Fisetin to Clear Senescent Cells
Following studies with mice that showed significant senolytic clearance of senescent cells following large doses of the readily available flavenoid supplement Fisetin, my wife and I (ages 79 and 84) decided to try it. We have just completed two sets of massive Fisetin doses.
We had Life Extension blood-work done in October before the start, and we will have more again next week to observe any changes. The first set of Fisetin doses was on October 22-25 with 800 mg/day for three days followed by 600 mg on the fourth day, for a total of 4 g. I didn't notice much in the way of effects. Perhaps some reduction of small aches and pains and some increase in energy and mental acuity.
For the second set of doses done November 22-26, since we experienced no negative side effects in the first set we decided to increase the dosage a bit and to add 10 mg of BioPerine, a supplement that is reputed to magnify the effects and potency of flavenoids. For five days starting on Thanksgiving we took 500 mg of Fisetin and 10 mg of BioPerine twice per day, for a total of 5 g of Fisetin.
This time. I did experience one negative side effect. A few months ago, about 2 AM in the morning I awoke from a deep sleep and experienced a severe episode of vertigo. I turned over in bed, and the the whole room seemed to tilt. Suddenly, I didn't know which way was up. I staggered to the bathroom and vomited. The symptoms tapered off and disappeared in a few days, but it was a very distributing experience.
On the 2nd day of our 2nd Fisetin series, I experience a recurrence of that vertigo in the middle of the night, not as bad as my initial experience but still rather disturbing. I tolerated this mild vertigo and continued the treatment. My wife had no similar symptoms, and after my last dose I experienced no further vertigo symptoms.
On the positive side, following the second set of dosages I did feel very well, and very sharp and alert. This past weekend I ran my Shetland Sheepdog Taliesin in an AKC Canine Agility Trial in Mt. Vernon, WA, and we did very well, qualifying in 7 runs out of 15 and getting various colored placement ribbons. I was feeling quite sharp, and I even invented a new dog-handling technique that fixed an ongoing problem we were having.
Next week we will do the blood-work again, and I'll report any changes.
@saxxnviolins Juan Daw My purpose in mentioning dramamine was not to correct anything. The "old" formula contains dimenhydrinate and the "new" contains meclazine. Both are listed as having high anticholinergic activity. From RXFiles.ca: Diseases associated with an essential cholinergic deficit include Alzheimer’s dementia, Lewy body dementia & to some extent other dementias (not frontal). Anticholinergic drugs worsen the deficit & are therefore highly problematic (in older people- my add).
I have recently stopped taking Fisetin and Quercetin daily (500 mg each) due to severe side effects. My lips became painfully dry and cracked daily for about a month and this had never happened before in my life. This also made them susceptible to bacterial infection and my lips puffed up like a clown. It coincided with my taking Fisetin and Quercetin daily (as per Dr. Sinclair). After taking antibiotics to control the infection, my lips were still very dry cracked and painful. When I stopped taking fisetin and quercetin daily, my lips returned to normal. Has anyone else had a similar physiological response?
50 year old guy here.
Finally tried the fisetin hit and run regimen. Aimed for 30mg per kg dissolved in warm olive oil. Threw in 400mg of Q on top by taking a bio-available 250mg cap plus 2x the Life Extension Senolytic Activator. This for two days straight.
In preparation I had dropped anything like rapa, aspirin or glynac for 10 days that some here have stated might block results.
Honestly, I feel like I'm using my imagination to say that anything happened. My body temperature may have been half a degree C higher than normal. I might have felt slightly sweaty though it was hot weather anyway. I might have had a vague ache in my left hand finger joints. Now four days later I might have slightly better colour perception in my left eye.
See where I'm going? Really difficult to judge.
When I did a 500mg tolerance test last year, a cup of my black & green tea mix kicked off some sort of immune reaction for a while and the room swam. Much greater dose this time led to maybe something, but possibly nothing.
I will say that since my tolerance test last year I have dosed 100mg fisetin a couple of times a week. I have done a rapamycin protocol for around 2 months. I have done the odd alpha lipoic acid cleanout. Basically I'm not a clean slate when it comes to self experimentation.
However, all in all nothing really to report. I'm getting back on my rapa this afternoon.
My first reaction to Novusetin (Drs Best or Swanson) was wonderful. I felt absolutely fantastic for a few days, almost like a drug, and I suddenly had the ability to stay up all night without experiencing discomfort the following day. After not taking senolytics for months I have taken another set of doses. I take all 30 capsules in the bottle once/day with lots of Q and did this 3x in one week. No weakness or nausea. I am noticing a strength increase in the gym. I just added 10-20 lbs to almost everything I do. Also, I do 209 stairs two at a time and for the first time have been able to get through that without pausing. I have to say Novusetin is effective, theoretical absorbability notwithstanding. I'm 70.
This is the closest I can find. Dr. Kirkland is speaking about senolytics. Kirkland’s speech is mind blowing. Senescence spreads throughout your body? So senescent cells are like a disease. If you implant a mouse with senescent cells, it becomes frail and dies early. Wow. This changes my world view!
Professor James Kirkland’s, on senolytics, starts at 42:20.
Metformin - talk by Dr. Nir Barzilai starting at 1:33:09.