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Re: Intro to rapamycin @Jay Orman I started with 3mg in 4 ounces and used for about one year. Doubled concentration to 6mg in 4 ounces and used for about one year. Doubled again to 12mg in 4 ounces and have used for 2…
- Mark Thimineur
- Mark_Thimineur
- 1 yr ago
- 2
- Rapamycin Discussion
- Reported - view
Re: Anyone notice better dental health on rapamycin? @Sanford Finley "Rapamycin rejuvenates oral health in aging mice"10.7554/eLife.54318 This benefit has been quite obvious to me!!
- Mark Thimineur
- Mark_Thimineur
- 1 yr ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Dr Green new Rapamycin high dose @Michael Twice daily. Increased concentration to 6mg in 4 ounces DMSO/Aloe cream. The effects on face: I have not developed any fine wrinkles or furrowing - skin completely smooth - no crows feet,…
- Mark Thimineur
- Mark_Thimineur
- 1 yr ago
- 2
- Rapamycin Discussion
- Reported - view
Re: Dr Green new Rapamycin high dose @MAC. I believe Dr. Green's current weight is about 150 lbs which makes his biweekly dose about .15 mg/kg/wk which is not much different than my preferred dose of .18mg/kg/wk.…
- Mark Thimineur
- Mark_Thimineur
- 1 yr ago
- Rapamycin Discussion
- Reported - view
Re: Dr Green new Rapamycin high dose @MAC. I've limited sirolimus prescribing to family and friends and about 50 patients so my observations are limited. No observations of glucose elevation above normal.…
- Mark Thimineur
- Mark_Thimineur
- 1 yr ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Dr Green new Rapamycin high dose The biweekly dose is 30mg sirolimus without grapefruit juice. Every 6 week dosing of 90mg was 30mg sirolimus dosed with grapefruit juice. There are GI side effects dosing over 40-50mg at once so…
- Mark Thimineur
- Mark_Thimineur
- 1 yr ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Dr Green new Rapamycin high dose 30mg every two weeks for about one year. Experimented with 90mg every 6 weeks (30mg with fresh grapefruit) for about 6 months before, and weekly dose of 15mg prior to that.…
- Mark Thimineur
- Mark_Thimineur
- 1 yr ago
- 3
- Rapamycin Discussion
- Reported - view
Re: Intro to rapamycin @joseph mikhael I use the calcium salt (CaAKG)
- Mark Thimineur
- Mark_Thimineur
- 2 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Update on two dogs profiled in a 2016 CNN post about Rapamycin I use part of my own prescription for my pet. In general, I don't see many vets inclined to prescribe
- Mark Thimineur
- Mark_Thimineur
- 2 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Update on two dogs profiled in a 2016 CNN post about Rapamycin @shane The dog aging project phase 1 (10 week) trial was .05mg/kg and .1mg/kg three times weekly. Not sure the dosing in phase 2 of the study but assume it is similar.…
- Mark Thimineur
- Mark_Thimineur
- 2 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet? @JGC Average dietary lithium in humans is 0.5mg/day while some diets and some areas with higher lithium in the water supplies are double or triple that.…
- Mark Thimineur
- Mark_Thimineur
- 2 yrs ago
- 4
- Self-Experimentation
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet? Obtain powdered lithium chloride or lithium carbonate - costs about $5 for 30 grams from one of several internet sites such as homesciencetools.com. Mix in water to obtain some concentration like…
- Mark Thimineur
- Mark_Thimineur
- 2 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Intro to rapamycin @joseph mikhael Added 3000mg to 100cc water, put it in spray container, and apply - very easy
- Mark Thimineur
- Mark_Thimineur
- 2 yrs ago
- 2
- Rapamycin Discussion
- Reported - view
Re: Intro to rapamycin @Gokhan That concentration your are using is about 25 micromolar which is what I use on my face where it has the effect of slowing facial hair growth which is nice as it makes the daily shaves…
- Mark Thimineur
- Mark_Thimineur
- 2 yrs ago
- 2
- Rapamycin Discussion
- Reported - view
Re: Intro to rapamycin @Anna Marie Observations of 25 micromolar topical rapamycin on the skin of face and hand: fine wrinkles are eliminated slowly on face, more difficult to see this effect on hands.…
- Mark Thimineur
- Mark_Thimineur
- 2 yrs ago
- 5
- Rapamycin Discussion
- Reported - view
Re: Can any meaningful conclusions of efficacy/harm ever be drawn form individual experience/"self experimentation"? @MAC Six out of 15 family members from great grandparents through aunts/uncles lived past 100 yrs. Ancestry from Naples and central France. Strangely, Mom's side has very tall thin people ranging as…
- Mark Thimineur
- Mark_Thimineur
- 2 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Can any meaningful conclusions of efficacy/harm ever be drawn form individual experience/"self experimentation"? @MAC Just adding some more fodder. Rapamycin has well established effects on mood such as having both anti-depressive and anxiolytic effects. 10.1097/FBP.0000000000000334 .…
- Mark Thimineur
- Mark_Thimineur
- 2 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Can any meaningful conclusions of efficacy/harm ever be drawn form individual experience/"self experimentation"? @Steve Roedde Extrapolation's from laboratory animal studies are what is guiding rapamycin use and many of those studies are pure scientific method. I'm interestingly awaiting results from the dog…
- Mark Thimineur
- Mark_Thimineur
- 2 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost @Billy Smith I can't help you with vets in the Carolinas. I can suggest that you obtain it for yourself and use it for your dog - that seems somewhat easier. I can also suggest relative dosing.…
- Mark Thimineur
- Mark_Thimineur
- 2 yrs ago
- Self-Experimentation
- Reported - view
Re: Senolytics @garland Application frequency of topical sirolimus for skin aging is not established. Twice daily seems like it may allow a faster response than once daily, but who knows for sure.…
- Mark Thimineur
- Mark_Thimineur
- 2 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Senolytics @Fred Cloud Treatment of tuberous sclerosis skin lesions utilizes higher concentrations by 10-100 fold. Inhibition of mtor with higher concentrations is effective against angiofibromas because it…
- Mark Thimineur
- Mark_Thimineur
- 3 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Senolytics @John Mcgough Appears to be idiosyncratic reaction which I have observed in very few patients treating with rapamycin. My observations are that these type of reactions do not get better with time…
- Mark Thimineur
- Mark_Thimineur
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Preparations for self-treating COVID-19 @John Mcgough I've completed a trial of 0.08mg/kg up to 0.17mg/kg. Since I am 70kg this was 6mg on the low and 12mg on the high. In my individual case,…
- Mark Thimineur
- Mark_Thimineur
- 3 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Intro to rapamycin @Ed probably OK with other vehicles. I use DMSO base because the rapamycin is highly soluble in that but it likely OK in any sort of oily base
- Mark Thimineur
- Mark_Thimineur
- 3 yrs ago
- 2
- Rapamycin Discussion
- Reported - view
Re: Preparations for self-treating COVID-19 @Karl Everybody's wrong everybody's right Someone must be wrong when someone else is right Everybody's wrong everybody's right You tell me that I'm wrong Then you tell me that I'm right Can't stand…
- Mark Thimineur
- Mark_Thimineur
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view

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Mark Thimineur

Mark_Thimineur

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Joined: 13 Dec 2019

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