Rapamycin Cost
Let me clear some things up for people considering rapamycin (generic sirolimus). I am taking it and so are my dogs!! (I have a very open-minded vet who trusts my judgement.)
Dr. Green, a very impressive individual, gave me my personal prescription for sirolimus. I have a very good PPO (Blue Cross/Blue Shield). I took it to CVS, the affiliated pharmacy, and got a great price of about $2.90/mg. (Remember, you are only going to take about 3-6 mg/week.) With a PPO you can probably do this also. CVS wants to meter it to you with a month's worth of doses at a time, but that's just how they do things. You still have access to the full quantity prescribed.
With the prescription from my vet for my dogs, I was forced to take to the open sea. Armed with only a prescription and no insurance, the picture is quite different, but you can still get a good price. Cutting to the chase, I ended up at Walmart. The prescription was for 90 mg - price $1440. But wait! after presenting a coupon downloaded from GoodRX (that's right, just anonymously downloaded and printed) - price $396!!!! As my vet remarked, that's a hell of a charge for not looking around first! ($4.40/mg is better than taking a risk buying online, in my opinion.) Costco is pretty close to that price. At CVS/RiteAid, etc., you will pay vastly more.
You can't touch the original drug rapamune (Pfizer) unless you are wealthy or go to Canada. The problem with the online pharmacies is that a lot of them are scams. Just because they have a website doesn't mean anything. At least check to see if they have a brick and mortar location. Example: At one point I was excited by the online infomercials and wanted to take NMN instead of NR; however, when I looked up the reputations of the suppliers only one was unsullied, and on further investigation their brick and mortar location turned out to be a residential dwelling!
FYI, more than one company makes sirolimus. From CVS the sirolimus was made by Greenstone, LLC, apparently a wholly owned subsidiary of Pfizer.
Hope that helps some people who are considering rapamycin but think it might be out of their reach. If you know a doctor, great, but if you don't a visit to Dr. Green is worth the trip, and I live in CA! (round trip less than $300) Do your homework first and you will learn a great deal.
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I am looking to obtain 1 mg tablets or capsules of rapamycin/sirolimus to be given to a small, 15 lb. dog.
If anyone has a quantity of 1 mg tabs they might want to provide (with appropriate compensation of course), please respond.
Am also interested in a joint buy, perhaps with dropshipmd or equivalent.
The antiaging.clinic option would be great if they offered 1 mg. The 5 mg size is too large to divide accurately. Thank you.
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I'm about out of my 5 mg tabs and pretty sure I used up all my 1 mg tabs I got from India so I guess I could try a joint buy to refill if no script is required. I could use ~6 mos. worth which would be about 125 mg. Five mg. tabs are easier for me to use since that's my normal weekly dose (~25-30 tabs).
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Well, I found a new "solution" to my rapamycin problem. After the AntiAging store "placebo debacle" (I never did get that refund), I thought I'd try again.
China.
I went to Alibaba, Dozens of "stores" sell rapamycin. I picked one that took a Mastercard. I ordered a 1 gram sample and waited. They sent 2.26 grams in error (usually they sell by the kilo so obviously were not concerned about a trivial weight difference) of what was claimed to be 99% medicinal grade rapamycin. The package was routed through the US and was opened and the sample split... There was a big DEA tape on the package... but I suspect they were looking for narcotics and found none.
It cost $100 US plus $50 shipping. I bought a jewelers scale, 2 lbs of lactose, then like "Breaking Bad", cut my 2.26 grams with the lactose. I calculated that 407 grams of my now diluted powder would contain a single gram of rapamycin. This is ~1/8th tsp of powder. I had been on it for 2 weeks, and got my trough level back today, 2.0. This is identical to level when taking the 1 gram of "Rapamune" at $10 per pill.
So, 150 for the rapamycin, $20 for the lactose, $30 for the scale. $200 US all in. I have 2260 doses of rapamycin. This would cost me $22,260.00 Canadian!
In my view, worth the bother. I would NOT do this without testing the drug, or blood levels, but is an option for those who can do some simple algebra and have a table-top mixer to compound the powder.
My kilo of resvratrol and a year of NMN is coming from the same supplier.
I hope this helps.
