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Re: Intro to rapamycin @garland My daughter had small white bumps, known as syringomas, beneath her eyes. These bumps are a result of sweat gland duct enlargement and are quite common.…
- Mark Thimineur
- Mark_Thimineur
- 1 yr ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Intro to rapamycin @Jay Orman I started with 3mg in 4 ounces and used for about one year. Doubled concentration to 6mg in 4 ounces and used for about one year. Doubled again to 12mg in 4 ounces and have used for 2…
- Mark Thimineur
- Mark_Thimineur
- 2 yrs ago
- 2
- Rapamycin Discussion
- Reported - view
Re: Anyone notice better dental health on rapamycin? @Sanford Finley "Rapamycin rejuvenates oral health in aging mice"10.7554/eLife.54318 This benefit has been quite obvious to me!!
- Mark Thimineur
- Mark_Thimineur
- 2 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Dr Green new Rapamycin high dose @Michael Twice daily. Increased concentration to 6mg in 4 ounces DMSO/Aloe cream. The effects on face: I have not developed any fine wrinkles or furrowing - skin completely smooth - no crows feet,…
- Mark Thimineur
- Mark_Thimineur
- 2 yrs ago
- 2
- Rapamycin Discussion
- Reported - view
Re: Dr Green new Rapamycin high dose @MAC. I believe Dr. Green's current weight is about 150 lbs which makes his biweekly dose about .15 mg/kg/wk which is not much different than my preferred dose of .18mg/kg/wk.…
- Mark Thimineur
- Mark_Thimineur
- 2 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Dr Green new Rapamycin high dose @MAC. I've limited sirolimus prescribing to family and friends and about 50 patients so my observations are limited. No observations of glucose elevation above normal.…
- Mark Thimineur
- Mark_Thimineur
- 2 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Dr Green new Rapamycin high dose The biweekly dose is 30mg sirolimus without grapefruit juice. Every 6 week dosing of 90mg was 30mg sirolimus dosed with grapefruit juice. There are GI side effects dosing over 40-50mg at once so…
- Mark Thimineur
- Mark_Thimineur
- 2 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Dr Green new Rapamycin high dose 30mg every two weeks for about one year. Experimented with 90mg every 6 weeks (30mg with fresh grapefruit) for about 6 months before, and weekly dose of 15mg prior to that.…
- Mark Thimineur
- Mark_Thimineur
- 2 yrs ago
- 3
- Rapamycin Discussion
- Reported - view
Re: Intro to rapamycin @joseph mikhael I use the calcium salt (CaAKG)
- Mark Thimineur
- Mark_Thimineur
- 3 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Update on two dogs profiled in a 2016 CNN post about Rapamycin I use part of my own prescription for my pet. In general, I don't see many vets inclined to prescribe
- Mark Thimineur
- Mark_Thimineur
- 3 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Update on two dogs profiled in a 2016 CNN post about Rapamycin @shane The dog aging project phase 1 (10 week) trial was .05mg/kg and .1mg/kg three times weekly. Not sure the dosing in phase 2 of the study but assume it is similar.…
- Mark Thimineur
- Mark_Thimineur
- 3 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet? @JGC Average dietary lithium in humans is 0.5mg/day while some diets and some areas with higher lithium in the water supplies are double or triple that.…
- Mark Thimineur
- Mark_Thimineur
- 3 yrs ago
- 4
- Self-Experimentation
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet? Obtain powdered lithium chloride or lithium carbonate - costs about $5 for 30 grams from one of several internet sites such as homesciencetools.com. Mix in water to obtain some concentration like…
- Mark Thimineur
- Mark_Thimineur
- 3 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Intro to rapamycin @joseph mikhael Added 3000mg to 100cc water, put it in spray container, and apply - very easy
- Mark Thimineur
- Mark_Thimineur
- 3 yrs ago
- 2
- Rapamycin Discussion
- Reported - view
Re: Intro to rapamycin @Gokhan That concentration your are using is about 25 micromolar which is what I use on my face where it has the effect of slowing facial hair growth which is nice as it makes the daily shaves…
- Mark Thimineur
- Mark_Thimineur
- 3 yrs ago
- 2
- Rapamycin Discussion
- Reported - view
Re: Intro to rapamycin @Anna Marie Observations of 25 micromolar topical rapamycin on the skin of face and hand: fine wrinkles are eliminated slowly on face, more difficult to see this effect on hands.…
- Mark Thimineur
- Mark_Thimineur
- 3 yrs ago
- 5
- Rapamycin Discussion
- Reported - view
Re: Can any meaningful conclusions of efficacy/harm ever be drawn form individual experience/"self experimentation"? @MAC Six out of 15 family members from great grandparents through aunts/uncles lived past 100 yrs. Ancestry from Naples and central France. Strangely, Mom's side has very tall thin people ranging as…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Can any meaningful conclusions of efficacy/harm ever be drawn form individual experience/"self experimentation"? @MAC Just adding some more fodder. Rapamycin has well established effects on mood such as having both anti-depressive and anxiolytic effects. 10.1097/FBP.0000000000000334 .…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Can any meaningful conclusions of efficacy/harm ever be drawn form individual experience/"self experimentation"? @Steve Roedde Extrapolation's from laboratory animal studies are what is guiding rapamycin use and many of those studies are pure scientific method. I'm interestingly awaiting results from the dog…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost @Billy Smith I can't help you with vets in the Carolinas. I can suggest that you obtain it for yourself and use it for your dog - that seems somewhat easier. I can also suggest relative dosing.…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Senolytics @garland Application frequency of topical sirolimus for skin aging is not established. Twice daily seems like it may allow a faster response than once daily, but who knows for sure.…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Senolytics @Fred Cloud Treatment of tuberous sclerosis skin lesions utilizes higher concentrations by 10-100 fold. Inhibition of mtor with higher concentrations is effective against angiofibromas because it…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Senolytics @John Mcgough Appears to be idiosyncratic reaction which I have observed in very few patients treating with rapamycin. My observations are that these type of reactions do not get better with time…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Preparations for self-treating COVID-19 @John Mcgough I've completed a trial of 0.08mg/kg up to 0.17mg/kg. Since I am 70kg this was 6mg on the low and 12mg on the high. In my individual case,…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Intro to rapamycin @Ed probably OK with other vehicles. I use DMSO base because the rapamycin is highly soluble in that but it likely OK in any sort of oily base
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Rapamycin Discussion
- Reported - view

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Mark Thimineur

Mark_Thimineur

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Joined: 13 Dec 2019

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