years old. His appetite has improved, and his mood is now downright joyful. He jumps and plays just like a puppy now. I hope to keep him on Rapamycin, perhaps with several breaks during the year. For myself, I take 1 mg with grapefruit juice once-a-week. I am 53 years of age, and I weigh 100 pounds. I was born with a birth defect that renders my left leg joints stiff and painful in the mornings. It works itself better as the day goes on. However, I should note here that around my 7th week on Rapamycin this morning joint stiffness and pain has completely disappeared. Seriously...no joke...this is a problem that I've had forever. I am a rapamycin believer. :) <3
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Bailey's Girl Wow!
Bailey's Girl said:
I was born with a birth defect that renders my left leg joints stiff and painful in the mornings. It works itself better as the day goes on. However, I should note here that around my 7th week on Rapamycin this morning joint stiffness and pain has completely disappeared.Wow! That is a great result ! I am a rapamycin believer, too, based on what I have learned from Dr. Alan Green and Mikhail Blogosklony and Dr. Matt Kaeberlein... and now from you.
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I found an app that reduces rapamycin cost with drug specific coupons to about 23% of public price. I have used it on two prescriptions. search for 'goodrx' and type in the rapamycin or sirolimus to see which pharmacies in your area are discounted
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See top... GoodRX reduced the price from $1440 to $396 for 90 mg at Walmart, not quite as good as your 23% but pretty great. It depends entirely where you take the coupon. Wahlgreens and CVS still wanted to overcharge, and they also limited the amount, regardless of what the coupon said. Costco is good. Don't assume your insurance won't cover.
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I am an 82 yr old who happened onto Rapamycin research from a psychology CEU class. I was doing CR, not overweight (5'3" 117#), taking Valsartan for HBP otherwise in good health (only arthritic stiffness). I have done supplements forever with who knows what results. In another CEU class I learned about benefits of modafinil (increased energy, motivation, concentration)which I take regularly (100mg daily). Other than those only bioidentical HR. The rapamycin research data persuaded me to give it a trial run. I purchased via dropmed and began in August with first 2mg then 3mg, weekly to test for side effects. I had mouth ulcers the first week; since then no noticeable side effects. Beginning in Sept I have taken 4mg every Fri morning. I also tried Metformin but couldn't tolerate the GI effects. As per Green's recommendation I began MittQ 100mg daily which may produce similar effects to Metformin? My observations so far (approx. 3 months): increased energy, greater flexibility and strength, improved gait (less wobbly). My activity level has significantly increased; for example, this morning I raked and bagged leaves; hauled logs in the house; swept out the garage--spending 2-3 hours actively moving in 40degree weather. In the recent past I could not have done this (too weak, too stiff) + wouldn't have had the energy or motivation to do it. The effect might be placebo; time will probably tell. I intend to continue on the present schedule. I will have lab work early January which I will report on. My cholest has always been low with HDL > LDL; all values except thyroid in range (I also supplement thyroid .075). I don't have any medical input at present.
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Janice I saw Dr. Green over 2 years ago. One of his first patients. At 82 yo., the ideal dose is probably 5 mg. weekly. Women require less than Men in that they are more sensitive to MTor inhibition than men. I take 6 mg. for 2 years, at 72 yo. No side effects. Also, Bicon is the largest manufacture in India, very good reputation, this is the brand Sirolimus that dropmedmd usually uses. Dr. Attia also recommends 4-7 mg., weekly for men
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Van You wrote "...5 mgs. weekly.... Women require less than men in that they are more sensitive to MTor inhibition than men."
I wonder who told you this, and how did that person measure mTor inhibition in men and in women in order to know that it is greater in men than in women?
I assume that since you went to see Dr. Green, he told you this.
With all due respect to Dr. Green, I am afraid that doctors often say things that they don't know is true, but they say it anyways, and they say it as if it is a fact. Then we accept it as true because a "doctor" said it, and then we repeat it, and it becomes a part of the "common wisdom."
But I have never seen or read anywhere that mTor inhibition has been measured in men or in women. So until I know that it can be measured, I will leave it in the bag of things that doctors say, but they are just guessing. I trust that MTor is being inhibited with rapamycin... but I have never read anywhere that it can be measured.
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Janice Sorry to go off topic but a quick question - how do you get modanifil, prescription?
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Ellis Toussier If I’m recalling correctly, I remember an animal study which showed amplification of Rapa in female mice over male mice. I will see if I can locate the research and repost here. From my somewhat limited experience with Dr. Green, he is very much a data driven MD and doesn’t recommend something without some research to point to.
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Ellis Toussier As a follow-up to my previous post, here is some additional info on female vs male Rapa impacts (in mice).
“Because recent studies showed that rapamycin increases longevity in a dose dependent manner and at every dose tested the effect remains larger in females than in males, we hypothesized that rapamycin should have a stronger effect on gene expression in females, and this effect could be dose dependent.”
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Ellis Toussier The comments on gender difference come from rat studies I have read. Can't find it now but it was cited by Blogoskolony (spell)
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Patient 139 Yes, I read them. Thank you for showing this to me.
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I am looking to obtain 1 mg tablets or capsules of rapamycin/sirolimus to be given to a small, 15 lb. dog.
If anyone has a quantity of 1 mg tabs they might want to provide (with appropriate compensation of course), please respond.
Am also interested in a joint buy, perhaps with dropshipmd or equivalent.
The antiaging.clinic option would be great if they offered 1 mg. The 5 mg size is too large to divide accurately. Thank you.
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I'm about out of my 5 mg tabs and pretty sure I used up all my 1 mg tabs I got from India so I guess I could try a joint buy to refill if no script is required. I could use ~6 mos. worth which would be about 125 mg. Five mg. tabs are easier for me to use since that's my normal weekly dose (~25-30 tabs).
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Dennis,
Thanks for considering my request. It sounds like you would be better off with the 5 mg tabs.
Unfortunately my small dog would likely require only around .5-.7 mg per dose and there is no way I could accurately divide a 5 mg tab into that small a part.
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Ozone8
FYI, I am getting quoted on 1mg tabs from India at $1.7 for an order qty of 500
pm me for details
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BobM My typical cost for sirolimus 1 mg tablets is $1 to $1.15. I've tried many suppliers that I find on Indiamart.com and all have delivered the product within 3 weeks or 4 weeks. You can use the https://www.scamadviser.com website to check the reseller reputation before you buy.
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Thanks, Bob. Tried to send you a pm, hope it went through.
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