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Hi Bob. The test is a serum Sirolimus (Rapamycin) level. As most know, rapamycin is used in daily large doses to prevent rejection in renal transplant patients. I am assessing trough levels (before my daily 1 mg dose). For renal transplant patients the target trough level is between 5-15 ng/ml... with side-effects increasing along with this level. I suspect that any medical lab could run the test at a cost. There is no cost in Ontario as long as it's ordered by a physician. Of course I don't want that degree on immune suppression (as I am taking it to treat an autoimmune disorder).
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Just an update. I received a full refund from the AAS yesterday. They seemed unable to wire $ to Canada, but worked hard on a solution. I received a registered letter... with a cash refund in the mail. Above and beyond. I am pleased that I was part of the process that led to them identifying problems with their Rapa-pro product, but they dealt with it appropriately.
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I have been on hGH therapy with metformin, DHEA, and low dose statins for over 10 years. I'm now 80, exercise, and am in good health other than BPH. I was alarmed by Blagosklonny's and Dr Green's adamant opposition to hGH. Dr Fahy's thymus regeneration study leads me to believe that the years of growth hormone may have been useful after all, but now I dont know whether to continue. I plan to begin rapamycin therapy soon and would really appreciate the thoughts of the scientists on this forum whether some form of alternating between rapamycin and hGH makes any sense.
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Just starting my canine on rapamycin. He has periodontal disease so on a whim I checked if rapa had any affect. Unbelievably it is the only drug to ever show improvement and regrowth of bone in rodent age related periodontal disease. Is there an age related malady that this drug does not effect?
Rapamycin rejuvenates oral health in aging mice
Jonathan Y. An, Kristopher A. Kerns, Andrew Ouellette, Laura Robinson, Doug Morris, Catherine Kaczorowski, So-Il Park, Title Mekvanich, Alex Kang, Jeffrey S. McLean, Timothy C. Cox, View ORCID ProfileMatt Kaeberlein
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Hey Tom,
Not sure about the correct dose, but I've been giving my 11.9 yr old Chow Chow pup 2 mg of Sirolimus once a week for about 7-8 months. Not even sure about her weight, but I think about 55 lbs. She's done fine on it, and I'm wondering if I should up the dose a titch , as I can't figure out a way to get her to take it with grapefruit juice 😁. I take 3 mg once a week as well , and also have had zero side effects .
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Have been taking 6 mg Rapa weekly for 3 years, was Dr. Greens 2nd. patient 3 years ago. Am a 73 yo healthy male. I was motivated by Steve Roedde and I ordered and received 1.5 grams(1500 mg) of Pharma grade 99% Rapamycin powder from China, I paid $190 including $40 for shipping. No problem with Customs. (I live in Spain) Also, received 1 kg. Pharma grade Lactose powder which I will use to cut my Rapa. My intention is to mix the Rapa with 1/2 kg., 500 gm (500,000 mg.) of Lactose. Will hand mix per the protcol set forth on Pharma video for mixing powders. I will be using a SS spoon, instead of a Mortar and Pestal. Start with 1.5 grams rapa and add 1.5 grams of latose, mix very well, add 3.0 grams of latose to mixture and mix well, (doubling the mixture in bowl each cycle) repeating until all 500 grams has been mixed with the rapa. Time consuming, but the correct way to do it. Each 333.333 mg. (3.333 g) will contain 1 mg. Rapa. 500,000/1500.
I have not had the Rapa checked by the lab, but I have my lab results from 3 years back, and will be interesting to compare. I tried to pick a Pharma company that was legimate, to the best of my knowledge. Have included 4 pics. 3 of Rapa Assay, and 1 of Latose Powder. Any suggestions or help is appreciated.
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Does anyone know of a vet in NC, or anywhere else for that matter, that will prescribe Rapa for my Dog? He is in good health, but is starting to experience age-related issues with his legs. It breaks my heart to see him having problems. He is everything to me and I want to do everything/anything I can to help him. I have Dogs my whole life, but this little guy is so deep in my heart and I really want to help him. Can anyone please help me? I really need to find either a vet to prescribe, or a reliable source to purchase Rapa for him.
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I tried to find the main rapamycin thread here. A few that where just place holders for links to other groups. Please redirect me if this is not the main thread.
Another area /maybe this thread mentions increasing the aborbsion of rapa by ?? 25x via white grapefruit juice pre / post rapa dose.
Has anyone added this tactic to reduce the rapa total cost/consumption?
