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Re: Senolytics @garland Easy to make it. allowing 10% wastage it will be made by adding about 1.5mg to 4 ounces of whatever base you choose. Since the best solvent is DMSO I use a 70% DMSO/30% ALoe cream base and…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Senolytics @garland I've communicated with them directly and set up a physicians account for my practice. The price quoted to me was $3.50 for each 50mg capsule of dastinib.…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Finding a Dr to prescribe Metformin and Rapamycin @John Mcgough Compounding pharmacies are quite ubiquitious in the U.S. and provide needed services for human and veterinary medicine. Using drugs off-label for extremely valid medical reasons often…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- General Discussion
- Reported - view
Re: Finding a Dr to prescribe Metformin and Rapamycin @John Mcgough Tailor made compounding. The doctors office is required to send the script direct. https://tailormadecompounding.com/
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 3
- General Discussion
- Reported - view
Re: Finding a Dr to prescribe Metformin and Rapamycin Healthcare providers (MD, DO, APRN) have to abide by professional standards and law. This requires establishing a physician patient relationship, face to face visit(s),…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- General Discussion
- Reported - view
Re: Rapamycin Cost @Ellis Toussier The legal situation in the U.S. is real and any physician would put themselves in legal and professional jeopardy for prescribing this controlled substance without a legit medical…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost @Ellis Toussier Nothing personal - just quoting the science. 74 is not to old - you have 8 years to reach average male lifespan in Canada, 6 years for England, and 4 years for United States.
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost @Ellis Toussier For Baseball fans: 1998 Mark Mcguire total home runs - 70 1998 Sammy Sosa total home runs - 66 PED - Anabolic steroids (proven and admitted) 2001 Barry Bonds Home run total - 73 PED…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost @Dorian Gray This is my take for what it is worth. LC/MS/MS technology requires a specific method developed on each system to identify specific chemicals.…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Rapamycin self-experimentation @Sam Biller Predictable drug effects: minor dyslipidemia, borderline Hct. I see nothing to be concerned with - these minor blips are common among the patients on longevity rapa dosing.…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost @John Mcgough 3 weeks straight on each dose change. I am now cycling through 3 different doses (high, medium, low) each for 3 weeks.
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Intro to rapamycin @John Mcgough Mortor and pestle to reduce the pills to powder. Place the powder in a vessel for dissolving in DMSO. I use a test tube with a secure plug.…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 4
- Rapamycin Discussion
- Reported - view
Re: ResTorbio failure Endpoint of study not met. FDA studies require stict protocol. Their hypothesis that 16 weeks of drug around the time of flu season would make a difference for respiratory infection incidence was…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Rapamycin Cost @John Mcgough Link to prior post which is responsive in regards to my patients: https://forum.age-reversal.net/t/h4s991?r=80v57h Personal observations: Improvements: Mood, motivation, mental stamina,…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost @Karl For myself and anyone who is "self pay" the source is Biocon "Sirolimus" through online Canadian Pharmacy. Price $349 per 100 1mg tabs. For patients who go through insurance it is Pfizer…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 7
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost @Dennis Just following along on the back and forth and thought my two cents might be useful for some people. It is not specific to your last entry but simply a way to enter.…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 10
- Self-Experimentation
- Reported - view
Re: Senolytics @Paul Beauchemin More recently and to the point of senescence cell burden, studies of rodents treated with mtor inhibitor showed clearance of hepatic senescence which suggested a probable senolytic…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Senolytics Metformin is taken along with rapamycin to counteract some of the metabolic effects such as insulin resistance. I have no idea (nor does anyone) if the combo of these two drugs will be synergistic…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Intro to rapamycin @Dorian Gray Agree. All persons that I have responsibility for are using Rappamune (Pfizer) or Sirolimus (Biocon) which assures pharmaceutical grade. One can assume variable amounts of impurity from…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Intro to rapamycin @Sanford Finley Your new batch will be about 8-9 micromolar depending on wastage. I've used topical at 16-18 micromolar (2mg/4ounces) and repeated the experiment treating the back of my right hand…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 5
- Rapamycin Discussion
- Reported - view
Re: Intro to rapamycin @Sanford Finley Just wanted to let you know that my math was off. mixing 20mg of rapamycin in 4 ounces (assume U.S.) comes out to be a concentration of 185 micro molar.…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Rapamycin Discussion
- Reported - view
Re: High quality, affordable rapamycin (and other anti-aging meds) Rapamune (Pfizer) and generic sirolimus from Biocon (India) should be considered bioequivalent pharmaceutical grade medications. Patients have the same laboratory levels treated with either.…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- Announcements
- Reported - view
Re: Rapamycin Cost @Karl Agree. For the purposes of self experimenters, it would be helpful if expression of dose be done in the mg/kg such that the observations people are making could be better appreciated in terms…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost @Karl I saw a recent interview with Dr. Green state he was now taking 12mg per week and he also stated he had purposely lost 10 pounds making his body weight around 145 pounds or around 66kg so it…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost @BobM The only side effect of note has been mouth sores which I have seen in a very small % of patients taking .1mg/kg dose per week or less. I have seen two patients with an idiosyncratic reaction…
- Mark Thimineur
- Mark_Thimineur
- 4 yrs ago
- 3
- Self-Experimentation
- Reported - view

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Mark Thimineur

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Joined: Fri Dec 13 17:31:37 UTC 2019

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