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Re: Preparations for self-treating COVID-19 @Karl Everybody's wrong everybody's right Someone must be wrong when someone else is right Everybody's wrong everybody's right You tell me that I'm wrong Then you tell me that I'm right Can't stand…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Hyperbaric oxygen therapy I've been certified in hyperbaric medicine for 20 years and fill in from time to time at the hospital. It is primarily used for non-healing wounds. Multiplace chambers are also used for…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Rapamycin self-experimentation @uzoma iwuagwu 4 million basal cell carcinomas, 1 million squamous cell carcinomas, and 200 thousand melanomas are diagnosed yearly in the U.S. Over 90% of these are due to exposure to non-ionizing…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Rapamycin self-experimentation @Gokhan The papers you cite, and the general knowledge regarding immunosuppression in solid organ transplant recipients indicates very strongly that Cyclosporin (Sandimmune) is responsible with up…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 7
- Self-Experimentation
- Reported - view
Re: Senolytics @garland Topical takes time - by 4 months there will definitely be effects. Cant speak to sweats you experience - it does not go systemic but just sits on top of the cornified epithelium.…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Senolytics @garland Tailor Made lists it as "sirolimus" and I have recieved the 3mg capsules from a script. It seems they are currently backlogged - not sure if from pandemic or recent FDA inspection.…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Senolytics @garland The last page of that publication under the heading "Discussion" states the following "A notable aspect of this study is the use of such a low dose of rapamycin (10 μM, or 0.001%).…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Senolytics @garland Laser resurfacing and microneedling work because they create microscopic areas of injury in the epidermis which promotes collagen production and this technique is proven to improve the…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Senolytics @garland the 11 micromolar Tailor Made would be to strong for scalp. My 2 micromolar is made by adding 0.2 mg sirolimus to 100ml DMSO and using the pump spray attachment that comes with the bottle…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Senolytics @garland Noticed a error in my prior post on the topical formula. Funny how my mind came back to this one day later as if it was bothering me. The total amount of sirolimus reguired in all 5 of your…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Senolytics @garland The Tailor Made topical is .001% which is .01mg sirolimus per gram of the cream. I believe the Tailor Made topical is sold in 30 gram containers (of some sort).…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Which Dasatinib and Quercetin dosing regimen for longevity? @Randall James The founder and president of Telocyte LLC has written an opinion paper which supports Telemorase treatment for aging which is Telocyte's focus.…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Rapamycin self-experimentation @MAC There is now a singular exception to the longevity effect of rapamycin in all life forms, some of which were bred specifically to represent a condition or disease seen in humans.…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Senolytics @BobM low doses (.05-.08mg/kg) once weekly will enhance immune response but offers no protection against corona virus infection
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Sources for inexpensive prescription Rapamycin @Gytis Grinius tacrolimus is not an mtor inhibitor and has no utility as an anti aging pharmaceutical. Mechanism is similar to cyclosporin but more potent
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 4
- Rapamycin Discussion
- Reported - view
Re: Sources for inexpensive prescription Rapamycin @Gytis Grinius
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Senolytics @John Mcgough I've now set up a practice account with Tailor and trying to master their EMR. Created and sent first patient script for rapamycin 3mg capsules.…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Senolytics @John Mcgough Antibiotic eliminates the tick borne borrelia burgdorferi spirochete completely. If treated, there is no infection. Chronic lyme symptoms occur in rare patients.…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Senolytics @John Mcgough The combination of Graves dz, Addisons dz, diffuse pain, gut symptoms, frequent "sickness" may be related (polyglandular autoimmune syndrome(s) or other related disorders).…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost @angie4life Your dog weighs 25 kg. To up the dose give the 2mg twice weekly which is 0.08mg/kg. per dose. Canine metabolism is 30 hour half life compared to human metabolism of rapamycin at 60-70…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost @Tom Sage Dog weighs 7 kilos. Dose is 0.5mg twice weekly. Currently the medication is Biocon Sirolimus tablets 1mg cut in half.
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost Just starting my canine on rapamycin. He has periodontal disease so on a whim I checked if rapa had any affect. Unbelievably it is the only drug to ever show improvement and regrowth of bone in…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Senolytics @garland The answer to the other part of your question. Put the topical where it will do the most to enhance appearance. Usually that involves the face, front of the neck, back of your hands.…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Senolytics @garland They have .001% topical which is about 10 micromolar and it is available only with prescription. THe following link explains how I make the topical cream from tablets: https://forum.…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Senolytics @garland Interventional pain management specialist who has integrated several anti-aging treatments into the long term treatment plans for a growing number of my older chronic pain patients with…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view

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Mark Thimineur

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Joined: Fri Dec 13 17:31:37 UTC 2019

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