Evidence that the antibiotics azithromycin and roxithromycin are useful synolytics.
FTA,
Researchers here report on two new senolytic compounds identified in the existing library of approved drugs, based on screening work in cell cultures. It is worth bearing in mind that drug candidates that demonstrate good results in cell culture quite often fail to show promise when tested in animals, so it is wise to be patient as new senolytics work their way through the research and development pipeline.
This is good news, if true. I hope it becomes a candidate for more research.
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Good catch.
Senolytics is a hot topic right now as it's been identified as a major component of aging, so I won't be surprised to see something be approved in the next decade. Of course one of the best senolytic is a 3+ day water only fast, as Bill said recently in lecture.
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I have just ordered azithromycin. I will do a self experiment soon.
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"Phagocyte uptake and transport of azithromycin"
https://www.ncbi.nlm.nih.gov/pubmed/1662626
My English is not good enough to comprehend the paper, but it seems like tissues with inflammation get more azithromycin concentration.
For instance, if you have ear infection and take azithromycin, the ear gets more azithromycin concentration than the non-infected tissues. I could not find the sources in English, but I found some in Japanese that explains this behaviour of the drug.
If this is true, senescent cells might attract azithromycin through phagocyte, because senescent cells cause inflammation. In other words, if you have some kind of infection or strong inflammations, the senescent cells do not attract enough azithromycin concentration to kill the cells.
This could be the reason why those who had chlamydia treatment do not look young. :)
Do not take this argument serious, because I am not a scientist.