I agree if you buy from China at $60/gram why bother with grapefruit juice and affecting other things too. Even from India at $1/1mg for $5/week it may be a why bother. But still its a useful discussion that we may want to do this as a std protocol, no? tnx
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I just wanted to thank those that offered their experiences for acquiring Rapamycin via Alibaba... I was able to receive the 1 gram "sample" from the link provided iN this thread, and the shipment arrived 14 days later... The sample provided was 1,114 mg and I was able to cut the sample using lactose and the recommended method of geometric mixing... a shooter's reloading scale, stainless mixing bowl, and silicone whisker did the trick, probably spent a good hour mixing in all the additions... Took my first 5 mg dose and there is something very positive going on the next day with sleep, energy, mental focus, and well being. I am 55, excellent nutrition, supplementation, exercise and no health issues. Have been taking metformin for the last year, and will continue. I plan to increase the dose 1 mg per week until mouth ulceration is experienced, and will back off of that level, this to determine the optimal dose as explained in the literature in this thread. So thanks for the information, and just another data point about securing Rapa from a supplier on Alibaba.
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Thanks to the team and inputs here:
Another data point with the China Purchase of 10 grams for $660 includes the shipping cost. Obviously a couple people for a couple years each, a dog and for skin cream development. Male 60 and Female 53 in good health, no other meds, I'm athletic, she is not, looking for weight loss for her. My mom is 87, no meds, all her friends are dead, she still drives and works out with a trainer. She will also be on this for an old lady data point. On its way, should be here soon and will update if something happens.
Have 0,1mg scale ($300) range, simple cylindrical rock tumbler that I will use to perform extended mixing with red pill excipient off Amazon. I will also use gel caps Size 5 and a small hand unit to fill them with the 2,5-5 mg Rapa per dosage mixture I come up with. Have already looked, 1mg is infinitesimal amount of powder so will have to make a big batch to even fill size 5's.
I ran the stats on the small gunpowder scale and it is not doing so well, so I made sure to spend extra on the balance above to get something within the target measurements capability. Otherwise you have to make excessive batch sizes to be sure to be within 10%,,,,as I see some don't care about more than 10% dose difference, should be OK. The smaller the batch, the less storage issues I think?
For the cream, I will dissolve the Rapa powder in Vodka and add to a few mixes of coconut or other oils. May do DMSO or other solvents, those are mentioned in the patents. Even just heating may be enough to melt it, so we will see. But in a solvent it should be much easier to mix evenly into any oils. I always add a drop of oregano oil to make sure Im mixing clear contents up properly. Any other ideas on the cream? Crazy the number of patents with every conceivable delivery system or process for Rapa. Stents, Bone, heart, brain...everything pretty well covered, a lot of money to make, so I expect this to be the new vitamin next decade ;)
Thanks again to everyone for the honest discussions.
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Seemed like a good price, actually received two quotes from two suppliers and this one was the more expensive one, but shipping was cheaper so about the same total. Heck I spend more than $150 per month for two people on supplements now, another $30 per person and maybe I can drop the Resveratrol, PQQ, and a couple others and offset this, actually save money in the end. I'll have to consider the rest in the cost later.
Skin Cream
Yes, there is a paper on a study with 0.001 percent cream, other studies had much higher percentages.
https://link.springer.com/article/10.1007%2Fs11357-019-00113-y
"A notable aspect of this study is the use of such a low dose of rapamycin (10 μM, or 0.001%) for topical application. Topical treatment with higher concentrations (0.1–1%) has been employed for the treatment of tuberous sclerosis ..."
So we can make a cream/oil/lotion product at .01-.001 percent and get favorable results. Seems pretty inexpensive to me. Also, they did not see any leakage into the bloodstream. They show before and after results and sections of the skin that showed improved collagen production and retention. VERY promising indeed, the cellular structure that appeared chaotic, realigned and rebuilt itself...that's the kind of thing that reverses ageing!
These are the reasons I decided to go big on the order, I can easily make up lipbalm, creams, #5 capsules for a year supply with 300mg per person range. Try it out on three people at Low 50's, 60's and high 80's and get lots of data quickly. Get some blood work to keep track. Have a dozen other family members that will be interested if successful. looking for the Serolimus blood level test locally, might have to drive an hour to get this. This type of self doctoring seems the norm these days.
Lots of Doctors here, some good non-doc inputs too. My neighbors are docs, Surgical, ER and General...say their hands are pretty tied on new things and it is pretty hard to break out from the "system". So I understand where they are coming from. Good to have lots of inputs from various sources here...good team! I do not trust mouse results to translate well, but we don't have 30 years to wait for real science to catch up, we are all dead by then.