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Re: Rapamycin Cost @Larry to answer this with adequate explanation I’ll defer to study of grapefruit juice on drugs called “statins” which treat hypercholesterolemia. Like rapamycin the have low bioavailability (5%)…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 5
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost @Dennis The grapefruit juice option should be considered if a person is not concurrently taking drugs metabolized by intestinal P450 enzyme complex. The example of statins for cholesterol lowering…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 5
- Self-Experimentation
- Reported - view
Re: Intro to rapamycin @Sanford Finley The link is Cell Reports Volume 27, Issue 12, 18 June 2019, Pages 3413-3421.e3 A relevant paragraph below: (G) Rapamycin (1.6 μM) induces hair regeneration.…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 3
- Rapamycin Discussion
- Reported - view
Re: Intro to rapamycin @Sanford Finley Just wanted to comment on the topical cream. The concentration of 20mg in 4 ounces will be around 1.8 micro molar (approximate). The recent study of topical rapamycin which found…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 3
- Rapamycin Discussion
- Reported - view
Re: Intro to rapamycin @Sanford Finley
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Senolytics As a rapamycin and metformin user, I'm unsure if senolytics will offer additional advantage when combined with mtor inhibition. The main reason for doubt is that in vivo tissue studies of mice…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Rapamycin self-experimentation Karl As to the psychiatric effects: there are pretty profound effects on neurotransmitter concentrations and behavior observed in rodents Neuroscience. 2012 Oct 25; 223: 102–113.…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 6
- Self-Experimentation
- Reported - view
Re: Rapamycin self-experimentation This blog is a little long – sorry. Almost all self experimenters are motivated and generally in good health. Benefits of low dose intermittent rapamycin may not be obvious.…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 10
- Self-Experimentation
- Reported - view
Re: Hair regrowth Time honored proven treatments are Finasteride 1mg per day and topical minoxidil 2% or 5%. I'm 58 and have strong family history and was seeing male pattern baldness by my mid 30's.…
- Mark Thimineur
- Mark_Thimineur
- 5 yrs ago
- 4
- General Discussion
- Reported - view
Re: Cycling Rapamycin with NAD+ Precursors Being cautious at first, I spent 4 months on 3mg per week. My weight is about 70kg. On this low dose I noted some increased clarity, less anxiety, more stamina and energy about 4 weeks in.…
- Mark Thimineur
- Mark_Thimineur
- 5 yrs ago
- 4
- Rapamycin Discussion
- Reported - view
Re: Cycling Rapamycin with NAD+ Precursors Would like to share some insight into the combination of NR and rapamycin. I'm 58 yrs old and have been taking rapamycin for 9 months cycling doses between .1mg/kg/week to .…
- Mark Thimineur
- Mark_Thimineur
- 5 yrs ago
- 7
- Rapamycin Discussion
- Reported - view

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Mark Thimineur

Mark_Thimineur

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