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Re: "Senolytic Activator" and Extended Fasting …
@albedo We don't have causality, without that all we have is different variables conflating with each other and can't say a-priori that it's senescence specifically.…
- skipping my funeral
- dantheman
- 6 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: "Senolytic Activator" and Extended Fasting …
@albedo Great thoughts. Unfortunately I don't think these tests will tell us specifically if senescent cells are being mitigated. The calculators are population referenced,…
- skipping my funeral
- dantheman
- 6 yrs ago
- 1
- Self-Experimentation
- Reported - view
Thymus aging mitigation strategies

OK time to start thinking about the thymus. First start with this blog post by Josh Mitteldorf (an aging theorist) which is a good introduction to the thymus and aging.…
- skipping my funeral
- dantheman
- updated 6 yrs ago
- 26replies
- 1584
- 5
- Thymus Regeneration
Re: Using chelation for cardiovascular health
@Jay Galambos said: I wasn't sure if this was an appropriate topic for a longevity discussion. B Yes it is! Thanks Jay, I'm sequentially building up a longevity program (have been for years),…
- skipping my funeral
- dantheman
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: "Senolytic Activator" and Extended Fasting …
@Iðunn Agree with your point here. Once you have the digestive tract interfering most (or many at least) compounds fail to have the same effect as they do when isolated.…
- skipping my funeral
- dantheman
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: MCC950
@Elizabeth Yurth said: Has anybody taken or know a reliable source for MCC950 This is a new one, looks like this comes from early work in the research labs. What's your motivation for trying it?
- skipping my funeral
- dantheman
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: Paul's Anti-Aging Efforts
Looks like a good lineup. A few others you should consider Testosterone cream - you may have but if not check your hormones. LE has lots of good information on target ranges.…
- skipping my funeral
- dantheman
- 6 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Evidence that the antibiotics azithromycin and roxithromycin are useful synolytics.
Good catch. Senolytics is a hot topic right now as it's been identified as a major component of aging, so I won't be surprised to see something be approved in the next decade.…
- skipping my funeral
- dantheman
- 6 yrs ago
- 1
- General Discussion
- Reported - view
Re: young.ai
@albedo one thing for sure is they are using young.ai to generate data to feed the networks to improve them. The time tracking especially will allow them to find how hyperparameters (e.…
- skipping my funeral
- dantheman
- 6 yrs ago
- Assessing Biological Age
- Reported - view
Re: young.ai
@albedo That's easy - use a VPN to alter your IP address. Private Internet Access is a excellent cheap one I use. Then connect to a server in the U.S. and voila,…
- skipping my funeral
- dantheman
- 6 yrs ago
- 1
- Assessing Biological Age
- Reported - view
Re: young.ai
@JGC @albedo This morning I'm going through and adding my data. They have another predictor here, for blood results they actually support Life Extension lab PDF files,…
- skipping my funeral
- dantheman
- 6 yrs ago
- 2
- Assessing Biological Age
- Reported - view
young.ai

The site https://young.ai from Insilico purports to tell you what you are doing (exercise, supplements, lifestyle etc) that helps, and what is aging you. Anybody try it?
- skipping my funeral
- dantheman
- 6 yrs ago
- 13replies
- 410
- Assessing Biological Age
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age
@albedo papers summarize and show results so unless they call out your question specifically you usually have to contact the authors directly. In this case the approach they took is standard and…
- skipping my funeral
- dantheman
- 6 yrs ago
- 1
- Assessing Biological Age
- Reported - view
Re: Adverse Reaction to Nad+ Patches
@BobM I just reminded myself of the IV approach. AFAIK it's 3 days not consecutively (like M-W-F). This may be for convenance (you have to sit at a clinic for hours) or because being just 3 is…
- skipping my funeral
- dantheman
- 6 yrs ago
- NAD+ Restoration
- Reported - view
Re: Adverse Reaction to Nad+ Patches
@BobM Frequency you mean? No more than 1/day, I did them on consecutive days. Don't see any reason to spread it out. Bill's recommendation is to do a box of patches,…
- skipping my funeral
- dantheman
- 6 yrs ago
- NAD+ Restoration
- Reported - view
Re: Rapamycin in humans
@are we there yet Don't forget that the gene CYP3A5 (rs776746) for those with the CC variant the half life of rapamycin is likely longer, ref https://www.pharmgkb.…
- skipping my funeral
- dantheman
- 6 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Rapamycin in humans
@albedo got that email too, thanks!
- skipping my funeral
- dantheman
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: Intro to rapamycin
@Iðunn Just relaying Bills message, and regardless he’s not saying Met replaces Rapa.
- skipping my funeral
- dantheman
- 6 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Intro to rapamycin
Update from the linked video; hot off the press "There is a change in the first step to substitute metformin and various forms of calorie reduction in lieu of rapamycin Current studies indicate a…
- skipping my funeral
- dantheman
- 6 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Intro to rapamycin
@AWaller OK Bill and team just sent out a email update where he says "Rapamycin update A drug called rapamycin has been shown to markedly increase lifespan in every animal model tested.…
- skipping my funeral
- dantheman
- 6 yrs ago
- 3
- Rapamycin Discussion
- Reported - view
Re: DHEA protocol?
FWIW I've started working my hormones recently. I had a free T of 5, age typical is more around 12, so armed with that I was able to start T therapy. Estradiol was low normal (30 I believe) and DHEA…
- skipping my funeral
- dantheman
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age
@albedo Thanks for the pointers, I'll try to find some time. I am focused on another project you folks might find interesting though, which is a DNN for doing regression analysis of biomarkers.…
- skipping my funeral
- dantheman
- 6 yrs ago
- 1
- Assessing Biological Age
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age
@albedo I'll try the earlier version, but assuming they used machine learning (a deep NN) for this, while larger (more input parameters) is generally better even more it's the population data.…
- skipping my funeral
- dantheman
- 6 yrs ago
- Assessing Biological Age
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age
@JGC Thanks for the Aging AI page. I'm 52, the spreadsheet puts me at 40 and Aging.ai 3.0 puts me at 28, FWIW.
- skipping my funeral
- dantheman
- 6 yrs ago
- 1
- Assessing Biological Age
- Reported - view
Re: Whole genome sequencing for $700-750?
@cacarr Thanks for the suggestion but I tried that, makes no difference. Glucose management overall is excellent as is A1C and I take back what I said above about 110 and a starchy dinner,…
- skipping my funeral
- dantheman
- 6 yrs ago
- General Discussion
- Reported - view

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