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Fisetin to Clear Senescent Cells
Following studies with mice that showed significant senolytic clearance of senescent cells following large doses of the readily available flavenoid supplement Fisetin, my wife and I (ages 79 and 84) decided to try it. We have just completed two sets of massive Fisetin doses.
We had Life Extension blood-work done in October before the start, and we will have more again next week to observe any changes. The first set of Fisetin doses was on October 22-25 with 800 mg/day for three days followed by 600 mg on the fourth day, for a total of 4 g. I didn't notice much in the way of effects. Perhaps some reduction of small aches and pains and some increase in energy and mental acuity.
For the second set of doses done November 22-26, since we experienced no negative side effects in the first set we decided to increase the dosage a bit and to add 10 mg of BioPerine, a supplement that is reputed to magnify the effects and potency of flavenoids. For five days starting on Thanksgiving we took 500 mg of Fisetin and 10 mg of BioPerine twice per day, for a total of 5 g of Fisetin.
This time. I did experience one negative side effect. A few months ago, about 2 AM in the morning I awoke from a deep sleep and experienced a severe episode of vertigo. I turned over in bed, and the the whole room seemed to tilt. Suddenly, I didn't know which way was up. I staggered to the bathroom and vomited. The symptoms tapered off and disappeared in a few days, but it was a very distributing experience.
On the 2nd day of our 2nd Fisetin series, I experience a recurrence of that vertigo in the middle of the night, not as bad as my initial experience but still rather disturbing. I tolerated this mild vertigo and continued the treatment. My wife had no similar symptoms, and after my last dose I experienced no further vertigo symptoms.
On the positive side, following the second set of dosages I did feel very well, and very sharp and alert. This past weekend I ran my Shetland Sheepdog Taliesin in an AKC Canine Agility Trial in Mt. Vernon, WA, and we did very well, qualifying in 7 runs out of 15 and getting various colored placement ribbons. I was feeling quite sharp, and I even invented a new dog-handling technique that fixed an ongoing problem we were having.
Next week we will do the blood-work again, and I'll report any changes.
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Fisetin vs. D+Q
My wife and I have been starting our new senolytic doses on the 22nd of the month. In October and November, we took large doses of Fisetin, as reported above.
Today at 10 AM on empty stomachs, we took 200 mg of Dasatinib, 2,400 mg of Quercetin, and 10 mg of BioPerine. I'll report any side effects that we observe.
We plan to repeat this in a week, on the 29th. After that, we'll do bloodwork yet again and report any changes.
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Do you feel that the fiestin was more effective taken on an empty stomach? I've been on the life extension " version of the synolitic therapy, for over one month, and have noticed subtle yet profound changes. ( without the potential added benefit of taking on empty stomach) from now moving forward......
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D+Q+P Side Effects?
I do seem to notice some side effects from our D+Q+P (Dasatinib+Quercetin+Piperine) senolytic dose, taken about 24 hours ago. I had early morning stomach cramps and a mild headache, along with a mild feeling of unwellness (as if I was coming down with the flu). My temperature, however, is normal.
I take this as an indication that the D+Q+P treatment is dealing with some senescent cells in my lower digestive system and also has penetrated the blood-brain barrier. My wife has not experienced any similar symptoms.
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You might know about already, I did not: clinical trial to follow at Mayo. I might start with Fisetin after the first results appear, will see ...
https://clinicaltrials.gov/ct2/show/NCT03430037?cond=fisetin&cntry=US&rank=2